JP2023055809A5 - - Google Patents
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- JP2023055809A5 JP2023055809A5 JP2023011523A JP2023011523A JP2023055809A5 JP 2023055809 A5 JP2023055809 A5 JP 2023055809A5 JP 2023011523 A JP2023011523 A JP 2023011523A JP 2023011523 A JP2023011523 A JP 2023011523A JP 2023055809 A5 JP2023055809 A5 JP 2023055809A5
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- JP
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- Prior art keywords
- trans
- cancer
- vector
- cell
- rna molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 62
- 239000013598 vector Substances 0.000 claims description 42
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- 108090000623 proteins and genes Proteins 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 239000002773 nucleotide Substances 0.000 claims description 13
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- 241000700605 Viruses Species 0.000 claims description 10
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- 208000002903 Thalassemia Diseases 0.000 claims description 2
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1605586.5 | 2016-04-01 | ||
| GB201605586 | 2016-04-01 | ||
| PCT/SG2017/050183 WO2017171654A1 (en) | 2016-04-01 | 2017-03-31 | Trans-splicing rna (tsrna) |
| JP2018551404A JP7229467B2 (ja) | 2016-04-01 | 2017-03-31 | トランス－スプライシングＲＮＡ（ｔｓＲＮＡ） |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551404A Division JP7229467B2 (ja) | 2016-04-01 | 2017-03-31 | トランス－スプライシングＲＮＡ（ｔｓＲＮＡ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023055809A JP2023055809A (ja) | 2023-04-18 |
| JP2023055809A5 true JP2023055809A5 (enExample) | 2023-05-25 |
| JP7570125B2 JP7570125B2 (ja) | 2024-10-21 |
Family
ID=59966148
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551404A Active JP7229467B2 (ja) | 2016-04-01 | 2017-03-31 | トランス－スプライシングＲＮＡ（ｔｓＲＮＡ） |
| JP2023011523A Active JP7570125B2 (ja) | 2016-04-01 | 2023-01-30 | トランス－スプライシングＲＮＡ（ｔｓＲＮＡ） |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551404A Active JP7229467B2 (ja) | 2016-04-01 | 2017-03-31 | トランス－スプライシングＲＮＡ（ｔｓＲＮＡ） |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11517583B2 (enExample) |
| EP (1) | EP3436590A4 (enExample) |
| JP (2) | JP7229467B2 (enExample) |
| CN (1) | CN109642241B (enExample) |
| AU (1) | AU2017240703B2 (enExample) |
| SG (1) | SG11201808538QA (enExample) |
| WO (1) | WO2017171654A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021076656A1 (en) * | 2019-10-15 | 2021-04-22 | University Of Massachusetts | Rna editor-enhanced rna trans-splicing |
| EP4100533A1 (en) * | 2020-02-07 | 2022-12-14 | University of Rochester | Ribozyme-mediated rna assembly and expression |
| GB202102118D0 (en) | 2021-02-15 | 2021-03-31 | Cambridge Entpr Ltd | RNA Trans-Splicing molecule |
| EP4323391A4 (en) * | 2021-04-15 | 2025-04-16 | Tacit Therapeutics, Inc. | HIGH-EFFICIENCY TRANS-SPLICING FOR TARGETED RNA SEQUENCE REPLACEMENT IN HUMAN CELLS |
| GB202108855D0 (en) | 2021-06-21 | 2021-08-04 | Cambridge Entpr Ltd | Methods of eukaryotic gene expression |
| CN113584169B (zh) * | 2021-07-28 | 2024-06-18 | 南京大学 | 一种与肝癌相关的血清tsRNA标志物、探针及其应用 |
| JP2024533163A (ja) * | 2021-09-03 | 2024-09-12 | タシト・セラピューティクス・インコーポレーテッド | スプライソソーム構成要素のリクルートを介したｒｎａ編集 |
| US20250145990A1 (en) * | 2022-01-18 | 2025-05-08 | National University Of Singapore | Trans-splicing rna (tsrna) |
