CL2022000671A1 - Polipéptidos y polinucleótidos cetorreductasa - Google Patents

Polipéptidos y polinucleótidos cetorreductasa

Info

Publication number
CL2022000671A1
CL2022000671A1 CL2022000671A CL2022000671A CL2022000671A1 CL 2022000671 A1 CL2022000671 A1 CL 2022000671A1 CL 2022000671 A CL2022000671 A CL 2022000671A CL 2022000671 A CL2022000671 A CL 2022000671A CL 2022000671 A1 CL2022000671 A1 CL 2022000671A1
Authority
CL
Chile
Prior art keywords
modified
ketoreductase
enzymes
polynucleotides
ketoreductase polypeptides
Prior art date
Application number
CL2022000671A
Other languages
English (en)
Inventor
Jack Liang
Nandhitha Subramanian
Charlene Ching
David William Homan
Katie Whalen
Matthew Jones
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of CL2022000671A1 publication Critical patent/CL2022000671A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención provee enzimas cetorreductasa modificadas que tienen propiedades mejoradas en comparación con una enzima cetorreductasa salvaje de origen natural, así como polinucleótidos que codifican las enzimas cetorreductasa modificadas, células huésped capaces de expresar las enzimas cetorreductasa modificadas y métodos para usar las enzimas cetorreductasa modificadas para sintetizar un alcohol quiral. La presente invención también provee métodos para usar las enzimas modificadas.
CL2022000671A 2019-09-26 2022-03-18 Polipéptidos y polinucleótidos cetorreductasa CL2022000671A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962906268P 2019-09-26 2019-09-26

Publications (1)

Publication Number Publication Date
CL2022000671A1 true CL2022000671A1 (es) 2022-11-11

Family

ID=75166136

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022000671A CL2022000671A1 (es) 2019-09-26 2022-03-18 Polipéptidos y polinucleótidos cetorreductasa

Country Status (11)

Country Link
US (1) US20230287360A1 (es)
EP (1) EP4034644A4 (es)
JP (1) JP2022549852A (es)
KR (1) KR20220066952A (es)
CN (1) CN114555795A (es)
CA (1) CA3155659A1 (es)
CL (1) CL2022000671A1 (es)
CO (1) CO2022005038A2 (es)
IL (1) IL291552A (es)
MX (1) MX2022003684A (es)
WO (1) WO2021061915A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11591625B2 (en) 2018-09-26 2023-02-28 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
US20200095619A1 (en) 2018-09-26 2020-03-26 Kalamazoo Holdings, Inc . New enzymatic process for production of modified hop products

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5973131B2 (ja) * 2007-09-13 2016-08-23 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
KR20100061571A (ko) * 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 케토리덕타제 폴리펩티드 및 이의 용도
HUE026181T2 (en) * 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
WO2011059486A1 (en) * 2009-11-13 2011-05-19 Kalamazoo Holdings, Inc. Process for the preparation of tetrahydroisohumulone compositions
CN104342412B (zh) * 2013-08-09 2018-12-21 南京朗恩生物科技有限公司 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体
WO2020069100A1 (en) * 2018-09-26 2020-04-02 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
US20200095619A1 (en) * 2018-09-26 2020-03-26 Kalamazoo Holdings, Inc . New enzymatic process for production of modified hop products

Also Published As

Publication number Publication date
CA3155659A1 (en) 2021-04-01
WO2021061915A2 (en) 2021-04-01
MX2022003684A (es) 2022-04-25
EP4034644A4 (en) 2023-11-01
KR20220066952A (ko) 2022-05-24
CN114555795A (zh) 2022-05-27
JP2022549852A (ja) 2022-11-29
EP4034644A2 (en) 2022-08-03
IL291552A (en) 2022-05-01
US20230287360A1 (en) 2023-09-14
WO2021061915A3 (en) 2021-05-06
CO2022005038A2 (es) 2022-05-31

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