JP2023166713A - Oral composition - Google Patents

Abstract

To provide oral compositions with excellent cooling effect and suppressed bitterness derived from di-long chain cationic surfactants.SOLUTION: An oral composition according to the present invention contains ingredient (A): menthol or a derivative thereof, ingredient (B): a di-long chain cationic surfactant, and ingredient (C): sugar alcohol and/or glycerin, the content of the component (A) being 0.01 to 1.5 mass%, and the content of the component (B) being 0.005 to 1.5 mass%. Preferably, the component (A) is l-menthol. Also preferably, the di-long chain cationic surfactant has 14 to 22 carbon atoms in one chain length.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to oral compositions.

Cationic surfactants have long been known in the cosmetics field to have the effect of improving the stability, cleansing properties, powder dispersibility, etc. of formulated formulations, and are used in emulsified cosmetics, etc. For example, Patent Document 1).

In addition, in recent years, it has been discovered that when a di-long-chain cationic surfactant is added to cosmetics in combination with a cooling agent such as menthol, the cooling effect can be improved. Oil-in-water emulsion cosmetics have been proposed in which a chain-type cationic surfactant is blended to improve the cooling effect and emulsion stability (for example, Patent Document 2).

Japanese Patent Application Publication No. 2007-246521 JP2013-82687A

By the way, in oral compositions, there is no formulation that combines a di-long chain cationic surfactant and a cooling agent, but it is expected that the combination will result in an oral composition with an excellent cooling effect. be done.
However, oral compositions that combine a di-long chain cationic surfactant and a refreshing agent have a high cooling effect, but the characteristic bitterness of the di-long chain cationic surfactant occurs, making it difficult to use as an oral composition. It was not usable.

Therefore, an object of the present invention is to provide an oral composition that has an excellent cooling effect and suppresses the bitter taste derived from di-long chain cationic surfactants.

The oral composition according to the present invention comprises (A) component: menthol or its derivative;
(B) Component: di-long chain cationic surfactant,
(C) Component: Contains sugar alcohol and/or glycerin,
The content of the component (A) is 0.01 to 1.5% by mass,
The content of the component (B) is 0.005 to 1.5% by mass.

According to the present invention, it is possible to provide an oral composition that has an excellent cooling effect and suppresses the bitter taste derived from di-long chain cationic surfactants.

Hereinafter, preferred embodiments of the oral composition of the present invention will be described in detail.
In addition, the oral composition in this specification includes dentifrices such as toothpaste, moisturized dentifrice, powdered dentifrice, liquid dentifrice, and liquid dentifrice, troches, tablets, creams, and ointments. , patches, mouth washes, chewing gum, etc. Among these, the oral composition of the present invention is preferably applied to a liquid dentifrice, a toothpaste, a moisturized dentifrice, or a mouthwash; More preferred.

The oral composition of the present invention contains (A) component: menthol or its derivative, (B) component: di-long chain cationic surfactant, and (C) component: sugar alcohol and/or glycerin. It is something.
By containing these components, it is possible to provide an oral composition that has an excellent cooling effect and suppresses the bitter taste derived from the di-long chain cationic surfactant.

<(A) component>
The oral composition of the present invention contains 0.01 to 1.5% by mass of menthol or a derivative thereof as component (A). By including such component (A), a refreshing feeling is expressed after use of the oral composition.
Examples of menthol include d-menthol, l-menthol, and dl-menthol, and among these, it is preferable to use l-menthol.
Examples of menthol derivatives include menthyl lactate, l-menthyl glyceryl ether, l-menthyl glucoside, l-menthyl hydroxybutyrate, menthoxypropanediol, menthoxyfuran, and the like.
In the oral composition of the present invention, the content of component (A) is 0.01 to 1.5% by mass, preferably 0.05 to 1.2% by mass, and preferably 0.1 to 1.2% by mass. More preferably, it is 1.0% by mass. If the content of component (A) is less than the lower limit, a sufficient refreshing feeling cannot be obtained. On the other hand, if the content of component (A) exceeds the above upper limit, a cooling sensation can be obtained, but the taste derived from component (A) will affect the taste of the oral composition, resulting in bitterness. It may be felt.

