JP2022547023A - 感染の宿主ｒｎａバイオマーカーの迅速な早期検出及びヒトにおけるｃｏｖｉｄ－１９コロナウイルス感染の早期同定のためのシステム、方法、及び組成物。 - Google Patents

感染の宿主ｒｎａバイオマーカーの迅速な早期検出及びヒトにおけるｃｏｖｉｄ－１９コロナウイルス感染の早期同定のためのシステム、方法、及び組成物。 Download PDF

Info

Publication number
JP2022547023A
JP2022547023A JP2022514151A JP2022514151A JP2022547023A JP 2022547023 A JP2022547023 A JP 2022547023A JP 2022514151 A JP2022514151 A JP 2022514151A JP 2022514151 A JP2022514151 A JP 2022514151A JP 2022547023 A JP2022547023 A JP 2022547023A
Authority
JP
Japan
Prior art keywords
biomarkers
host
infection
derived
lateral flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022514151A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022547023A5 (https=
Inventor
ソーヤー，サラ，エル．
メイヤーソン，ニコラス，アール．
ペイジ，カミール，エル．
ヤン，チィン
ダウエル，ロビン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sawyer sara l
Original Assignee
Sawyer sara l
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sawyer sara l filed Critical Sawyer sara l
Publication of JP2022547023A publication Critical patent/JP2022547023A/ja
Publication of JP2022547023A5 publication Critical patent/JP2022547023A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1877—Means for temperature control using chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/301—Hairpin oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10—Detection mode being characterised by the assay principle
    • C12Q2565/102—Multiple non-interacting labels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022514151A 2019-09-03 2020-09-03 感染の宿主ｒｎａバイオマーカーの迅速な早期検出及びヒトにおけるｃｏｖｉｄ－１９コロナウイルス感染の早期同定のためのシステム、方法、及び組成物。 Pending JP2022547023A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962895387P 2019-09-03 2019-09-03
US62/895,387 2019-09-03
US201962934754P 2019-11-13 2019-11-13
US62/934,754 2019-11-13
US202063006570P 2020-04-07 2020-04-07
US63/006,570 2020-04-07
PCT/US2020/049290 WO2021046278A1 (en) 2019-09-03 2020-09-03 Systems, methods, and compositions for the rapid early-detection of host rna biomarkers of infection and early identification of covid-19 coronavirus infection in humans

Publications (2)

Publication Number Publication Date
JP2022547023A true JP2022547023A (ja) 2022-11-10
JP2022547023A5 JP2022547023A5 (https=) 2023-10-20

Family

ID=74853432

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022514151A Pending JP2022547023A (ja) 2019-09-03 2020-09-03 感染の宿主ｒｎａバイオマーカーの迅速な早期検出及びヒトにおけるｃｏｖｉｄ－１９コロナウイルス感染の早期同定のためのシステム、方法、及び組成物。

Country Status (9)

Country Link
US (1) US20220259682A1 (https=)
EP (1) EP4025345A4 (https=)
JP (1) JP2022547023A (https=)
KR (1) KR20220054401A (https=)
CN (1) CN116171198A (https=)
AU (1) AU2020343336A1 (https=)
CA (1) CA3153071A1 (https=)
IL (1) IL291080A (https=)
WO (1) WO2021046278A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113215314B (zh) * 2021-05-10 2021-12-03 江苏海洋大学 一种利用L/RPA快速检测SARS-CoV-2的探针及引物组、试剂盒、检测方法
WO2022240887A1 (en) * 2021-05-10 2022-11-17 Icahn School Of Medicine At Mount Sinai Methods for detecting and staging cellular viral immune responses
US11513097B1 (en) 2021-05-21 2022-11-29 PERSOWN, Inc. Methods of obtaining and using electrochemical diagnostic results
JP2024520052A (ja) * 2021-05-28 2024-05-21 スリーエム イノベイティブ プロパティズ カンパニー サンプル収集デバイス及びシステム
US20230109581A1 (en) * 2021-10-01 2023-04-06 Detect, Inc. Color reading for diagnostic tests
KR102918977B1 (ko) 2023-01-31 2026-01-28 경상국립대학교산학협력단 기계학습 모델 학습 방법, 기계학습 기반 covid-19 전조증상 감지 방법 및 이를 수행하는 프로그램이 기록된 컴퓨터 판독이 가능한 기록매체
CN118645160B (zh) * 2024-08-12 2024-10-29 中国人民解放军空军军医大学 标志物的检测试剂在制备新冠病情风险评估产品中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170253916A1 (en) * 2016-03-04 2017-09-07 University Of Notre Dame Du Lac Exosomal biomarkers diagnostic of tuberculosis
KR20180041085A (ko) * 2016-10-13 2018-04-23 연세대학교 산학협력단 X-링크된 부신백질이영양증 예방 또는 치료용 물질 스크리닝 방법
JP2022544702A (ja) * 2019-08-19 2022-10-20 ストーク セラピューティクス，インク． スプライシングおよびタンパク質発現を調節するための組成物および方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030000B2 (en) * 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
WO2005001113A2 (en) * 2003-06-27 2005-01-06 Thomas Jefferson University Methods for detecting nucleic acid variations
EP1815021A2 (en) * 2004-11-03 2007-08-08 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
CN101218355A (zh) * 2004-11-05 2008-07-09 海军秘书处代表的美国政府 利用宿主血液生物基因表达标记诊断和预后判断感染性疾病的临床表型及其它生理状态
CN101374964B (zh) * 2005-12-09 2013-07-17 贝勒研究院 外周血液白细胞转录模式的模块水平分析
EP2192197A1 (en) * 2008-11-27 2010-06-02 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Predicting clinical response to treatment with a soluble tnf-antagonist or tnf, or a tnf receptor agonist
IN2010MU00471A (https=) * 2010-02-22 2011-01-07 Shivkumar Dindayalsingh Chauhan
WO2015048098A1 (en) * 2013-09-24 2015-04-02 Washington University Diagnostic methods for infectious disease using endogenous gene expression
WO2017058827A1 (en) * 2015-09-29 2017-04-06 Essenlix Corp. Method of detecting an analyte in a sample
WO2017180909A1 (en) * 2016-04-13 2017-10-19 Nextgen Jane, Inc. Sample collection and preservation devices, systems and methods
AU2017315328A1 (en) * 2016-08-24 2019-03-21 Immunexpress Pty Ltd Systemic inflammatory and pathogen biomarkers and uses therefor
US10329630B2 (en) * 2016-12-09 2019-06-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for detection and discrimination of emerging influenza virus subtypes
FI3607065T3 (fi) * 2017-04-06 2023-06-16 Qing Wang Menetelmä ja tarvikesarja nukleiinihappokirjaston rakentamista varten
EP3673082B1 (en) * 2017-08-25 2026-01-28 Zoetis Services LLC A nucleic acid probe, a method of immobilizing the nucleic acid to a solid support using uv light
CN111630162A (zh) * 2017-10-04 2020-09-04 博德研究所 基于crispr效应系统的诊断

