JP2023166395A5 - - Google Patents
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- JP2023166395A5 JP2023166395A5 JP2023130710A JP2023130710A JP2023166395A5 JP 2023166395 A5 JP2023166395 A5 JP 2023166395A5 JP 2023130710 A JP2023130710 A JP 2023130710A JP 2023130710 A JP2023130710 A JP 2023130710A JP 2023166395 A5 JP2023166395 A5 JP 2023166395A5
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- Prior art keywords
- seq
- amino acid
- acid sequence
- set forth
- sequence set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000000611 antibody drug conjugate Substances 0.000 claims 4
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 4
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 229940116978 human epidermal growth factor Drugs 0.000 claims 1
Claims (3)
- 下記の構造を含む抗ヒト上皮成長因子受容体（ｈＥＧＦＲ）抗体薬物コンジュゲート（ＡＤＣ）。
配列番号１２に記載のアミノ酸配列を含む重鎖ＣＤＲ３ドメイン、配列番号１１に記載のアミノ酸配列を含む重鎖ＣＤＲ２ドメイン、及び配列番号１０に記載のアミノ酸配列を含む重鎖ＣＤＲ１ドメイン、並びに、
配列番号８に記載のアミノ酸配列を含む軽鎖ＣＤＲ３ドメイン、配列番号７に記載のアミノ酸配列を含む軽鎖ＣＤＲ２ドメイン、及び配列番号６に記載のアミノ酸配列を含む軽鎖ＣＤＲ１ドメイン
を含むＩｇＧ１抗ｈＥＧＦＲ抗体であって、ｍは２である。］ - 抗体が、配列番号９に記載のアミノ酸配列を含む重鎖可変領域、及び配列番号５に記載のアミノ酸配列を含む軽鎖可変領域を含む、請求項１に記載のＡＤＣ。
- 抗体が、配列番号１５に記載のアミノ酸配列を含む重鎖、及び配列番号１３に記載のアミノ酸配列を含む軽鎖を含む、請求項１又は２に記載のＡＤＣ。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347416P | 2016-06-08 | 2016-06-08 | |
| US62/347,416 | 2016-06-08 | ||
| JP2018564215A JP2019521106A (ja) | 2016-06-08 | 2017-06-07 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
| PCT/US2017/036368 WO2017214282A1 (en) | 2016-06-08 | 2017-06-07 | Anti-egfr antibody drug conjugates |
| JP2021201460A JP2022058351A (ja) | 2016-06-08 | 2021-12-13 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021201460A Division JP2022058351A (ja) | 2016-06-08 | 2021-12-13 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023166395A JP2023166395A (ja) | 2023-11-21 |
| JP2023166395A5 true JP2023166395A5 (ja) | 2024-02-21 |
Family
ID=59078219
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564215A Pending JP2019521106A (ja) | 2016-06-08 | 2017-06-07 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
| JP2021201460A Pending JP2022058351A (ja) | 2016-06-08 | 2021-12-13 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
| JP2023130710A Pending JP2023166395A (ja) | 2016-06-08 | 2023-08-10 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564215A Pending JP2019521106A (ja) | 2016-06-08 | 2017-06-07 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
| JP2021201460A Pending JP2022058351A (ja) | 2016-06-08 | 2021-12-13 | 抗ｅｇｆｒ抗体薬物コンジュゲート |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20190343961A1 (ja) |
| EP (2) | EP3468996B1 (ja) |
| JP (3) | JP2019521106A (ja) |
| KR (2) | KR20230035690A (ja) |
| CN (4) | CN109563168A (ja) |
| AU (2) | AU2017277517A1 (ja) |
| BR (1) | BR112018075636A2 (ja) |
| CA (1) | CA3027178A1 (ja) |
| CL (2) | CL2018003527A1 (ja) |
| CO (1) | CO2018013497A2 (ja) |
| CR (1) | CR20180614A (ja) |
| DO (2) | DOP2018000272A (ja) |
| EC (1) | ECSP19000157A (ja) |
| IL (3) | IL308054A (ja) |
| MX (2) | MX2018015286A (ja) |
| PE (1) | PE20190512A1 (ja) |
| PH (1) | PH12018502602A1 (ja) |
