JP2023021268A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2023021268A5 JP2023021268A5 JP2022198452A JP2022198452A JP2023021268A5 JP 2023021268 A5 JP2023021268 A5 JP 2023021268A5 JP 2022198452 A JP2022198452 A JP 2022198452A JP 2022198452 A JP2022198452 A JP 2022198452A JP 2023021268 A5 JP2023021268 A5 JP 2023021268A5
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethyl
- methylmorpholin
- pyridin
- alkyl
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- -1 methoxy, dimethylamino, trifluoromethylmethoxy Chemical group 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 1
- KIRRPVVLWZDEOM-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-(2-methylpyrazol-3-yl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)C=1N(N=CC=1)C)C(F)(F)F)=O KIRRPVVLWZDEOM-UHFFFAOYSA-N 0.000 claims 1
- YAGDPINTXNUJFA-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-(oxolan-3-ylsulfonyl)-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)C1COCC1)C(F)(F)F)=O YAGDPINTXNUJFA-UHFFFAOYSA-N 0.000 claims 1
- BPXSDXXWOWIEGU-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-methylsulfonyl-2-(trifluoromethyl)phenyl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)C1=C(C=C(C=C1)S(=O)(=O)C)C(F)(F)F)=O BPXSDXXWOWIEGU-UHFFFAOYSA-N 0.000 claims 1
- LTTGFQYAQYEYHW-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-methylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)C)C(F)(F)F)=O LTTGFQYAQYEYHW-UHFFFAOYSA-N 0.000 claims 1
- GEQMLAFCKWRJLD-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-morpholin-4-ylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)N1CCOCC1)C(F)(F)F)=O GEQMLAFCKWRJLD-UHFFFAOYSA-N 0.000 claims 1
- VGAYOERTTXJDOP-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-piperidin-1-ylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)N1CCCCC1)C(F)(F)F)=O VGAYOERTTXJDOP-UHFFFAOYSA-N 0.000 claims 1
- FKHNSGHHGRJGMU-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-pyrrolidin-1-ylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)N1CCCC1)C(F)(F)F)=O FKHNSGHHGRJGMU-UHFFFAOYSA-N 0.000 claims 1
- YRXRLABGSILYCG-UHFFFAOYSA-N 6-[4-(1,2-dimethylimidazol-4-yl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound CN1C(=NC(=C1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F)C YRXRLABGSILYCG-UHFFFAOYSA-N 0.000 claims 1
- JAVRYPHODLVYTQ-UHFFFAOYSA-N 6-[4-(1-methylcyclopropyl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound CC1(CC1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F JAVRYPHODLVYTQ-UHFFFAOYSA-N 0.000 claims 1
- YLNDUJZNLZBUIQ-UHFFFAOYSA-N 6-[4-(2-methoxyethylsulfonyl)-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound COCCS(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F YLNDUJZNLZBUIQ-UHFFFAOYSA-N 0.000 claims 1
- LMMZDANJUDIECD-UHFFFAOYSA-N 6-[4-(4-fluorophenyl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound FC1=CC=C(C=C1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F LMMZDANJUDIECD-UHFFFAOYSA-N 0.000 claims 1
- AYEISBMTIDMDIW-UHFFFAOYSA-N 6-[4-(5-fluoropyridin-3-yl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound FC=1C=C(C=NC=1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F AYEISBMTIDMDIW-UHFFFAOYSA-N 0.000 claims 1
- MCOXRIXWEFCOLO-UHFFFAOYSA-N 6-[4-[(4-fluorophenyl)methylsulfonyl]-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound FC1=CC=C(C=C1)CS(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F MCOXRIXWEFCOLO-UHFFFAOYSA-N 0.000 claims 1
