JP2022549852A - ケトレダクターゼポリペプチドおよびポリヌクレオチド - Google Patents

ケトレダクターゼポリペプチドおよびポリヌクレオチド Download PDF

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Publication number
JP2022549852A
JP2022549852A JP2022518961A JP2022518961A JP2022549852A JP 2022549852 A JP2022549852 A JP 2022549852A JP 2022518961 A JP2022518961 A JP 2022518961A JP 2022518961 A JP2022518961 A JP 2022518961A JP 2022549852 A JP2022549852 A JP 2022549852A
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Japan
Prior art keywords
seq
engineered
variant
engineered ketoreductase
ketoreductase
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Ceased
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JP2022518961A
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Japanese (ja)
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JP2022549852A5 (enExample
Inventor
ジャック リャン，
ナンディタ スブラマニアン，
シャーリーン チン，
デイビッド ウィリアム ホーマン，
ケイティ ウォーレン，
マシュー ブレイク ジョーンズ，
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コデクシス， インコーポレイテッド
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Publication of JP2022549852A publication Critical patent/JP2022549852A/ja
Publication of JP2022549852A5 publication Critical patent/JP2022549852A5/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022518961A 2019-09-26 2020-09-24 ケトレダクターゼポリペプチドおよびポリヌクレオチド Ceased JP2022549852A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962906268P 2019-09-26 2019-09-26
US62/906,268 2019-09-26
PCT/US2020/052396 WO2021061915A2 (en) 2019-09-26 2020-09-24 Ketoreductase polypeptides and polynucleotides

Publications (2)

Publication Number Publication Date
JP2022549852A true JP2022549852A (ja) 2022-11-29
JP2022549852A5 JP2022549852A5 (enExample) 2023-09-15

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JP2022518961A Ceased JP2022549852A (ja) 2019-09-26 2020-09-24 ケトレダクターゼポリペプチドおよびポリヌクレオチド

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Country Link
US (1) US20230287360A1 (enExample)
EP (1) EP4034644A4 (enExample)
JP (1) JP2022549852A (enExample)
KR (1) KR20220066952A (enExample)
CN (1) CN114555795B (enExample)
CA (1) CA3155659A1 (enExample)
CL (1) CL2022000671A1 (enExample)
CO (1) CO2022005038A2 (enExample)
IL (1) IL291552A (enExample)
MX (1) MX2022003684A (enExample)
WO (1) WO2021061915A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3114415A1 (en) 2018-09-26 2020-04-02 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
US11591625B2 (en) 2018-09-26 2023-02-28 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100151534A1 (en) * 2008-08-27 2010-06-17 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
JP2010539948A (ja) * 2007-09-28 2010-12-24 コデクシス， インコーポレイテッド ケトレダクターゼポリペプチドおよびその使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101586503B1 (ko) * 2007-09-13 2016-01-18 코덱시스, 인코포레이티드 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드
US20110117252A1 (en) * 2009-11-13 2011-05-19 Kalamazoo Holdings, Inc. Process for the preparation of tetrahydroisohumulone compositions
HUE038800T2 (hu) * 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
CN104342412B (zh) * 2013-08-09 2018-12-21 南京朗恩生物科技有限公司 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体
CA3114415A1 (en) * 2018-09-26 2020-04-02 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
CA3114400A1 (en) * 2018-09-26 2020-04-02 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
US11591625B2 (en) * 2018-09-26 2023-02-28 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010539948A (ja) * 2007-09-28 2010-12-24 コデクシス， インコーポレイテッド ケトレダクターゼポリペプチドおよびその使用
US20100151534A1 (en) * 2008-08-27 2010-06-17 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine

Also Published As

Publication number Publication date
MX2022003684A (es) 2022-04-25
CO2022005038A2 (es) 2022-05-31
CN114555795B (zh) 2025-05-27
WO2021061915A3 (en) 2021-05-06
CN114555795A (zh) 2022-05-27
US20230287360A1 (en) 2023-09-14
CA3155659A1 (en) 2021-04-01
EP4034644A4 (en) 2023-11-01
KR20220066952A (ko) 2022-05-24
WO2021061915A2 (en) 2021-04-01
IL291552A (en) 2022-05-01
CL2022000671A1 (es) 2022-11-11
EP4034644A2 (en) 2022-08-03

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