JP2023011769A5 - - Google Patents
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- JP2023011769A5 JP2023011769A5 JP2022172956A JP2022172956A JP2023011769A5 JP 2023011769 A5 JP2023011769 A5 JP 2023011769A5 JP 2022172956 A JP2022172956 A JP 2022172956A JP 2022172956 A JP2022172956 A JP 2022172956A JP 2023011769 A5 JP2023011769 A5 JP 2023011769A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- vitamin
- parts
- parts vitamin
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 4
- 229940088594 vitamin Drugs 0.000 claims 3
- 229930003231 vitamin Natural products 0.000 claims 3
- 235000013343 vitamin Nutrition 0.000 claims 3
- 239000011782 vitamin Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 2
- 229930003451 Vitamin B1 Natural products 0.000 claims 2
- 229930003779 Vitamin B12 Natural products 0.000 claims 2
- 229930003471 Vitamin B2 Natural products 0.000 claims 2
- 229930003537 Vitamin B3 Natural products 0.000 claims 2
- 229930003571 Vitamin B5 Natural products 0.000 claims 2
- 229930003756 Vitamin B7 Natural products 0.000 claims 2
- 229930003761 Vitamin B9 Natural products 0.000 claims 2
- 229930003268 Vitamin C Natural products 0.000 claims 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims 2
- 229960002079 calcium pantothenate Drugs 0.000 claims 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- 229960003512 nicotinic acid Drugs 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 2
- 229960002477 riboflavin Drugs 0.000 claims 2
- 229960003495 thiamine Drugs 0.000 claims 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims 2
- 239000011573 trace mineral Substances 0.000 claims 2
- 235000013619 trace mineral Nutrition 0.000 claims 2
- 235000010374 vitamin B1 Nutrition 0.000 claims 2
- 239000011691 vitamin B1 Substances 0.000 claims 2
- 235000019163 vitamin B12 Nutrition 0.000 claims 2
- 239000011715 vitamin B12 Substances 0.000 claims 2
- 235000019164 vitamin B2 Nutrition 0.000 claims 2
- 239000011716 vitamin B2 Substances 0.000 claims 2
- 235000019160 vitamin B3 Nutrition 0.000 claims 2
- 239000011708 vitamin B3 Substances 0.000 claims 2
- 235000009492 vitamin B5 Nutrition 0.000 claims 2
- 239000011675 vitamin B5 Substances 0.000 claims 2
- 235000019158 vitamin B6 Nutrition 0.000 claims 2
- 239000011726 vitamin B6 Substances 0.000 claims 2
- 235000011912 vitamin B7 Nutrition 0.000 claims 2
- 239000011735 vitamin B7 Substances 0.000 claims 2
- 235000019159 vitamin B9 Nutrition 0.000 claims 2
- 239000011727 vitamin B9 Substances 0.000 claims 2
- 235000019154 vitamin C Nutrition 0.000 claims 2
- 239000011718 vitamin C Substances 0.000 claims 2
- 229940011671 vitamin b6 Drugs 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 229930003448 Vitamin K Natural products 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 229960004050 aminobenzoic acid Drugs 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 229960004874 choline bitartrate Drugs 0.000 claims 1
- QWJSAWXRUVVRLH-UHFFFAOYSA-M choline bitartrate Chemical compound C[N+](C)(C)CCO.OC(=O)C(O)C(O)C([O-])=O QWJSAWXRUVVRLH-UHFFFAOYSA-M 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 229960000367 inositol Drugs 0.000 claims 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 235000019168 vitamin K Nutrition 0.000 claims 1
- 239000011712 vitamin K Substances 0.000 claims 1