| RU (1) | RU2018147224A (ja) |
| SG (2) | SG10201914060WA (ja) |
| TW (3) | TW202423486A (ja) |
| WO (1) | WO2017214282A1 (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190153107A1 (en) * | 2016-06-08 | 2019-05-23 | Abbvie Inc. | Anti-egfr antibody drug conjugates |
| EP3468616A1 (en) * | 2016-06-08 | 2019-04-17 | AbbVie Inc. | Anti-egfr antibody drug conjugates |
| LT3458479T (lt) | 2016-06-08 | 2021-02-25 | Abbvie Inc. | Anti-b7-h3 antikūnai ir antikūnų vaisto konjugatai |
| CN118652192A (zh) * | 2017-05-24 | 2024-09-17 | 德克萨斯州大学系统董事会 | 用于抗体药物缀合物的接头 |
| EP3760233B1 (en) * | 2019-05-20 | 2023-07-12 | MabPlex International Co., Ltd. | One-pot preparation process for antibody drug conjugate intermediate |
| TW202100184A (zh) | 2019-05-20 | 2021-01-01 | 瑞士商諾華公司 | Mcl-1抑制劑抗體－藥物結合物及使用方法 |
| KR20210097627A (ko) | 2020-01-30 | 2021-08-09 | 성균관대학교산학협력단 | 면역관문 억제제 및 엑소좀 분비 억제제를 포함하는 항체-약물 접합체 및 이를 포함하는 약학적 조성물 |
| EP4153242B1 (en) | 2020-05-19 | 2024-05-15 | Les Laboratoires Servier | Para-amino-benzyl linkers, process for their preparation and their use in conjugates |
| CA3198996A1 (en) | 2020-11-24 | 2022-06-02 | Matthew T. Burger | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| EP4359440A1 (en) * | 2021-06-22 | 2024-05-01 | Regeneron Pharmaceuticals, Inc. | Anti-egfrviii antibody drug conjugates and uses thereof |
| WO2023208106A1 (zh) * | 2022-04-29 | 2023-11-02 | 石药集团中奇制药技术（石家庄）有限公司 | 具有肝靶向递送效应的化合物及其寡聚核苷酸缀合物 |
| WO2023223097A1 (en) | 2022-05-20 | 2023-11-23 | Novartis Ag | Antibody drug conjugates |
| WO2023225359A1 (en) | 2022-05-20 | 2023-11-23 | Novartis Ag | Antibody-drug conjugates of antineoplastic compounds and methods of use thereof |
| WO2024189481A1 (en) | 2023-03-10 | 2024-09-19 | Novartis Ag | Panras inhibitor antibody-drug conjugates and methods of use thereof |
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| US1726514A (en) | 1926-11-01 | 1929-08-27 | Firm Ferd Liebschner & Sohn | Picker for looms |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| ATE120454T1 (de) | 1988-06-14 | 1995-04-15 | Cetus Oncology Corp | Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus. |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| US5124471A (en) | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| AU3657899A (en) | 1998-04-20 | 1999-11-08 | James E. Bailey | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| ES2571230T3 (es) | 1999-04-09 | 2016-05-24 | Kyowa Hakko Kirin Co Ltd | Procedimiento para controlar la actividad de una molécula inmunofuncional |
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| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
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| WO2003016466A2 (en) | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | ANTI-Aβ ANTIBODIES |
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| WO2004019993A1 (en) | 2002-08-30 | 2004-03-11 | Ramot At Tel Aviv University Ltd. | Self-immolative dendrimers releasing many active moieties upon a single activating event |
