BR112022003282A2 - Glicovariantes de igm - Google Patents
Glicovariantes de igmInfo
- Publication number
- BR112022003282A2 BR112022003282A2 BR112022003282A BR112022003282A BR112022003282A2 BR 112022003282 A2 BR112022003282 A2 BR 112022003282A2 BR 112022003282 A BR112022003282 A BR 112022003282A BR 112022003282 A BR112022003282 A BR 112022003282A BR 112022003282 A2 BR112022003282 A2 BR 112022003282A2
- Authority
- BR
- