JP2023030113A5 - - Google Patents

Info

Publication number

JP2023030113A5

JP2023030113A5 JP2022205904A JP2022205904A JP2023030113A5 JP 2023030113 A5 JP2023030113 A5 JP 2023030113A5 JP 2022205904 A JP2022205904 A JP 2022205904A JP 2022205904 A JP2022205904 A JP 2022205904A JP 2023030113 A5 JP2023030113 A5 JP 2023030113A5

Authority

JP

Japan

Prior art keywords

therapeutic agent

pharmaceutical combination

compound

subject

phenanthro

Prior art date

2022-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 claims 18
• 229940124597 therapeutic agent Drugs 0.000 claims 18
• 150000001875 compounds Chemical class 0.000 claims 11
• 150000003839 salts Chemical class 0.000 claims 6
• 238000000034 method Methods 0.000 claims 4
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 3
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 3
• 201000002909 Aspergillosis Diseases 0.000 claims 3
• 208000036641 Aspergillus infections Diseases 0.000 claims 3
• 239000005973 Carvone Substances 0.000 claims 3
• 208000000785 Invasive Pulmonary Aspergillosis Diseases 0.000 claims 3
• 239000002253 acid Substances 0.000 claims 3
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 3
• 229960003942 amphotericin b Drugs 0.000 claims 3
• 229960004130 itraconazole Drugs 0.000 claims 3
• 229960001589 posaconazole Drugs 0.000 claims 3
• RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims 3
• 230000002265 prevention Effects 0.000 claims 3
• BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 3
• 229960004740 voriconazole Drugs 0.000 claims 3
• OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims 1
• 241000228212 Aspergillus Species 0.000 claims 1
• 241000228257 Aspergillus sp. Species 0.000 claims 1
• 229920000926 Galactomannan Polymers 0.000 claims 1
• 210000002421 cell wall Anatomy 0.000 claims 1