JP2022548859A - 認知機能の改善における使用および物質依存症に対する使用のためのチアゾールおよびジフェニル置換スルホキシド - Google Patents

認知機能の改善における使用および物質依存症に対する使用のためのチアゾールおよびジフェニル置換スルホキシド Download PDF

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JP2022548859A
JP2022548859A JP2022516164A JP2022516164A JP2022548859A JP 2022548859 A JP2022548859 A JP 2022548859A JP 2022516164 A JP2022516164 A JP 2022516164A JP 2022516164 A JP2022516164 A JP 2022516164A JP 2022548859 A JP2022548859 A JP 2022548859A
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Prior art keywords
methyl
thiazole
phenyl
sulfinyl
bromophenyl
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JP2022516164A
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Japanese (ja)
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JP2022548859A5 (https=
Inventor
ルベック，ゲルト
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Red Bull GmbH
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Red Bull GmbH
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Publication of JP2022548859A5 publication Critical patent/JP2022548859A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022516164A 2019-09-13 2020-09-10 認知機能の改善における使用および物質依存症に対する使用のためのチアゾールおよびジフェニル置換スルホキシド Pending JP2022548859A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19197359.3 2019-09-13
EP19197359.3A EP3792252A1 (en) 2019-09-13 2019-09-13 Thiazole and diphenyl substituted sulfoxides for use in improving cognition functions and against addictions to substances.
PCT/EP2020/075338 WO2021048284A1 (en) 2019-09-13 2020-09-10 Thiazole and diphenyl substituted sulfoxides for use in improving cognition functions and against addictions to substances

Publications (2)

Publication Number Publication Date
JP2022548859A true JP2022548859A (ja) 2022-11-22
JP2022548859A5 JP2022548859A5 (https=) 2023-10-02

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JP2022516164A Pending JP2022548859A (ja) 2019-09-13 2020-09-10 認知機能の改善における使用および物質依存症に対する使用のためのチアゾールおよびジフェニル置換スルホキシド

Country Status (7)

Country Link
US (1) US12612374B2 (https=)
EP (1) EP3792252A1 (https=)
JP (1) JP2022548859A (https=)
KR (1) KR20220062376A (https=)
CN (1) CN114401948A (https=)
CA (1) CA3154003A1 (https=)
WO (1) WO2021048284A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114917350B (zh) * 2022-06-21 2023-06-13 重庆医科大学附属第二医院 Cftr增强剂在注意缺陷与多动障碍中的应用及产品

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016023997A1 (en) * 2014-08-13 2016-02-18 Red Bull Gmbh Heterocyclic compounds with working memory enhancing activity
CN107522693B (zh) * 2017-08-15 2018-12-04 北京豪思生物科技有限公司 一种6-元芳香环或杂芳香环化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670358B2 (en) 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
JP4394451B2 (ja) 2002-01-04 2010-01-06 ニューロサーチ、アクティーゼルスカブ カリウムチャネルモジュレーター
EP1472214A2 (en) 2002-02-08 2004-11-03 SmithKline Beecham Corporation Compounds for inhibiting insulin secretion and methods related thereto
EP2292213A1 (en) 2004-02-06 2011-03-09 Cephalon, Inc. Compositions comprising a polymorphic form of armodafinil
US7314875B2 (en) 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
NZ619408A (en) * 2009-03-11 2015-08-28 Omeros Corp Compositions and methods for prophylaxis and treatment of addictions
EP3553053A1 (en) * 2018-04-12 2019-10-16 Red Bull GmbH (s)-enantiomeric form of a heterocyclic compound having motivation improving and/or reference memory enhancing activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016023997A1 (en) * 2014-08-13 2016-02-18 Red Bull Gmbh Heterocyclic compounds with working memory enhancing activity
CN107522693B (zh) * 2017-08-15 2018-12-04 北京豪思生物科技有限公司 一种6-元芳香环或杂芳香环化合物及其制备方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
山中 宏 他: "光学活性体のプレパレーション・生理活性・利用", 季刊 化学総説 光学異性体の分離, JPN3011000610, 10 June 1999 (1999-06-10), pages 8 - 9, ISSN: 0005519759 *

Also Published As

Publication number Publication date
US12612374B2 (en) 2026-04-28
CN114401948A (zh) 2022-04-26
EP3792252A1 (en) 2021-03-17
US20220324821A1 (en) 2022-10-13
CA3154003A1 (en) 2021-03-18
WO2021048284A1 (en) 2021-03-18
KR20220062376A (ko) 2022-05-16

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