CA3059225A1 - Antifungal agents used in combination - Google Patents
Antifungal agents used in combination Download PDFInfo
- Publication number
- CA3059225A1 CA3059225A1 CA3059225A CA3059225A CA3059225A1 CA 3059225 A1 CA3059225 A1 CA 3059225A1 CA 3059225 A CA3059225 A CA 3059225A CA 3059225 A CA3059225 A CA 3059225A CA 3059225 A1 CA3059225 A1 CA 3059225A1
- Authority
- CA
- Canada
- Prior art keywords
- therapeutic agent
- pharmaceutical combination
- subject
- formula
- amphotericin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003429 antifungal agent Substances 0.000 title abstract description 37
- 150000001875 compounds Chemical class 0.000 claims abstract description 98
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- 229960003942 amphotericin b Drugs 0.000 claims abstract description 43
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
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| US201762483647P | 2017-04-10 | 2017-04-10 | |
| US62/483,647 | 2017-04-10 | ||
| PCT/US2018/026088 WO2018191077A1 (en) | 2017-04-10 | 2018-04-04 | Antifungal agents used in combination |
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| CA3059225A1 true CA3059225A1 (en) | 2018-10-18 |
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| EP3661503B1 (en) * | 2017-08-04 | 2022-09-07 | Scynexis, Inc. | Antifungal agents with enhanced activity in acidic ph |
| CN113631165A (zh) * | 2019-02-27 | 2021-11-09 | 西尼克斯公司 | 用于治疗或预防肺囊虫属肺炎的三萜类抗真菌剂 |
| CA3140637A1 (en) * | 2019-05-16 | 2020-11-19 | Scynexis, Inc. | Antifungal agents, like ibrexafungerp for candida auris decolonization |
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| US5756472A (en) | 1996-01-31 | 1998-05-26 | Merck & Co., Inc. | Antifungal agent obtained from hormonema |
| AU2007245024B2 (en) | 2006-04-03 | 2012-09-06 | Scynexis, Inc. | Antifungal agents |
| CN104877001B (zh) * | 2008-08-12 | 2020-07-03 | 西尼克斯公司 | 抗真菌制剂 |
| EA018337B1 (ru) * | 2008-08-12 | 2013-07-30 | Мерк Шарп Энд Дом Корп. | Противогрибковые средства |
| AU2015348043B2 (en) * | 2014-11-21 | 2019-08-22 | F2G Limited | Antifungal agents |
| US10174074B2 (en) | 2015-01-19 | 2019-01-08 | Scynexis, Inc. | Salts and polymorphs of SCY-078 |
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| JP7263313B2 (ja) | 2023-04-24 |
| KR20240110109A (ko) | 2024-07-12 |
| US11110102B2 (en) | 2021-09-07 |
| EA201992413A1 (ru) | 2020-03-16 |
| MA49889A (fr) | 2020-06-24 |
| KR102683355B1 (ko) | 2024-07-10 |
| CN110769854A (zh) | 2020-02-07 |
| JP2020513037A (ja) | 2020-04-30 |
| US20180325919A1 (en) | 2018-11-15 |
| KR20190133251A (ko) | 2019-12-02 |
| CN110769854B (zh) | 2023-01-13 |
| AU2018253031A1 (en) | 2019-10-31 |
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