CA3157446A1 - Method for extracting a protein from a precipitate and method for precipitating impurities - Google Patents

Method for extracting a protein from a precipitate and method for precipitating impurities Download PDF

Info

Publication number
CA3157446A1
CA3157446A1 CA3157446A CA3157446A CA3157446A1 CA 3157446 A1 CA3157446 A1 CA 3157446A1 CA 3157446 A CA3157446 A CA 3157446A CA 3157446 A CA3157446 A CA 3157446A CA 3157446 A1 CA3157446 A1 CA 3157446A1
Authority
CA
Canada
Prior art keywords
protein
interest
suspension
tank
permeate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3157446A
Other languages
English (en)
French (fr)
Inventor
Marcus VON NORDHEIM
Ibrahim EL MENYAWI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring AG
Original Assignee
CSL Behring AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2019904386A external-priority patent/AU2019904386A0/en
Application filed by CSL Behring AG filed Critical CSL Behring AG
Publication of CA3157446A1 publication Critical patent/CA3157446A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3157446A 2019-11-20 2020-11-20 Method for extracting a protein from a precipitate and method for precipitating impurities Pending CA3157446A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019904386 2019-11-20
AU2019904386A AU2019904386A0 (en) 2019-11-20 Novel process
PCT/EP2020/082806 WO2021099529A1 (en) 2019-11-20 2020-11-20 Method for extracting a protein from a precipitate and method for precipitating impurities

Publications (1)

Publication Number Publication Date
CA3157446A1 true CA3157446A1 (en) 2021-05-27

Family

ID=73554418

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3157446A Pending CA3157446A1 (en) 2019-11-20 2020-11-20 Method for extracting a protein from a precipitate and method for precipitating impurities

Country Status (9)

Country Link
US (1) US12559520B2 (enExample)
EP (1) EP4061826A1 (enExample)
JP (1) JP2023502412A (enExample)
KR (1) KR20220101184A (enExample)
CN (1) CN114761417B (enExample)
AU (1) AU2020385637A1 (enExample)
CA (1) CA3157446A1 (enExample)
IL (1) IL293121A (enExample)
WO (1) WO2021099529A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4408572B1 (en) * 2021-09-28 2026-07-01 LPS Biosolutions A/S IMPROVED PROTEIN SORTING AND FILTRATION DEVICE
CN116120435A (zh) * 2023-02-15 2023-05-16 山西康宝生物制品股份有限公司 一种从血浆组分fiii沉淀中制备静注人免疫球蛋白的方法
US20240284944A1 (en) * 2023-02-28 2024-08-29 Xiong Wei Filtration methods and associated food products prepared using the same

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629149A (enExample) 1962-03-03
JPH0778025B2 (ja) 1990-03-20 1995-08-23 日本赤十字社 免疫グロブリンｇの製造方法
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
NZ513242A (en) 1999-02-22 2003-10-31 Henry B Kopf Purification of biological substances
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
AU784808B2 (en) 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
RU2005129745A (ru) * 2003-02-24 2006-03-20 Джитиси Байотерапьютикс, Инк. (Us) Способы и устройство проточной фильтрации вдоль потока
AU2003238273A1 (en) * 2003-06-17 2005-02-04 Centocor, Inc. Method and apparatus for filtration of bioreactor recombinant proteins
CN101415482B (zh) * 2006-03-31 2015-04-15 金克克国际有限公司 用于化合物分离的切向流动过滤设备、系统和方法
NZ589297A (en) 2008-05-15 2011-12-22 Health L P W Process for producing milk fractions rich in secretory immunoglobulins
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
CN103988973A (zh) * 2009-12-30 2014-08-20 索莱有限责任公司 大豆乳清蛋白组合物及其回收方法
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
WO2015133972A1 (en) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
CN105254754A (zh) * 2015-11-28 2016-01-20 上海洲跃生物科技有限公司 一种静注人免疫球蛋白（ph4）的制备方法
IL278584B2 (en) 2018-05-17 2025-08-01 Csl Behring Ag Method and system of protein extraction
CN108939922A (zh) 2018-08-07 2018-12-07 飞潮（无锡）过滤技术有限公司 一种旋转式陶瓷膜过滤分离工艺及装置

Also Published As

Publication number Publication date
US20230002444A1 (en) 2023-01-05
JP2023502412A (ja) 2023-01-24
IL293121A (en) 2022-07-01
CN114761417A (zh) 2022-07-15
KR20220101184A (ko) 2022-07-19
US12559520B2 (en) 2026-02-24
EP4061826A1 (en) 2022-09-28
CN114761417B (zh) 2026-06-02
WO2021099529A1 (en) 2021-05-27
AU2020385637A1 (en) 2022-06-09

Similar Documents

Publication Publication Date Title
US20230055416A1 (en) Method and system of protein extraction
US12559520B2 (en) Method for extracting a protein from a precipitate and method for precipitating impurities
EP1601788A1 (en) Methods of tangential flow filtration and an apparatus therefore
JP7133925B2 (ja) ウイルス濾過
EP3362464A1 (en) Methods for extracting proteins from blood plasma
EP2748193B1 (en) Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
JPH07506487A (ja) 乳漿から高品質タンパク製品を得る方法
US20240336650A1 (en) Plasma fractionation by continuous extraction
US20180079779A1 (en) Method for the purification of a therapeutic recombinant protein from transgenic milk
WO2025229607A1 (en) Systems and methods for solid-liquid separation
KR20250004876A (ko) 한외여과를 통한 혈장으로부터 콘 풀 농축액을 제조하는 방법
HK1208872B (en) Purification of polypeptides using dual stage tangential-flow ultrafiltration
HK1199267B (en) Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition

Legal Events

Date Code Title Description
D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D11-D117 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION RECEIVED

Effective date: 20241119

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - VOLUNTARY AMENDMENT

Effective date: 20241119

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241119

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D118 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20241223

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20241223

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20241223

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241223

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250425

D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D11-D155 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALL REQUIREMENTS FOR EXAMINATION DETERMINED COMPLIANT

Effective date: 20250429

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260108

U13 Renewal or maintenance fee not paid

Free format text: ST27 STATUS EVENT CODE: N-2-6-U10-U13-U300 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO MAINTENANCE FEE NOTICE

Effective date: 20260520