- 150000003721 vitamin K derivatives Chemical class 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 229940046010 vitamin k Drugs 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024198677A JP2025024089A (ja) | 2017-03-07 | 2024-11-14 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710131111.X | 2017-03-07 | ||
| CN201710131111.XA CN108567792A (zh) | 2017-03-07 | 2017-03-07 | 一种治疗阿尔茨海默病的复合维生素组合物 |
| PCT/CN2018/077107 WO2018161808A1 (zh) | 2017-03-07 | 2018-02-24 | 维生素组合物在制备用于预防、治疗或延迟阿尔茨海默病的药物中的用途 |
| JP2019548652A JP7169285B2 (ja) | 2017-03-07 | 2018-02-24 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548652A Division JP7169285B2 (ja) | 2017-03-07 | 2018-02-24 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024198677A Division JP2025024089A (ja) | 2017-03-07 | 2024-11-14 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023011769A JP2023011769A (ja) | 2023-01-24 |
| JP2023011769A5 true JP2023011769A5 (https=) | 2023-04-27 |
Family
ID=63448062
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548652A Active JP7169285B2 (ja) | 2017-03-07 | 2018-02-24 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
| JP2022172956A Pending JP2023011769A (ja) | 2017-03-07 | 2022-10-28 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
| JP2024198677A Pending JP2025024089A (ja) | 2017-03-07 | 2024-11-14 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548652A Active JP7169285B2 (ja) | 2017-03-07 | 2018-02-24 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024198677A Pending JP2025024089A (ja) | 2017-03-07 | 2024-11-14 | アルツハイマー病を予防し、治療し、又は遅延させるための薬物の調製におけるビタミン組成物の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11464797B2 (https=) |
| EP (2) | EP4461361A3 (https=) |
| JP (3) | JP7169285B2 (https=) |
| CN (2) | CN108567792A (https=) |
| AU (2) | AU2018229920B2 (https=) |
| BR (1) | BR112019018652A2 (https=) |
| CA (1) | CA3054972A1 (https=) |
| ES (1) | ES2989651T3 (https=) |
| WO (1) | WO2018161808A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114710952A (zh) * | 2019-08-02 | 2022-07-05 | 上海日馨医药科技股份有限公司 | Tpk作为靶点在阿尔茨海默病的应用 |
| KR102275981B1 (ko) * | 2020-03-31 | 2021-07-13 | 고려은단주식회사 | 섬쑥부쟁이 추출물과 비타민 b 복합체의 혼합물을 포함하는 인지기능 개선용 조성물 |
| JPWO2023248374A1 (https=) * | 2022-06-22 | 2023-12-28 | ||
| CN119055674B (zh) * | 2024-11-06 | 2025-02-18 | 中国医学科学院北京协和医院 | 一种可改善认知的组合物及其在阿尔茨海默病防治中的应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5626884A (en) | 1995-08-18 | 1997-05-06 | Lockett; Curtis G. | Treatment of sickle cell disease |
| ATE322275T1 (de) | 1998-06-10 | 2006-04-15 | Albert B Crum | Vorbeugender und therapeutischer nahrungsmittelzusatz zur schaffung/erhaltung einer die gesundheit schützenden darmmikroflora und zur stärkung des immunsystems |
| WO2003082339A1 (en) | 2002-03-22 | 2003-10-09 | Doc's Guide, Inc. | Multivitamin and mineral nutritional supplement |
| JP2004231585A (ja) * | 2002-12-05 | 2004-08-19 | Fancl Corp | 生体内ホモシステインレベル低減用および上昇抑制用組成物 |
| US20080213395A1 (en) | 2004-10-14 | 2008-09-04 | Adventures Plus Pty Ltd | Method for the Treatment of Gastrointestinal and Other Disorders with an Admixture of Vitamins |
| US20110275591A1 (en) * | 2004-12-01 | 2011-11-10 | Concourse Health Sciences Llc | Cocktail for modulation of alzheimer's disease |
