BR112022008649A2 - Condicionamento de carga com alto teor de sal durante cromatografia de troca catiônica para remover impurezas relacionadas ao produto - Google Patents

Condicionamento de carga com alto teor de sal durante cromatografia de troca catiônica para remover impurezas relacionadas ao produto

Info

Publication number
BR112022008649A2
BR112022008649A2 BR112022008649A BR112022008649A BR112022008649A2 BR 112022008649 A2 BR112022008649 A2 BR 112022008649A2 BR 112022008649 A BR112022008649 A BR 112022008649A BR 112022008649 A BR112022008649 A BR 112022008649A BR 112022008649 A2 BR112022008649 A2 BR 112022008649A2
Authority
BR
Brazil
Prior art keywords
cation exchange
exchange chromatography
high salt
related impurities
during cation
Prior art date
Application number
BR112022008649A
Other languages
English (en)
Portuguese (pt)
Inventor
Diaz Luis
Gomez Natalia
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112022008649A2 publication Critical patent/BR112022008649A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112022008649A 2019-11-07 2020-11-04 Condicionamento de carga com alto teor de sal durante cromatografia de troca catiônica para remover impurezas relacionadas ao produto BR112022008649A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962931863P 2019-11-07 2019-11-07
PCT/US2020/058772 WO2021091932A1 (en) 2019-11-07 2020-11-04 High salt load conditioning during cation exchange chromatography to remove product-realated impurities

Publications (1)

Publication Number Publication Date
BR112022008649A2 true BR112022008649A2 (pt) 2022-07-19

Family

ID=73598211

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022008649A BR112022008649A2 (pt) 2019-11-07 2020-11-04 Condicionamento de carga com alto teor de sal durante cromatografia de troca catiônica para remover impurezas relacionadas ao produto

Country Status (13)

Country Link
US (1) US20220372070A1 (https=)
EP (1) EP4055041A1 (https=)
JP (2) JP7760500B2 (https=)
KR (1) KR20220092969A (https=)
CN (1) CN114746441A (https=)
AU (1) AU2020380256A1 (https=)
BR (1) BR112022008649A2 (https=)
CA (1) CA3160143A1 (https=)
CL (3) CL2022001168A1 (https=)
IL (1) IL292594A (https=)
MX (1) MX2022005593A (https=)
WO (1) WO2021091932A1 (https=)
ZA (1) ZA202205010B (https=)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019970A2 (en) * 1999-09-15 2001-03-22 Eli Lilly And Company Chymotrypsin-free trypsin
CA2645739A1 (en) * 2006-03-20 2007-09-27 Medarex, Inc. Protein purification
EP2009101B1 (en) * 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
CN104628846B (zh) * 2013-11-06 2019-12-06 三生国健药业（上海）股份有限公司 重组蛋白质的纯化方法
US9611325B2 (en) * 2014-07-21 2017-04-04 Wuhan Yzy Biopharma Co., Ltd. Construction and application of bispecific antibody HER2xCD3
EP3204415B1 (en) * 2014-10-09 2020-06-17 EngMab Sàrl Bispecific antibodies against cd3epsilon and ror1
JP6699085B2 (ja) * 2015-03-25 2020-05-27 東ソー株式会社 Ｆｃ結合性タンパク質の精製方法
CN119161488A (zh) * 2017-11-01 2024-12-20 中外制药株式会社 具有降低的生物活性的抗体变体和同种型
CN110305217B (zh) * 2018-03-27 2022-03-29 广州爱思迈生物医药科技有限公司 双特异性抗体及其应用

Also Published As

Publication number Publication date
CL2022001168A1 (es) 2023-01-27
EP4055041A1 (en) 2022-09-14
MX2022005593A (es) 2022-06-09
WO2021091932A1 (en) 2021-05-14
CL2024001788A1 (es) 2024-09-27
JP2022554282A (ja) 2022-12-28
AU2020380256A1 (en) 2022-06-09
CL2025003712A1 (es) 2026-01-09
IL292594A (en) 2022-07-01
KR20220092969A (ko) 2022-07-04
JP7760500B2 (ja) 2025-10-27
CN114746441A (zh) 2022-07-12
CA3160143A1 (en) 2021-05-14
US20220372070A1 (en) 2022-11-24
ZA202205010B (en) 2023-01-25
JP2026012744A (ja) 2026-01-27

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: application reinstated [chapter 4.3 patent gazette]