JP2023502412A - 沈殿物からタンパク質を抽出する方法および不純物を沈殿させる方法 - Google Patents

沈殿物からタンパク質を抽出する方法および不純物を沈殿させる方法 Download PDF

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JP2023502412A
JP2023502412A JP2022529291A JP2022529291A JP2023502412A JP 2023502412 A JP2023502412 A JP 2023502412A JP 2022529291 A JP2022529291 A JP 2022529291A JP 2022529291 A JP2022529291 A JP 2022529291A JP 2023502412 A JP2023502412 A JP 2023502412A
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Japan
Prior art keywords
protein
interest
suspension
tank
permeate
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JP2022529291A
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Japanese (ja)
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JP2023502412A5 (enExample
Inventor
メンヤヴィ イブラヒム・エル
マルクス・ヴォン・ノルドハイム
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CSL Behring AG
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ZLB Bioplasma AG
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Priority claimed from AU2019904386A external-priority patent/AU2019904386A0/en
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Publication of JP2023502412A publication Critical patent/JP2023502412A/ja
Publication of JP2023502412A5 publication Critical patent/JP2023502412A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022529291A 2019-11-20 2020-11-20 沈殿物からタンパク質を抽出する方法および不純物を沈殿させる方法 Pending JP2023502412A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019904386 2019-11-20
AU2019904386A AU2019904386A0 (en) 2019-11-20 Novel process
PCT/EP2020/082806 WO2021099529A1 (en) 2019-11-20 2020-11-20 Method for extracting a protein from a precipitate and method for precipitating impurities

Publications (2)

Publication Number Publication Date
JP2023502412A true JP2023502412A (ja) 2023-01-24
JP2023502412A5 JP2023502412A5 (enExample) 2023-11-27

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JP2022529291A Pending JP2023502412A (ja) 2019-11-20 2020-11-20 沈殿物からタンパク質を抽出する方法および不純物を沈殿させる方法

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US (1) US12559520B2 (enExample)
EP (1) EP4061826A1 (enExample)
JP (1) JP2023502412A (enExample)
KR (1) KR20220101184A (enExample)
CN (1) CN114761417B (enExample)
AU (1) AU2020385637A1 (enExample)
CA (1) CA3157446A1 (enExample)
IL (1) IL293121A (enExample)
WO (1) WO2021099529A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4408572B1 (en) * 2021-09-28 2026-07-01 LPS Biosolutions A/S IMPROVED PROTEIN SORTING AND FILTRATION DEVICE
CN116120435A (zh) * 2023-02-15 2023-05-16 山西康宝生物制品股份有限公司 一种从血浆组分fiii沉淀中制备静注人免疫球蛋白的方法
US20240284944A1 (en) * 2023-02-28 2024-08-29 Xiong Wei Filtration methods and associated food products prepared using the same

Citations (6)

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JPH03271234A (ja) * 1990-03-20 1991-12-03 Nippon Sekijiyuujishiya 免疫グロブリンｇの製造方法
JP2003512594A (ja) * 1999-02-22 2003-04-02 コフ，ヘンリー 生体物質の精製
US20050053707A1 (en) * 2001-09-10 2005-03-10 Kopf Henry B Method and apparatus for separation of milk, colostrum, and whey
JP2013516429A (ja) * 2009-12-30 2013-05-13 ソレイ リミテッド ライアビリティ カンパニー ボーマン・バークインヒビタープロテインを大豆加工ストリームから回収する方法
CN105254754A (zh) * 2015-11-28 2016-01-20 上海洲跃生物科技有限公司 一种静注人免疫球蛋白（ph4）的制备方法
JP2017510452A (ja) * 2014-03-07 2017-04-13 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 生物学的生成物の分画のための装置及び方法

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BE629149A (enExample) 1962-03-03
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
NZ513242A (en) 1999-02-22 2003-10-31 Henry B Kopf Purification of biological substances
AU784808B2 (en) 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
RU2005129745A (ru) * 2003-02-24 2006-03-20 Джитиси Байотерапьютикс, Инк. (Us) Способы и устройство проточной фильтрации вдоль потока
AU2003238273A1 (en) * 2003-06-17 2005-02-04 Centocor, Inc. Method and apparatus for filtration of bioreactor recombinant proteins
CN101415482B (zh) * 2006-03-31 2015-04-15 金克克国际有限公司 用于化合物分离的切向流动过滤设备、系统和方法
NZ589297A (en) 2008-05-15 2011-12-22 Health L P W Process for producing milk fractions rich in secretory immunoglobulins
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
IL278584B2 (en) 2018-05-17 2025-08-01 Csl Behring Ag Method and system of protein extraction
CN108939922A (zh) 2018-08-07 2018-12-07 飞潮（无锡）过滤技术有限公司 一种旋转式陶瓷膜过滤分离工艺及装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03271234A (ja) * 1990-03-20 1991-12-03 Nippon Sekijiyuujishiya 免疫グロブリンｇの製造方法
JP2003512594A (ja) * 1999-02-22 2003-04-02 コフ，ヘンリー 生体物質の精製
US20050053707A1 (en) * 2001-09-10 2005-03-10 Kopf Henry B Method and apparatus for separation of milk, colostrum, and whey
JP2013516429A (ja) * 2009-12-30 2013-05-13 ソレイ リミテッド ライアビリティ カンパニー ボーマン・バークインヒビタープロテインを大豆加工ストリームから回収する方法
JP2017510452A (ja) * 2014-03-07 2017-04-13 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 生物学的生成物の分画のための装置及び方法
CN105254754A (zh) * 2015-11-28 2016-01-20 上海洲跃生物科技有限公司 一种静注人免疫球蛋白（ph4）的制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"「ナノ粒子の目詰まりを抑制！回転式セラミックフィルターの活用事例」", [ONLINE], INTERNET, vol. （2018.02版）, JPN6024043725, 2018, pages 8, ISSN: 0005656501 *
佐藤和夫、外２名: "「回転型セラミックフィルターによる清酒のクロスフローろ過」", 日本醸造協会誌（J. BREW. SOC. JAPAN）, vol. 93, no. 6, JPN6025031759, 1998, pages 475 - 480, ISSN: 0005656502 *

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Publication number Publication date
US20230002444A1 (en) 2023-01-05
IL293121A (en) 2022-07-01
CN114761417A (zh) 2022-07-15
KR20220101184A (ko) 2022-07-19
US12559520B2 (en) 2026-02-24
CA3157446A1 (en) 2021-05-27
EP4061826A1 (en) 2022-09-28
CN114761417B (zh) 2026-06-02
WO2021099529A1 (en) 2021-05-27
AU2020385637A1 (en) 2022-06-09

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