<(B) component>
The oral composition of the present invention contains 0.005 to 1.5% by mass of a di-long chain cationic surfactant as component (B). By including the di-long chain cationic surfactant, the refreshing feeling of the component (A) can be enhanced.
The di-long chain cationic surfactant preferably has 14 to 22 carbon atoms, more preferably 16 to 20 carbon atoms. Thereby, the sensitivity of the component (A) in the oral cavity can be increased, and the refreshing feeling can be made higher.
Examples of di-long chain cationic surfactants include dibehenyldimethylammonium, dicetostearyldimethylammonium, dimyristyldimethylammonium, dioctadecyldimethylammonium, distearyldimethylammonium, dicocoylethylhydroxyethylmonium, and didecyldimethylammonium. Dimethylammonium, dicocoyldimethylammonium, dicocoyldimethylammonium, dilauryldimethylammonium, dicetyldimethylammonium, dipalmityldimethylammonium, dioleyldimethylammonium, dipalmitoylethylhydroxyethylmonium, dicocoylhydroxyethylmethylmonium, distearyl Examples include ethylhydroxyethylmonium or salts thereof (halides (chloride, bromide, etc.) and methosulfate). Among these, it is preferable to use distearyldimethylammonium or a salt thereof, more preferably to use distearyldimethylammonium chloride or distearyldimethylammonium bromide, and even more preferably to use distearyldimethylammonium chloride. Thereby, the sensitivity of the component (A) in the oral cavity can be increased, and the refreshing feeling can be made higher.
In the oral composition of the present invention, the content of component (B) is 0.005 to 1.5% by mass, preferably 0.01 to 1.2% by mass, and preferably 0.1 to 1.2% by mass. More preferably, it is 1.0% by mass. If the content of component (A) is less than the lower limit, the effect of improving the refreshing feeling may not be sufficiently achieved. On the other hand, if the content of component (A) exceeds the upper limit, the taste derived from component (B) will affect the taste of the oral composition, resulting in a bitter taste.

<(C) component>
The oral composition of the present invention contains sugar alcohol and/or glycerin as component (C). By containing component (C), the bitterness of component (B) can be suppressed. Moreover, the dispersibility of component (A) in the oral cavity when using the oral composition can be improved, and the refreshing feeling can be improved.
Examples of sugar alcohols include threitol, erythritol, pentaerythritol, dipentaerythritol, tripentaerythritol, arabitol, ribitol, xylitol, sorbitol, mannitol, threitol, glitol, talitol, galactitol, allitol, althritol, dolcitol, iditol , inositol, maltitol, isomaltitol, lactitol, turanitol, etc., and one or more of these can be used in combination. Among these, it is preferable to use one selected from the group consisting of sorbitol, xylitol, erythritol, maltitol, and mannitol.

In the oral composition of the present invention, the content of component (C) is not particularly limited, but is preferably 1 to 50% by mass, more preferably 3 to 40% by mass, and 5 to 30% by mass. % is more preferable. Thereby, the bitterness of the component (B) can be suppressed more efficiently while suppressing the influence of the component (C) itself on the taste.

<Other ingredients>
The oral composition of the present invention may contain various components depending on its dosage form. For example, the oral composition of the present invention may contain abrasives, humectants (wetting agents other than glycerin and sugar alcohols), binders, foaming agents, sweeteners, preservatives, fragrance ingredients, medicinal ingredients, etc. be able to.
Examples of abrasives include silica-based abrasives such as silica gel, precipitated silica, igneous silica, hydrated silicic acid, anhydrous silicic acid, zeolite, aluminosilicate, and zirconosilicate, dibasic calcium phosphate dihydrate, and dibasic calcium phosphate. Calcium hydrogen phosphate for toothpaste such as anhydrate, calcium pyrophosphate, tribasic magnesium phosphate, tribasic calcium phosphate, aluminum hydroxide, alumina, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, zirconium silicate, synthetic resin type Examples include abrasives, among which one type or two or more types can be used in combination.

Wetting agents other than glycerin and sugar alcohol include diglycerin, polyglycerin, 1,3-butylene glycol, polyethylene glycol, 1,2-pentanediol, 1,3-hexanediol, propylene glycol, dipropylene glycol, and isopropylene. Examples include glycol, polypropylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, etc., and one or more of these can be used in combination.

Examples of the solvent include organic solvents such as ethanol, propyl alcohol, and isopropyl alcohol, and water. These solvents may be used alone or in combination of two or more.
As a binder, alginates and their derivatives such as carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate, ammonium alginate, xanthan gum, guar gum, Examples include agar, sodium carboxymethyl cellulose, hydroxyethyl cellulose, and sodium polyacrylate, and one or more of these can be used in combination.

Examples of fragrances include anethole, menthone, cineole, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinnamic aldehyde, trans-2-hexenal, etc., and one or more of these may be used in combination. It can be used as These components may be blended singly, but essential oils containing them may also be blended. In addition to the above-mentioned fragrance ingredients, fragrance ingredients such as aliphatic alcohols and their esters, terpene hydrocarbons, phenol ethers, aldehydes, ketones, and lactones, and essential oils may be blended within a range that does not impede the effects of the present invention.

Examples of excipients include sucrose, lactose, starch, glucose, crystalline cellulose, palatinose, trehalose, lactulose, coupling sugar, gum base, gum arabic, gelatin, cetyl methyl cellulose, light silicic anhydride, magnesium aluminate, Examples include calcium aluminate metasilicate, sodium hydrogen carbonate, and calcium phosphate.

Examples of sweeteners include saccharin sodium, aspartame, trehalose, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin, etc., and one or more of these can be used in combination. can.

Examples of pH adjusting agents include citric acid, phosphoric acid, pantothenic acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or chemically available compounds such as disodium hydrogen phosphate. Examples include salts and sodium hydroxide, and these can be used alone or in combination of two or more so that the pH of the composition is within an appropriate range.

Examples of preservatives include paraoxybenzoic acid esters, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, etc. One or two of these The above can be used in combination.

Examples of emulsifiers include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, sodium stearoyl lactate, and soybean. Examples include phospholipids and alkyltrimethylammonium chloride.
Examples of the solubilizing agent include esters, polyethylene glycol derivatives, polyoxyethylene hydrogenated castor oil, fatty acid esters of sorbitan, and sulfated fatty alcohols.

Foaming agents include sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-acylamino acid salts such as N-acylglutamate, 2-alkyl- N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxy Examples include ethylene fatty acid esters, among which one type or two or more types can be used in combination.
Examples of the lubricant include magnesium stearate, sucrose fatty acid ester, talc, and hydrogenated oil.
Examples of the oil include oils other than the essential oils used as antibacterial ingredients and the oils used as fragrances, such as coconut oil, olive oil, sesame oil, peanut oil, parsley oil, parsley seed oil, and safflower oil.

Examples of surfactants include sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, sucrose fatty acid ester, polyoxy Ethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, alkyl glycosides, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyl dimethyl amine oxide, lauryl ethanolamide, sodium cocoyl sarcosinate, N-lauroyl methyl taurine Examples include sodium solution.

Further, the oral composition of the present invention may contain further active ingredients. Such active ingredients include lysozyme chloride, tranexamic acid, sodium fluoride, potassium fluoride, sodium monofluorophosphate, polyethylene glycol, polyvinylpyrrolidone, zeolite, ascorbic acid, ascorbate salts, chlorhexidine salts, cetylpyridinium chloride, and benzyl chloride. Ruconium, benzethonium chloride, dequalinium chloride, isopropylmethylphenol, bisabolol, ascorbic acid and/or its derivatives, tocopherol acetate, ε-aminocaproic acid, aluminum hydroxyallantoin, aluminum lactate, potassium nitrate, dihydrocholesterol, copper chlorophyllin salt, sodium chloride, Examples include guaiazulene sulfonate, dextranase, pyridoxine hydrochloride, etc., and one or more of these can be blended.

