CN114761417B - 用于从沉淀物提取蛋白的方法和用于沉淀杂质的方法 - Google Patents

用于从沉淀物提取蛋白的方法和用于沉淀杂质的方法

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Publication number
CN114761417B
CN114761417B CN202080080983.8A CN202080080983A CN114761417B CN 114761417 B CN114761417 B CN 114761417B CN 202080080983 A CN202080080983 A CN 202080080983A CN 114761417 B CN114761417 B CN 114761417B
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CN
China
Prior art keywords
suspension
tank
permeate
retentate
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080080983.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN114761417A (zh
Inventor
易卜拉欣·埃尔门亚韦
马克斯·冯诺德海姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring AG
Original Assignee
CSL Behring AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2019904386A external-priority patent/AU2019904386A0/en
Application filed by CSL Behring AG filed Critical CSL Behring AG
Publication of CN114761417A publication Critical patent/CN114761417A/zh
Application granted granted Critical
Publication of CN114761417B publication Critical patent/CN114761417B/zh
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202080080983.8A 2019-11-20 2020-11-20 用于从沉淀物提取蛋白的方法和用于沉淀杂质的方法 Active CN114761417B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019904386 2019-11-20
AU2019904386A AU2019904386A0 (en) 2019-11-20 Novel process
PCT/EP2020/082806 WO2021099529A1 (en) 2019-11-20 2020-11-20 Method for extracting a protein from a precipitate and method for precipitating impurities

Publications (2)

Publication Number Publication Date
CN114761417A CN114761417A (zh) 2022-07-15
CN114761417B true CN114761417B (zh) 2026-06-02

Family

ID=73554418

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080080983.8A Active CN114761417B (zh) 2019-11-20 2020-11-20 用于从沉淀物提取蛋白的方法和用于沉淀杂质的方法

Country Status (9)

Country Link
US (1) US12559520B2 (enExample)
EP (1) EP4061826A1 (enExample)
JP (1) JP2023502412A (enExample)
KR (1) KR20220101184A (enExample)
CN (1) CN114761417B (enExample)
AU (1) AU2020385637A1 (enExample)
CA (1) CA3157446A1 (enExample)
IL (1) IL293121A (enExample)
WO (1) WO2021099529A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4408572B1 (en) * 2021-09-28 2026-07-01 LPS Biosolutions A/S IMPROVED PROTEIN SORTING AND FILTRATION DEVICE
CN116120435A (zh) * 2023-02-15 2023-05-16 山西康宝生物制品股份有限公司 一种从血浆组分fiii沉淀中制备静注人免疫球蛋白的方法
US20240284944A1 (en) * 2023-02-28 2024-08-29 Xiong Wei Filtration methods and associated food products prepared using the same

Citations (4)

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JPH03271234A (ja) * 1990-03-20 1991-12-03 Nippon Sekijiyuujishiya 免疫グロブリンｇの製造方法
EP2583744A1 (en) * 2006-03-31 2013-04-24 Genencor International, Inc. Permeate product of tangential flow filtration process
CN108939922A (zh) * 2018-08-07 2018-12-07 飞潮（无锡）过滤技术有限公司 一种旋转式陶瓷膜过滤分离工艺及装置
CN112074528A (zh) * 2018-05-17 2020-12-11 瑞士杰特贝林生物制品有限公司 用于蛋白提取的方法和系统

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BE629149A (enExample) 1962-03-03
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
NZ513242A (en) 1999-02-22 2003-10-31 Henry B Kopf Purification of biological substances
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
AU784808B2 (en) 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
RU2005129745A (ru) * 2003-02-24 2006-03-20 Джитиси Байотерапьютикс, Инк. (Us) Способы и устройство проточной фильтрации вдоль потока
AU2003238273A1 (en) * 2003-06-17 2005-02-04 Centocor, Inc. Method and apparatus for filtration of bioreactor recombinant proteins
NZ589297A (en) 2008-05-15 2011-12-22 Health L P W Process for producing milk fractions rich in secretory immunoglobulins
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
CN103988973A (zh) * 2009-12-30 2014-08-20 索莱有限责任公司 大豆乳清蛋白组合物及其回收方法
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
WO2015133972A1 (en) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
CN105254754A (zh) * 2015-11-28 2016-01-20 上海洲跃生物科技有限公司 一种静注人免疫球蛋白（ph4）的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03271234A (ja) * 1990-03-20 1991-12-03 Nippon Sekijiyuujishiya 免疫グロブリンｇの製造方法
EP2583744A1 (en) * 2006-03-31 2013-04-24 Genencor International, Inc. Permeate product of tangential flow filtration process
CN112074528A (zh) * 2018-05-17 2020-12-11 瑞士杰特贝林生物制品有限公司 用于蛋白提取的方法和系统
CN108939922A (zh) * 2018-08-07 2018-12-07 飞潮（无锡）过滤技术有限公司 一种旋转式陶瓷膜过滤分离工艺及装置

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
吴志韡等.静脉人免疫球蛋白辛酸分离工艺研究.世界临床医学.2015,第274页第1.2.2小节，第274页第1.2.2小节. *
静脉人免疫球蛋白辛酸分离工艺研究;吴志韡等;世界临床医学;20150831;第274页第1.2.2小节，第274页第1.2.2小节 *

Also Published As

Publication number Publication date
US20230002444A1 (en) 2023-01-05
JP2023502412A (ja) 2023-01-24
IL293121A (en) 2022-07-01
CN114761417A (zh) 2022-07-15
KR20220101184A (ko) 2022-07-19
US12559520B2 (en) 2026-02-24
CA3157446A1 (en) 2021-05-27
EP4061826A1 (en) 2022-09-28
WO2021099529A1 (en) 2021-05-27
AU2020385637A1 (en) 2022-06-09

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