CN114555795B - 酮还原酶多肽及多核苷酸 - Google Patents

酮还原酶多肽及多核苷酸 Download PDF

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Publication number
CN114555795B
CN114555795B CN202080067803.2A CN202080067803A CN114555795B CN 114555795 B CN114555795 B CN 114555795B CN 202080067803 A CN202080067803 A CN 202080067803A CN 114555795 B CN114555795 B CN 114555795B
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Chinese (zh)
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CN114555795A (zh
Inventor
杰克·梁
南希塔·苏布兰马尼安
沙琳·奇恩
大卫·威廉·霍曼
卡蒂·惠伦
马修·布莱克·琼斯
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Codexis Inc
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Codexis Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080067803.2A 2019-09-26 2020-09-24 酮还原酶多肽及多核苷酸 Active CN114555795B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962906268P 2019-09-26 2019-09-26
US62/906,268 2019-09-26
PCT/US2020/052396 WO2021061915A2 (en) 2019-09-26 2020-09-24 Ketoreductase polypeptides and polynucleotides

Publications (2)

Publication Number Publication Date
CN114555795A CN114555795A (zh) 2022-05-27
CN114555795B true CN114555795B (zh) 2025-05-27

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CN202080067803.2A Active CN114555795B (zh) 2019-09-26 2020-09-24 酮还原酶多肽及多核苷酸

Country Status (11)

Country Link
US (1) US20230287360A1 (enExample)
EP (1) EP4034644A4 (enExample)
JP (1) JP2022549852A (enExample)
KR (1) KR20220066952A (enExample)
CN (1) CN114555795B (enExample)
CA (1) CA3155659A1 (enExample)
CL (1) CL2022000671A1 (enExample)
CO (1) CO2022005038A2 (enExample)
IL (1) IL291552A (enExample)
MX (1) MX2022003684A (enExample)
WO (1) WO2021061915A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3114415A1 (en) 2018-09-26 2020-04-02 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
US11591625B2 (en) 2018-09-26 2023-02-28 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010025238A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101586503B1 (ko) * 2007-09-13 2016-01-18 코덱시스, 인코포레이티드 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드
CN101889081B (zh) * 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
US20110117252A1 (en) * 2009-11-13 2011-05-19 Kalamazoo Holdings, Inc. Process for the preparation of tetrahydroisohumulone compositions
HUE038800T2 (hu) * 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
CN104342412B (zh) * 2013-08-09 2018-12-21 南京朗恩生物科技有限公司 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体
CA3114415A1 (en) * 2018-09-26 2020-04-02 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
CA3114400A1 (en) * 2018-09-26 2020-04-02 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
US11591625B2 (en) * 2018-09-26 2023-02-28 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010025238A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine

Also Published As

Publication number Publication date
MX2022003684A (es) 2022-04-25
CO2022005038A2 (es) 2022-05-31
WO2021061915A3 (en) 2021-05-06
CN114555795A (zh) 2022-05-27
US20230287360A1 (en) 2023-09-14
CA3155659A1 (en) 2021-04-01
EP4034644A4 (en) 2023-11-01
KR20220066952A (ko) 2022-05-24
WO2021061915A2 (en) 2021-04-01
IL291552A (en) 2022-05-01
CL2022000671A1 (es) 2022-11-11
EP4034644A2 (en) 2022-08-03
JP2022549852A (ja) 2022-11-29

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