| WO2004043493A1 (en) | 2002-11-14 | 2004-05-27 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
| AU2004213053C1 (en) | 2003-02-20 | 2009-07-16 | Seagen Inc. | Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| JP5064037B2 (ja) | 2004-02-23 | 2012-10-31 | ジェネンテック， インコーポレイテッド | 複素環式自壊的リンカーおよび結合体 |
| CN104611245A (zh) | 2004-04-15 | 2015-05-13 | 格利科菲公司 | 在低等真核生物中产生半乳糖基化糖蛋白 |
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-
2017
- 2017-06-07 CN CN201780048216.7A patent/CN109563168A/zh active Pending
- 2017-06-07 RU RU2018147224A patent/RU2018147224A/ru not_active Application Discontinuation
- 2017-06-07 SG SG10201914060WA patent/SG10201914060WA/en unknown
- 2017-06-07 BR BR112018075636-9A patent/BR112018075636A2/pt unknown
- 2017-06-07 TW TW113107949A patent/TW202423486A/zh unknown
- 2017-06-07 JP JP2018564215A patent/JP2019521106A/ja active Pending
- 2017-06-07 SG SG11201810970WA patent/SG11201810970WA/en unknown
- 2017-06-07 CA CA3027178A patent/CA3027178A1/en active Pending
- 2017-06-07 EP EP17731394.7A patent/EP3468996B1/en not_active Withdrawn - After Issue
- 2017-06-07 CN CN202211269863.XA patent/CN116059394A/zh active Pending
- 2017-06-07 KR KR1020237007108A patent/KR20230035690A/ko active Application Filing
- 2017-06-07 TW TW111128039A patent/TW202320860A/zh unknown
- 2017-06-07 CN CN202211269794.2A patent/CN116059202A/zh active Pending
- 2017-06-07 TW TW106118952A patent/TW201806626A/zh unknown
- 2017-06-07 MX MX2018015286A patent/MX2018015286A/es unknown
- 2017-06-07 US US16/308,463 patent/US20190343961A1/en not_active Abandoned
- 2017-06-07 CR CR20180614A patent/CR20180614A/es unknown
- 2017-06-07 KR KR1020197000330A patent/KR20190015526A/ko active IP Right Grant
- 2017-06-07 CN CN202211269635.2A patent/CN116059201A/zh active Pending
- 2017-06-07 EP EP22166591.2A patent/EP4104865A1/en active Pending
- 2017-06-07 AU AU2017277517A patent/AU2017277517A1/en not_active Abandoned
- 2017-06-07 IL IL308054A patent/IL308054A/en unknown
- 2017-06-07 PE PE2018003191A patent/PE20190512A1/es unknown
- 2017-06-07 WO PCT/US2017/036368 patent/WO2017214282A1/en unknown
-
2018
- 2018-12-07 IL IL263571A patent/IL263571A/en unknown
- 2018-12-07 MX MX2022007807A patent/MX2022007807A/es unknown
- 2018-12-07 DO DO2018000272A patent/DOP2018000272A/es unknown
- 2018-12-07 CL CL2018003527A patent/CL2018003527A1/es unknown
- 2018-12-10 PH PH12018502602A patent/PH12018502602A1/en unknown
- 2018-12-13 CO CONC2018/0013497A patent/CO2018013497A2/es unknown
-
2019
- 2019-01-03 EC ECSENADI2019157A patent/ECSP19000157A/es unknown
- 2019-08-09 CL CL2019002270A patent/CL2019002270A1/es unknown
-
2021
- 2021-09-10 US US17/447,362 patent/US20230077680A1/en not_active Abandoned
- 2021-12-13 JP JP2021201460A patent/JP2022058351A/ja active Pending
-
2022
- 2022-03-02 IL IL291073A patent/IL291073A/en unknown
- 2022-09-09 DO DO2022000182A patent/DOP2022000182A/es unknown
-
2023
- 2023-08-10 JP JP2023130710A patent/JP2023166395A/ja active Pending
-
2024
- 2024-07-20 AU AU2024205004A patent/AU2024205004A1/en active Pending
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