JP2022545682A - ＩｇＭグリコバリアント - Google Patents

ＩｇＭグリコバリアント Download PDF

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Publication number
JP2022545682A
JP2022545682A JP2022512306A JP2022512306A JP2022545682A JP 2022545682 A JP2022545682 A JP 2022545682A JP 2022512306 A JP2022512306 A JP 2022512306A JP 2022512306 A JP2022512306 A JP 2022512306A JP 2022545682 A JP2022545682 A JP 2022545682A
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JP
Japan
Prior art keywords
igm
seq
amino acid
chain
variant
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JP2022512306A
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English (en)
Japanese (ja)
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JP2022545682A5 (enExample
Inventor
ブルース ケイト
ディーン エン
ラメシュ バリガ
Original Assignee
アイジーエム バイオサイエンシズ インコーポレイテッド
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Publication of JP2022545682A5 publication Critical patent/JP2022545682A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022512306A 2019-08-23 2020-08-21 ＩｇＭグリコバリアント Ceased JP2022545682A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962891263P 2019-08-23 2019-08-23
US62/891,263 2019-08-23
PCT/US2020/047495 WO2021041250A1 (en) 2019-08-23 2020-08-21 Igm glycovariants

Publications (2)

Publication Number Publication Date
JP2022545682A true JP2022545682A (ja) 2022-10-28
JP2022545682A5 JP2022545682A5 (enExample) 2023-08-16

Family

ID=74684266

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022512306A Ceased JP2022545682A (ja) 2019-08-23 2020-08-21 ＩｇＭグリコバリアント

Country Status (11)

Country Link
US (1) US20220306760A1 (enExample)
EP (1) EP4017533A4 (enExample)
JP (1) JP2022545682A (enExample)
KR (1) KR20220050166A (enExample)
CN (1) CN114269380A (enExample)
AU (1) AU2020337333A1 (enExample)
BR (1) BR112022003282A2 (enExample)
CA (1) CA3149350A1 (enExample)
IL (1) IL290253A (enExample)
MX (1) MX2022002239A (enExample)
WO (1) WO2021041250A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4011910A1 (en) 2014-04-03 2022-06-15 IGM Biosciences, Inc. Modified j-chain
PT3247728T (pt) 2015-01-20 2020-07-16 Igm Biosciences Inc Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas
WO2016154593A1 (en) 2015-03-25 2016-09-29 Igm Biosciences, Inc. Multi-valent hepatitis b virus antigen binding molecules and uses thereof
ES2819870T3 (es) 2015-09-30 2021-04-19 Igm Biosciences Inc Moléculas de unión con cadena J modificada
PT3355913T (pt) 2015-09-30 2024-12-18 Igm Biosciences Inc Moléculas de ligação com cadeia j modificada
CN111787951B (zh) 2018-03-01 2025-06-17 Igm生物科学股份有限公司 影响IgM血清半衰期的IgM Fc和J链突变
KR20220035369A (ko) 2019-06-07 2022-03-22 아디맵 엘엘씨 고 친화도 항-cd3 항체, 및 이의 생성 및 사용 방법
CA3231006A1 (en) * 2021-09-17 2023-03-23 Adimab, Llc Anti-cd3 antibodies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019502694A (ja) * 2015-12-18 2019-01-31 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 二特異性抗体基幹

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0809042B1 (pt) * 2007-03-22 2021-08-31 Biogen Ma Inc. Proteína de ligação a cd154 isolada, seu uso, e composição
CA2780221A1 (en) * 2009-11-04 2011-05-12 Fabrus Llc Methods for affinity maturation-based antibody optimization
EP4011910A1 (en) * 2014-04-03 2022-06-15 IGM Biosciences, Inc. Modified j-chain
PT3355913T (pt) * 2015-09-30 2024-12-18 Igm Biosciences Inc Moléculas de ligação com cadeia j modificada
EP3571222A4 (en) * 2017-01-19 2021-06-16 Cedars-Sinai Medical Center METHOD BASED ON HIGHLY MULTIPLEX AND MASS SPECTROMETRY FOR MEASURING HUMAN 72 PROTEINS
EP3600442A1 (en) * 2017-03-22 2020-02-05 Genentech, Inc. Optimized antibody compositions for treatment of ocular disorders
CN111417651B (zh) * 2017-12-01 2023-09-29 诺华股份有限公司 多瘤病毒中和抗体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019502694A (ja) * 2015-12-18 2019-01-31 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 二特異性抗体基幹

Also Published As

Publication number Publication date
CN114269380A (zh) 2022-04-01
IL290253A (en) 2022-04-01
AU2020337333A1 (en) 2022-03-03
EP4017533A4 (en) 2024-03-27
US20220306760A1 (en) 2022-09-29
EP4017533A1 (en) 2022-06-29
MX2022002239A (es) 2022-03-22
KR20220050166A (ko) 2022-04-22
CA3149350A1 (en) 2021-03-04
BR112022003282A2 (pt) 2022-05-24
WO2021041250A1 (en) 2021-03-04

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