| KR20250011939A (ko) | 2022-05-13 | 2025-01-22 | 아시디엔 테라퓨틱스, 인크. | Abca4 트랜스-스플라이싱 분자 |
| EP4558631A4 (en) * | 2022-07-19 | 2026-07-15 | Tacit Therapeutics Inc | SYSTEMS AND METHODS TO PROMOTE TRANS-SPLICING |
| CN122206801A (zh) * | 2023-10-18 | 2026-06-12 | 泰思特治疗公司 | 反式剪接核酸分子及其使用方法 |
| CN118813791A (zh) * | 2024-09-14 | 2024-10-22 | 中国人民解放军总医院第二医学中心 | 用于诊断寒冷暴露致心肌损伤的生物标志物、试剂盒及应用 |
| EP4756023A1 (en) * | 2024-12-06 | 2026-06-10 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Self-cleavable ribozyme therapeutic nucleic acid molecules |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0883344B2 (en) * | 1995-12-15 | 2010-06-09 | VIRxSYS Corporation | Therapeutic molecules generated by trans-splicing |
| US6280978B1 (en) * | 1995-12-15 | 2001-08-28 | Intronn Holdings, Llc | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| DE10139492B4 (de) * | 2001-08-13 | 2004-06-09 | Eul, Joachim, Dr. | Verfahren zur Reparatur einer mutierten RNA aus einer gendefekten DNA und zum gezielten Abtöten von Tumorzellen durch RNA-Transspleißen sowie Verfahren zum Nachweis von natürlich-transgespleißter zellulärer RNA |
| ATE506436T1 (de) * | 2002-04-30 | 2011-05-15 | Icon Genetics Gmbh | Auf trans-splicing basierende amplifikationsvectoren |
| WO2003104412A2 (en) * | 2002-06-05 | 2003-12-18 | Intronn, Inc. | Spliceosome mediated rna trans-splicing and correction of factor viii genetic defects using spliceosome mediated rna trans spling |
| AU2003285009B2 (en) * | 2002-10-23 | 2010-10-07 | Virxsys Corporation | Screening methods for identification of efficient pre-trans-splicing molecules |
| US7192709B2 (en) * | 2004-03-15 | 2007-03-20 | Digigenomics Co., Ltd. | Methods for identification, assessment, prevention, and therapy of cancer |
| KR100958293B1 (ko) * | 2008-03-27 | 2010-05-19 | 단국대학교 산학협력단 | 테오필린에 의해 표적 특이적 ｒｎａ 치환 활성이 조절되는알로스테릭 트랜스―스플라이싱 그룹 ｉ 리보자임 |
| KR20110036996A (ko) * | 2009-10-05 | 2011-04-13 | 전남대학교산학협력단 | 편평세포암 진단 마커인 ｈｏ-1 및 이의 용도 |
| WO2012056441A1 (en) * | 2010-10-28 | 2012-05-03 | Nanodoc Ltd. | Compositions and methods for specific cleavage of exogenous rna in a cell |
| JP2014525754A (ja) * | 2011-08-12 | 2014-10-02 | バイレクシス コーポレイション | アポトーシスを誘導するための組成物および方法 |
| KR101293620B1 (ko) | 2011-08-19 | 2013-08-13 | 국립암센터 | 트랜스-스플라이싱 라이보자임 및 암치료 유전자를 포함하는 재조합 아데노바이러스 및 이의 용도 |
| GB201219762D0 (en) * | 2012-11-02 | 2012-12-19 | Bauer Johann | A RNA trans-splicing molecule (RTM) for use in the treatment of cancer |
| KR101429696B1 (ko) * | 2012-11-21 | 2014-08-13 | 국립암센터 | 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도 |
| US20140283156A1 (en) * | 2013-03-14 | 2014-09-18 | Cold Spring Harbor Laboratory | Trans-splicing ribozymes and silent recombinases |
-
2017
- 2017-03-31 WO PCT/SG2017/050183 patent/WO2017171654A1/en not_active Ceased
- 2017-03-31 JP JP2018551404A patent/JP7229467B2/ja active Active
- 2017-03-31 US US16/090,226 patent/US11517583B2/en active Active
- 2017-03-31 EP EP17776008.9A patent/EP3436590A4/en active Pending
- 2017-03-31 SG SG11201808538QA patent/SG11201808538QA/en unknown
- 2017-03-31 AU AU2017240703A patent/AU2017240703B2/en active Active
- 2017-03-31 CN CN201780034177.5A patent/CN109642241B/zh active Active
-
2022
- 2022-11-10 US US17/984,846 patent/US20240075051A1/en active Pending
-
2023
- 2023-01-30 JP JP2023011523A patent/JP7570125B2/ja active Active
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