- VUXZPNNEUUVZLC-UHFFFAOYSA-N 6-[4-cyclopropylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound C1(CC1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F VUXZPNNEUUVZLC-UHFFFAOYSA-N 0.000 claims 1
- HJXFEQOSKUTUOT-UHFFFAOYSA-N N,N-dimethyl-4-[4-(3-methylmorpholin-4-yl)-6-oxo-1H-pyridin-2-yl]-3-(trifluoromethyl)benzenesulfonamide Chemical compound CN(S(=O)(=O)C1=CC(=C(C=C1)C=1NC(C=C(C=1)N1C(COCC1)C)=O)C(F)(F)F)C HJXFEQOSKUTUOT-UHFFFAOYSA-N 0.000 claims 1
- BFZZOZQOAVINFN-UHFFFAOYSA-N N,N-dimethyl-4-[4-(3-methylmorpholin-4-yl)-6-oxo-1H-pyridin-2-yl]-3-(trifluoromethyl)piperazine-1-sulfonamide Chemical compound CN(S(=O)(=O)N1CC(N(CC1)C=1NC(C=C(C=1)N1C(COCC1)C)=O)C(F)(F)F)C BFZZOZQOAVINFN-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17187567.7 | 2017-08-23 | ||
| EP17187567 | 2017-08-23 | ||
| JP2020510087A JP7199736B2 (ja) | 2017-08-23 | 2018-08-23 | モルホリニルピリドン化合物 |
| PCT/EP2018/072791 WO2019038390A1 (en) | 2017-08-23 | 2018-08-23 | MORPHOLINYLPYRIDONE COMPOUNDS |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510087A Division JP7199736B2 (ja) | 2017-08-23 | 2018-08-23 | モルホリニルピリドン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023021268A JP2023021268A (ja) | 2023-02-10 |
| JP2023021268A5 true JP2023021268A5 (https=) | 2023-09-25 |
Family
ID=59686888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510087A Active JP7199736B2 (ja) | 2017-08-23 | 2018-08-23 | モルホリニルピリドン化合物 |
| JP2022198452A Ceased JP2023021268A (ja) | 2017-08-23 | 2022-12-13 | モルホリニルピリドン化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510087A Active JP7199736B2 (ja) | 2017-08-23 | 2018-08-23 | モルホリニルピリドン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11560374B2 (https=) |
| EP (2) | EP3672962B1 (https=) |
| JP (2) | JP7199736B2 (https=) |
| KR (1) | KR102732013B1 (https=) |
| CN (3) | CN116462674A (https=) |
| AU (2) | AU2018320419B2 (https=) |
| CY (1) | CY1125117T1 (https=) |
| DK (1) | DK3672962T3 (https=) |
| ES (1) | ES2910157T3 (https=) |
| HR (1) | HRP20220497T1 (https=) |
| HU (1) | HUE058661T2 (https=) |
| IL (3) | IL302077A (https=) |
| LT (1) | LT3672962T (https=) |
| PL (1) | PL3672962T3 (https=) |
| PT (1) | PT3672962T (https=) |
| RS (1) | RS63109B1 (https=) |
| SI (1) | SI3672962T1 (https=) |
| SM (1) | SMT202200169T1 (https=) |
| TW (2) | TW202348601A (https=) |
| WO (1) | WO2019038390A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3199999A1 (en) | 2020-11-25 | 2022-06-02 | Deciphera Pharmaceuticals, Llc | Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection |
| CN117241800A (zh) * | 2020-11-25 | 2023-12-15 | 德西费拉制药有限责任公司 | Vps34抑制剂的抗病毒活性 |
| CN117241829A (zh) * | 2020-11-25 | 2023-12-15 | 德西费拉制药有限责任公司 | Vps34抑制剂的抗病毒活性 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2581454A1 (en) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyrimidine compounds, process for their preparation and compositions containing them |
| WO2011058478A1 (en) * | 2009-11-16 | 2011-05-19 | Pfizer Inc. | Substituted triazolopyrimidines as pde8 inhibitors |
| WO2012085815A1 (en) | 2010-12-21 | 2012-06-28 | Novartis Ag | Bi-heteroaryl compounds as vps34 inhibitors |
| DK2655375T3 (en) * | 2010-12-23 | 2015-03-09 | Sanofi Sa | PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF |
| FR2969612B1 (fr) * | 2010-12-23 | 2013-02-08 | Sanofi Aventis | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique |
| GB201120317D0 (en) | 2011-11-24 | 2012-01-04 | Queen Mary & Westfield College | Screening method |
| FR2992314B1 (fr) * | 2012-06-22 | 2015-10-16 | Sanofi Sa | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique |
| JP6074043B2 (ja) * | 2013-08-29 | 2017-02-01 | 富士フイルム株式会社 | 新規なモルホリン誘導体またはその塩 |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| WO2015108861A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
| ES2821400T3 (es) | 2016-02-19 | 2021-04-26 | Sprint Bioscience Ab | Compuestos de 6-heterociclil-4-morfolin-4-ilpiridin-2-ona útiles para el tratamiento del cáncer y la diabetes |
| TWI721104B (zh) | 2016-02-19 | 2021-03-11 | 瑞典商斯普林特生物科技公司 | 6‐芳基或6‐雜芳基‐4‐嗎啉‐4‐芳基‐吡啶‐2‐酮化合物 |
-
2018
- 2018-08-23 SI SI201830624T patent/SI3672962T1/sl unknown
- 2018-08-23 PT PT187591052T patent/PT3672962T/pt unknown
- 2018-08-23 RS RS20220357A patent/RS63109B1/sr unknown
- 2018-08-23 TW TW112116474A patent/TW202348601A/zh unknown
- 2018-08-23 HU HUE18759105A patent/HUE058661T2/hu unknown
- 2018-08-23 HR HRP20220497TT patent/HRP20220497T1/hr unknown
- 2018-08-23 US US16/639,902 patent/US11560374B2/en active Active
- 2018-08-23 EP EP18759105.2A patent/EP3672962B1/en active Active
- 2018-08-23 CN CN202310448740.0A patent/CN116462674A/zh active Pending
- 2018-08-23 TW TW107129499A patent/TWI803511B/zh not_active IP Right Cessation
- 2018-08-23 LT LTEPPCT/EP2018/072791T patent/LT3672962T/lt unknown
- 2018-08-23 WO PCT/EP2018/072791 patent/WO2019038390A1/en not_active Ceased
- 2018-08-23 CN CN201880060742.XA patent/CN111108102B/zh active Active
- 2018-08-23 CN CN202310448700.6A patent/CN116444510A/zh active Pending
- 2018-08-23 AU AU2018320419A patent/AU2018320419B2/en not_active Ceased
- 2018-08-23 JP JP2020510087A patent/JP7199736B2/ja active Active
- 2018-08-23 EP EP22153292.2A patent/EP4056569A1/en not_active Withdrawn
- 2018-08-23 KR KR1020207007564A patent/KR102732013B1/ko active Active
- 2018-08-23 SM SM20220169T patent/SMT202200169T1/it unknown
- 2018-08-23 PL PL18759105T patent/PL3672962T3/pl unknown
- 2018-08-23 IL IL302077A patent/IL302077A/en unknown
- 2018-08-23 ES ES18759105T patent/ES2910157T3/es active Active
- 2018-08-23 DK DK18759105.2T patent/DK3672962T3/da active
-
2020
- 2020-02-20 IL IL272815A patent/IL272815B/en unknown
-
2022
- 2022-04-14 CY CY20221100283T patent/CY1125117T1/el unknown
- 2022-04-25 IL IL292489A patent/IL292489B2/en unknown
- 2022-12-13 JP JP2022198452A patent/JP2023021268A/ja not_active Ceased
- 2022-12-19 US US18/084,208 patent/US20230234949A1/en not_active Abandoned
-
2023
- 2023-12-22 AU AU2023285995A patent/AU2023285995A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023021268A5 (https=) | ||
| JP2021504443A5 (https=) | ||
| JP2019533694A5 (https=) | ||
| JP2005538955A5 (https=) | ||
| JP2017525757A5 (https=) | ||
| RU2017145929A (ru) | МОДУЛЯТОРЫ ROR ГАММА(RORγ) | |
| JP2019070032A5 (https=) | ||
| RU2010110640A (ru) | Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ | |
| JP2004524301A5 (https=) | ||
| RU2003131693A (ru) | Новые ингибиторы тирозин киназ | |
| JP2010533160A5 (https=) | ||
| JP2009526072A5 (https=) | ||
| JP2007504160A5 (https=) | ||
| JP2017529346A5 (https=) | ||
| JP2007519692A5 (https=) | ||
| JP2016501250A5 (https=) | ||
| JP2008517945A5 (https=) | ||
| JP2014516074A5 (https=) | ||
| RU2012116207A (ru) | Производные индола в качестве модуляторов crac | |
| NZ609955A (en) | Sgc stimulators | |
| JP2019537603A5 (https=) | ||
| JP2007501831A5 (https=) | ||
| JP2024528036A5 (https=) | ||
| JP2020532550A5 (https=) | ||
| RU2006129297A (ru) | Производные n-(1,5-дифенил-1н-пиразол-3-ил)сульфонамида со сродством к рецепторам cb1 |