| US20060148727A1 (en) * | 2004-12-01 | 2006-07-06 | Curt Hendrix | Folate based composition for neurological and cognitive applications |
| MX2010000224A (es) * | 2007-06-26 | 2010-05-03 | Nutricia Nv | Mejoramiento de la memoria en individuos con mini-examen de estado mental de 24-26. |
| US9763989B2 (en) * | 2007-08-03 | 2017-09-19 | Shaklee Corporation | Nutritional supplement system |
| JP4206428B1 (ja) * | 2008-06-09 | 2009-01-14 | 正樹 今川 | 認知症を処置するための組成物及びその利用 |
| KR20110004691A (ko) * | 2009-07-08 | 2011-01-14 | 대한민국(농촌진흥청장) | 뇌기능 개선효과를 가지는 붉나무 추출물을 포함하는 약학조성물 및 건강식품조성물 |
| WO2011121150A1 (es) * | 2010-03-31 | 2011-10-06 | Vegenat, S.A. | Producto alimenticio enteral u oral especialmente destinado para la nutrición, prevención y mejora de alteraciones neurológicas, neurodegenerativas o trastornos cognitivos |
| US8563609B2 (en) * | 2010-05-13 | 2013-10-22 | Nitromega Corp. | Nitro fatty acids - neuroprotection and/or inhibition of cognitive decline |
| CN104997803B (zh) | 2010-07-22 | 2019-07-09 | 雷文制药有限公司 | 包含使用磁偶极子稳定化溶液的治疗或改善疾病并增强表现的方法和组合物 |
| KR20130015932A (ko) * | 2011-08-05 | 2013-02-14 | 연세대학교 산학협력단 | 저용량의 치아졸리딘다이온을 포함하는 알츠하이머 병 치료용 약학조성물 |
| WO2013066151A1 (en) | 2011-10-31 | 2013-05-10 | N.V. Nutricia | Improving recognition |
| AU2013226627B2 (en) * | 2012-03-02 | 2017-05-25 | N.V. Nutricia | Method for improving functional synaptic connectivity |
| AU2013299656C1 (en) * | 2012-08-07 | 2017-06-22 | Buck Institute For Research On Aging | Multi-component formulation for improving neurological function |
| WO2014026161A1 (en) * | 2012-08-10 | 2014-02-13 | Aquavit Pharmaceuticals, Inc. | Vitamin supplement compositions for injection |
| CN110840895A (zh) | 2013-07-23 | 2020-02-28 | 上海泽生科技开发股份有限公司 | 使用维生素b组合物促进胃肠系统动力的方法 |
| CN104256652A (zh) | 2014-10-08 | 2015-01-07 | 李明刚 | 一种口服复合维生素纳米脂质体 |
| CN104922164B (zh) | 2014-12-12 | 2020-06-02 | 中国医科大学 | 一种治疗阿尔茨海默病的药物复合制剂 |
| CN106265696A (zh) * | 2015-06-12 | 2017-01-04 | 上海泽生科技开发有限公司 | 使用复合维生素b、c组合物促进胃肠系统动力的方法 |
| CN104856048A (zh) | 2015-06-18 | 2015-08-26 | 安徽医联大成医药科技有限公司 | 一种促进肠胃蠕动的食品配方及其制备方法 |
| CN108079008A (zh) * | 2016-11-23 | 2018-05-29 | 上海泽生科技开发股份有限公司 | 促进胃肠系统动力的复合维生素组合物 |
-
2017
- 2017-03-07 CN CN201710131111.XA patent/CN108567792A/zh active Pending
-
2018
- 2018-02-24 AU AU2018229920A patent/AU2018229920B2/en active Active
- 2018-02-24 EP EP24189913.7A patent/EP4461361A3/en not_active Withdrawn
- 2018-02-24 CA CA3054972A patent/CA3054972A1/en not_active Abandoned
- 2018-02-24 JP JP2019548652A patent/JP7169285B2/ja active Active
- 2018-02-24 ES ES18763903T patent/ES2989651T3/es active Active
- 2018-02-24 WO PCT/CN2018/077107 patent/WO2018161808A1/zh not_active Ceased
- 2018-02-24 US US16/491,560 patent/US11464797B2/en active Active
- 2018-02-24 CN CN201880015481.XA patent/CN110520135A/zh active Pending
- 2018-02-24 EP EP18763903.4A patent/EP3593805B1/en active Active
- 2018-02-24 BR BR112019018652A patent/BR112019018652A2/pt not_active Application Discontinuation
-
2022
- 2022-09-15 US US17/945,684 patent/US20230248756A1/en not_active Abandoned
- 2022-10-28 JP JP2022172956A patent/JP2023011769A/ja active Pending
-
2024
- 2024-04-24 AU AU2024202678A patent/AU2024202678A1/en active Pending
- 2024-11-14 JP JP2024198677A patent/JP2025024089A/ja active Pending
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