JP2023038235A5 - - Google Patents
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- JP2023038235A5 JP2023038235A5 JP2023000803A JP2023000803A JP2023038235A5 JP 2023038235 A5 JP2023038235 A5 JP 2023038235A5 JP 2023000803 A JP2023000803 A JP 2023000803A JP 2023000803 A JP2023000803 A JP 2023000803A JP 2023038235 A5 JP2023038235 A5 JP 2023038235A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pep
- attached
- gly
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510370P | 2017-05-24 | 2017-05-24 | |
| US62/510,370 | 2017-05-24 | ||
| US201762557881P | 2017-09-13 | 2017-09-13 | |
| US62/557,881 | 2017-09-13 | ||
| JP2019565169A JP2020520981A (ja) | 2017-05-24 | 2018-05-23 | プロテアーゼのイメージング／検出のための化学発光プローブ |
| PCT/IL2018/050557 WO2018216012A1 (en) | 2017-05-24 | 2018-05-23 | Chemiluminescent probes for imaging/detection of proteases |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565169A Division JP2020520981A (ja) | 2017-05-24 | 2018-05-23 | プロテアーゼのイメージング／検出のための化学発光プローブ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023038235A JP2023038235A (ja) | 2023-03-16 |
| JP2023038235A5 true JP2023038235A5 (https=) | 2023-07-07 |
| JP7553615B2 JP7553615B2 (ja) | 2024-09-18 |
Family
ID=64396284
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565169A Pending JP2020520981A (ja) | 2017-05-24 | 2018-05-23 | プロテアーゼのイメージング／検出のための化学発光プローブ |
| JP2023000803A Active JP7553615B2 (ja) | 2017-05-24 | 2023-01-06 | プロテアーゼのイメージング／検出のための化学発光プローブ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565169A Pending JP2020520981A (ja) | 2017-05-24 | 2018-05-23 | プロテアーゼのイメージング／検出のための化学発光プローブ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12173350B2 (https=) |
| EP (1) | EP3630742B1 (https=) |
| JP (2) | JP2020520981A (https=) |
| CN (1) | CN110944985B (https=) |
| ES (1) | ES2963606T3 (https=) |
| PL (1) | PL3630742T3 (https=) |
| WO (1) | WO2018216012A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3802511A1 (en) * | 2018-05-25 | 2021-04-14 | Nemis Technologies AG | Dioxetane compounds and their use for the detection of microorganisms |
| US20230094870A1 (en) * | 2020-02-19 | 2023-03-30 | Ramot At Tel-Aviv University Ltd. | Chemiluminescence probes for tuberculosis |
| US20240277873A1 (en) * | 2021-08-11 | 2024-08-22 | Nanyang Technological University | Ultrabright chemiluminescent probes for detection and imaging |
| CN114315791B (zh) * | 2021-12-22 | 2023-12-08 | 东南大学 | 用于实现手术导航和微小转移瘤成像的小分子化学发光探针及其制备方法和用途 |
| CN114380786B (zh) * | 2021-12-23 | 2023-03-24 | 苏州大学 | 基于氨基肽酶激活型化学发光探针及其在恶性肿瘤的活体检测与手术导航方面的应用 |
| CN114716407A (zh) * | 2022-03-16 | 2022-07-08 | 大连理工大学 | 一种检测泛酰巯基乙胺酶活性的化学发光探针、制备方法及其生物应用 |
| CN115819416B (zh) * | 2022-11-29 | 2024-06-25 | 遵义医科大学 | 一种用于检测和区分的多模态化学发光分子及其应用 |
| WO2024147125A1 (en) * | 2023-01-04 | 2024-07-11 | Ramot At Tel-Aviv University Ltd. | Cyclobutyl-substituted phenoxy-dioxetanes and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| PE20011267A1 (es) * | 2000-03-29 | 2001-12-15 | Vertex Pharma | Carbamato como inhibidores de caspasa |
| UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
| US9695251B2 (en) * | 2003-10-31 | 2017-07-04 | The Regents Of The University Of California | Activatable cell penetrating peptides with quenched fluorophores |
| US20100278745A1 (en) * | 2006-12-21 | 2010-11-04 | Norbert Lange | Compounds for fluorescence imaging |
| WO2009019115A1 (en) * | 2007-08-03 | 2009-02-12 | Sanofi-Aventis | Caspase imaging probes |
| ES2658852T3 (es) * | 2008-01-18 | 2018-03-12 | Visen Medical, Inc. | Agentes de imaginología fluorescentes |
| NZ611656A (en) | 2010-12-29 | 2014-10-31 | Arrowhead Res Corp | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
| WO2012123916A2 (en) * | 2011-03-15 | 2012-09-20 | Ramot At Tel-Aviv University Ltd. | Activatable fluorogenic compounds and uses thereof as near infrared probes |
| FR3022784B1 (fr) * | 2014-06-26 | 2017-09-08 | Ecole Normale Superieure Lyon | Sondes moleculaires activables hydrosolubles, intermediaires pour leur synthese et procedes de detection associes |
| EP3408349B1 (en) * | 2016-01-26 | 2021-03-31 | Ramot at Tel-Aviv University Ltd. | Chemiluminescent fluorophor-linked adamantylene-dioxetane probes as diagnostics or in-vivo imaging sensors |
| EP3802511A1 (en) * | 2018-05-25 | 2021-04-14 | Nemis Technologies AG | Dioxetane compounds and their use for the detection of microorganisms |
-
2018
- 2018-05-23 CN CN201880047726.7A patent/CN110944985B/zh active Active
- 2018-05-23 WO PCT/IL2018/050557 patent/WO2018216012A1/en not_active Ceased
- 2018-05-23 ES ES18804980T patent/ES2963606T3/es active Active
- 2018-05-23 EP EP18804980.3A patent/EP3630742B1/en active Active
- 2018-05-23 US US16/616,356 patent/US12173350B2/en active Active
- 2018-05-23 JP JP2019565169A patent/JP2020520981A/ja active Pending
- 2018-05-23 PL PL18804980.3T patent/PL3630742T3/pl unknown
-
2023
- 2023-01-06 JP JP2023000803A patent/JP7553615B2/ja active Active
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