BR112022008782A2 - Lavagens com alto teor de sal durante cromatografia de troca catiônica para remover impurezas relacionadas ao produto - Google Patents
Lavagens com alto teor de sal durante cromatografia de troca catiônica para remover impurezas relacionadas ao produtoInfo
- Publication number
- BR112022008782A2 BR112022008782A2 BR112022008782A BR112022008782A BR112022008782A2 BR 112022008782 A2 BR112022008782 A2 BR 112022008782A2 BR 112022008782 A BR112022008782 A BR 112022008782A BR 112022008782 A BR112022008782 A BR 112022008782A BR 112022008782 A2 BR112022008782 A2 BR 112022008782A2
- Authority
- BR
- Brazil
- Prior art keywords
- cation exchange
- exchange chromatography
- high salt
- washes
- salt content
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/16—Diafiltration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Water Supply & Treatment (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LAVAGENS COM ALTO TEOR DE SAL DURANTE CROMATOGRAFIA DE TROCA CATIÔNICA PARA REMOVER IMPUREZAS RELACIONADAS AO PRODUTO. A invenção se refere a métodos para remoção de impurezas relacionadas ao produto de ponto isoelétrico baixo durante operações de purificação de troca catiônica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962931874P | 2019-11-07 | 2019-11-07 | |
PCT/US2020/058774 WO2021091933A1 (en) | 2019-11-07 | 2020-11-04 | High salt washes during cation exchange chromatography to remove product-realated impurities |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022008782A2 true BR112022008782A2 (pt) | 2022-07-26 |
Family
ID=73598212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022008782A BR112022008782A2 (pt) | 2019-11-07 | 2020-11-04 | Lavagens com alto teor de sal durante cromatografia de troca catiônica para remover impurezas relacionadas ao produto |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220372071A1 (pt) |
EP (1) | EP4055042A1 (pt) |
JP (1) | JP2022554283A (pt) |
KR (1) | KR20220092958A (pt) |
CN (1) | CN114651007A (pt) |
AR (1) | AR120398A1 (pt) |
AU (1) | AU2020377919A1 (pt) |
BR (1) | BR112022008782A2 (pt) |
CA (1) | CA3160208A1 (pt) |
CL (1) | CL2022001169A1 (pt) |
IL (1) | IL292602A (pt) |
MX (1) | MX2022005594A (pt) |
TW (1) | TW202132323A (pt) |
WO (1) | WO2021091933A1 (pt) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120238730A1 (en) * | 2011-03-15 | 2012-09-20 | Abbott Laboratories | Integrated approach to the isolation and purification of antibodies |
US20170183376A1 (en) * | 2014-06-24 | 2017-06-29 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
JP6699085B2 (ja) * | 2015-03-25 | 2020-05-27 | 東ソー株式会社 | Fc結合性タンパク質の精製方法 |
MX2018015173A (es) * | 2016-06-17 | 2019-07-04 | Genentech Inc | Purificacion de anticuerpos multiespecificos. |
CN110305217B (zh) * | 2018-03-27 | 2022-03-29 | 广州爱思迈生物医药科技有限公司 | 双特异性抗体及其应用 |
-
2020
- 2020-11-04 IL IL292602A patent/IL292602A/en unknown
- 2020-11-04 AU AU2020377919A patent/AU2020377919A1/en active Pending
- 2020-11-04 CN CN202080077533.3A patent/CN114651007A/zh active Pending
- 2020-11-04 BR BR112022008782A patent/BR112022008782A2/pt unknown
- 2020-11-04 CA CA3160208A patent/CA3160208A1/en active Pending
- 2020-11-04 WO PCT/US2020/058774 patent/WO2021091933A1/en active Application Filing
- 2020-11-04 US US17/773,892 patent/US20220372071A1/en active Pending
- 2020-11-04 KR KR1020227018752A patent/KR20220092958A/ko unknown
- 2020-11-04 JP JP2022525320A patent/JP2022554283A/ja active Pending
- 2020-11-04 MX MX2022005594A patent/MX2022005594A/es unknown
- 2020-11-04 EP EP20812495.8A patent/EP4055042A1/en active Pending
- 2020-11-05 AR ARP200103071A patent/AR120398A1/es unknown
- 2020-11-06 TW TW109138883A patent/TW202132323A/zh unknown
-
2022
- 2022-05-04 CL CL2022001169A patent/CL2022001169A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN114651007A (zh) | 2022-06-21 |
IL292602A (en) | 2022-07-01 |
CA3160208A1 (en) | 2021-05-14 |
CL2022001169A1 (es) | 2023-01-27 |
WO2021091933A1 (en) | 2021-05-14 |
KR20220092958A (ko) | 2022-07-04 |
US20220372071A1 (en) | 2022-11-24 |
TW202132323A (zh) | 2021-09-01 |
AU2020377919A1 (en) | 2022-06-16 |
EP4055042A1 (en) | 2022-09-14 |
MX2022005594A (es) | 2022-06-09 |
AR120398A1 (es) | 2022-02-09 |
JP2022554283A (ja) | 2022-12-28 |
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