In addition to the above, crude drug extracts may be added to the oral composition of the present invention.
Examples of herbal medicine extracts include chamomile extract, valerian extract, jujube extract, hop extract, lavender extract, linden extract, quince extract, goldenrod extract, kumazasa extract, gummy extract, clove extract, ginseng extract, Examples include salvia extract, Sapindrum extract, Bellflower extract, Rhododendron extract, Peony extract, Hawthorn extract, Angelica extract, Tea extract, Cucumber extract, Obesque extract, Birch extract, Carrot extract, Acacia extract, Turmeric extract, Rosemary extract, etc. Among them, one type or a combination of two or more types can be used.

The oral composition of the present invention can be manufactured according to a conventional method, and the manufacturing method is not particularly limited.
Further, the obtained oral composition can be used by filling an aluminum tube, a laminate tube, a glass vapor deposition tube, a plastic tube, a plastic bottle, an aerosol container, or the like.

Although the oral composition of the present invention has been described above, the present invention is not limited thereto. For example, the oral composition of the present invention may contain, in addition to the above-mentioned components, components having arbitrary functions.

Next, specific examples of the present invention will be described.
<Manufacture of oral composition>
(Examples 1 to 11, Comparative Examples 1 to 7)
The ingredients shown in Tables 1 and 2 were prepared to have the contents shown in Tables 1 and 2, and an oral composition (liquid dentifrice) was produced according to a conventional method.

<Evaluation method>
(Evaluation of refreshing feeling)
Ten test subjects used the oral compositions of each Example and each Comparative Example and evaluated them according to the following criteria, and evaluated using the average value according to the following criteria.
・Refreshing feeling (evaluation criteria)
5 points: Very refreshing sensation 4 points: Very refreshing sensation 3 points: Somewhat refreshing sensation 2 points: Almost no refreshing sensation 1 point: No refreshing sensation

・Average score evaluation ◎: Average score is 4.0 points or more ○: Average score is 3.0 points or more and less than 4.0 points △: Average score is 2.0 points or more and less than 3.0 points ×: Average score is Less than 2.0 points

(Taste evaluation)
Ten test subjects used the oral compositions of each Example and each Comparative Example and evaluated them according to the following criteria, and the average value was used to evaluate them according to the following criteria.
・Taste (evaluation criteria)
5 points: I don't feel any bitterness 4 points: I hardly feel any bitterness 3 points: I feel some bitterness 2 points: I feel some bitterness 1 point: I feel a lot of bitterness

・Average score evaluation ◎: Average score is 4.0 points or more ○: Average score is 3.0 points or more and less than 4.0 points △: Average score is 2.0 points or more and less than 3.0 points ×: Average score is Less than 2.0 points These results are shown in Tables 1 and 2.

As can be seen from Tables 1 and 2, the oral compositions of Examples had an excellent cooling sensation, suppressed the bitterness derived from the di-long chain cationic surfactant, and had an excellent feeling of use. On the other hand, in the comparative example, satisfactory results were not obtained.
In addition, for toothpaste toothpaste, toothpaste moisturizer, and mouthwash, the contents of component (A), component (B), and component (C) are the same as in each of the above examples and each comparative example. When a preparation was prepared and evaluated in the same manner as above, similar results were obtained.

Claims (7)

(A) Component: menthol or its derivative;
(B) Component: di-long chain cationic surfactant,
(C) Component: Contains sugar alcohol and/or glycerin,
The content of the component (A) is 0.01 to 1.5% by mass,
An oral composition in which the content of the component (B) is 0.005 to 1.5% by mass. The oral composition according to claim 1, wherein the component (A) is l-menthol. The oral composition according to claim 1, wherein the di-long chain cationic surfactant has 14 to 22 carbon atoms in one chain length. The oral composition according to claim 1, wherein the component (B) is distearyldimethylammonium or a salt thereof. The oral composition according to claim 4, wherein the component (B) is distearyldimethylammonium chloride. The oral composition according to claim 1, wherein the sugar alcohol is at least one selected from the group consisting of sorbitol, xylitol, erythritol, maltitol, and mannitol. The oral composition according to claim 1, which is a liquid dentifrice, a toothpaste, a moisturizing dentifrice, or a mouthwash.