JP2022554282A5 - - Google Patents

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Publication number
JP2022554282A5
JP2022554282A5 JP2022525306A JP2022525306A JP2022554282A5 JP 2022554282 A5 JP2022554282 A5 JP 2022554282A5 JP 2022525306 A JP2022525306 A JP 2022525306A JP 2022525306 A JP2022525306 A JP 2022525306A JP 2022554282 A5 JP2022554282 A5 JP 2022554282A5
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JP
Japan
Prior art keywords
sodium chloride
buffer contains
cation exchange
washing
acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022525306A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022554282A (ja
JP7760500B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/058772 external-priority patent/WO2021091932A1/en
Publication of JP2022554282A publication Critical patent/JP2022554282A/ja
Publication of JP2022554282A5 publication Critical patent/JP2022554282A5/ja
Priority to JP2025172458A priority Critical patent/JP2026012744A/ja
Application granted granted Critical
Publication of JP7760500B2 publication Critical patent/JP7760500B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2022525306A 2019-11-07 2020-11-04 生成物関連不純物を除去するためのカチオン交換クロマトグラフィー中の高塩分負荷コンディショニング Active JP7760500B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025172458A JP2026012744A (ja) 2019-11-07 2025-10-14 生成物関連不純物を除去するためのカチオン交換クロマトグラフィー中の高塩分負荷コンディショニング

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962931863P 2019-11-07 2019-11-07
US62/931,863 2019-11-07
PCT/US2020/058772 WO2021091932A1 (en) 2019-11-07 2020-11-04 High salt load conditioning during cation exchange chromatography to remove product-realated impurities

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025172458A Division JP2026012744A (ja) 2019-11-07 2025-10-14 生成物関連不純物を除去するためのカチオン交換クロマトグラフィー中の高塩分負荷コンディショニング

Publications (3)

Publication Number Publication Date
JP2022554282A JP2022554282A (ja) 2022-12-28
JP2022554282A5 true JP2022554282A5 (https=) 2023-08-15
JP7760500B2 JP7760500B2 (ja) 2025-10-27

Family

ID=73598211

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022525306A Active JP7760500B2 (ja) 2019-11-07 2020-11-04 生成物関連不純物を除去するためのカチオン交換クロマトグラフィー中の高塩分負荷コンディショニング
JP2025172458A Pending JP2026012744A (ja) 2019-11-07 2025-10-14 生成物関連不純物を除去するためのカチオン交換クロマトグラフィー中の高塩分負荷コンディショニング

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025172458A Pending JP2026012744A (ja) 2019-11-07 2025-10-14 生成物関連不純物を除去するためのカチオン交換クロマトグラフィー中の高塩分負荷コンディショニング

Country Status (13)

Country Link
US (1) US20220372070A1 (https=)
EP (1) EP4055041A1 (https=)
JP (2) JP7760500B2 (https=)
KR (1) KR20220092969A (https=)
CN (1) CN114746441A (https=)
AU (1) AU2020380256A1 (https=)
BR (1) BR112022008649A2 (https=)
CA (1) CA3160143A1 (https=)
CL (3) CL2022001168A1 (https=)
IL (1) IL292594A (https=)
MX (1) MX2022005593A (https=)
WO (1) WO2021091932A1 (https=)
ZA (1) ZA202205010B (https=)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019970A2 (en) * 1999-09-15 2001-03-22 Eli Lilly And Company Chymotrypsin-free trypsin
CA2645739A1 (en) * 2006-03-20 2007-09-27 Medarex, Inc. Protein purification
EP2009101B1 (en) * 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
CN104628846B (zh) * 2013-11-06 2019-12-06 三生国健药业（上海）股份有限公司 重组蛋白质的纯化方法
US9611325B2 (en) * 2014-07-21 2017-04-04 Wuhan Yzy Biopharma Co., Ltd. Construction and application of bispecific antibody HER2xCD3
EP3204415B1 (en) * 2014-10-09 2020-06-17 EngMab Sàrl Bispecific antibodies against cd3epsilon and ror1
JP6699085B2 (ja) * 2015-03-25 2020-05-27 東ソー株式会社 Ｆｃ結合性タンパク質の精製方法
CN119161488A (zh) * 2017-11-01 2024-12-20 中外制药株式会社 具有降低的生物活性的抗体变体和同种型
CN110305217B (zh) * 2018-03-27 2022-03-29 广州爱思迈生物医药科技有限公司 双特异性抗体及其应用

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