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170253916A1 (en) * 2016-03-04 2017-09-07 University Of Notre Dame Du Lac Exosomal biomarkers diagnostic of tuberculosis
KR20180041085A (ko) * 2016-10-13 2018-04-23 연세대학교 산학협력단 X-링크된 부신백질이영양증 예방 또는 치료용 물질 스크리닝 방법
JP2022544702A (ja) * 2019-08-19 2022-10-20 ストーク セラピューティクス，インク． スプライシングおよびタンパク質発現を調節するための組成物および方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"ACCESSION NO. NM_000033.4, Homo Sapiens ATP binding cassette subfamily D member 1 (ABCD1), mRNA", GENBANK[ONLINE], JPN6024040052, 26 August 2019 (2019-08-26), ISSN: 0005562936 *
KOK, F ET AL.: "Mutational Analysis of Patients With X-Linked Adrenoleukodystrophy", HUMAN MUTATION, vol. 6, JPN6024040051, 1995, pages 104 - 115, ISSN: 0005432608 *

Also Published As

Publication number Publication date
KR20220054401A (ko) 2022-05-02
CA3153071A1 (en) 2021-03-11
CN116171198A (zh) 2023-05-26
EP4025345A1 (en) 2022-07-13
IL291080A (en) 2022-05-01
EP4025345A4 (en) 2024-02-28
US20220259682A1 (en) 2022-08-18
AU2020343336A1 (en) 2022-03-24
WO2021046278A1 (en) 2021-03-11

Similar Documents

Publication Publication Date Title
Jalandra et al. Strategies and perspectives to develop SARS-CoV-2 detection methods and diagnostics
Mahapatra et al. Clinically practiced and commercially viable nanobio engineered analytical methods for COVID-19 diagnosis
JP2022547023A (ja) 感染の宿主ｒｎａバイオマーカーの迅速な早期検出及びヒトにおけるｃｏｖｉｄ－１９コロナウイルス感染の早期同定のためのシステム、方法、及び組成物。
Fooks et al. Emerging technologies for the detection of rabies virus: challenges and hopes in the 21st century
US8821876B2 (en) Methods of identifying infectious disease and assays for identifying infectious disease
US20110183856A1 (en) Diagnosis and Prognosis of Infectious Disease Clinical Phenotypes and other Physiologic States Using Host Gene Expression Biomarkers In Blood
Shahrajabian et al. Different methods for molecular and rapid detection of human novel coronavirus
WO2021155728A1 (zh) 新型冠状病毒2019-nCoV核酸检测试剂盒
CN118745485A (zh) 一种基于RPA-CRISPR/Cas12a的猴痘病毒检测体系、检测试剂盒、检测方法及其应用
CA3173190A1 (en) Assays for detecting pathogens
CN113652505B (zh) 检测新型冠状病毒及其voc-202012/01突变株的方法和试剂盒
EP3394291A1 (en) Triage biomarkers and uses therefor
CN109913565B (zh) 一种用于检测副溶血弧菌的试剂盒、引物对、探针及方法
JP2023501538A (ja) 感染の宿主ｒｎａバイオマーカーの同定
CN113481325B (zh) 检测新型冠状病毒b.1.1.7突变株的方法和试剂盒
CN106435029A (zh) 猫传染性腹膜炎病毒检测用引物组和试剂盒及其检测方法
CN118979116A (zh) 炭疽、鼠疫和布病三重rpa检测试剂盒、引物探针组合物和应用
CN103361405A (zh) Pcr检测解脲脲原体生物群的试剂盒
US20250067739A1 (en) Methods of detecting viral or bacterial infections
Nejad et al. An outlook on coronavirus disease 2019 detection methods
CN116024371A (zh) 一种多重qPCR检测病原菌的引物探针组、试剂盒和检测方法
KR20220040834A (ko) 분자 비콘 프로브를 포함하는 covid-19 진단 멀티플렉스 lamp 조성물
CN112575078A (zh) lncRNAs作为活动性肺结核病特异性标志物的应用
JP2022025456A (ja) 多発性硬化症を検査する方法
CN114262758B (zh) 检测新型冠状病毒突变株的试剂盒及检测方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230901

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230901

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20230901

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20230901

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20241008

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250107

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250401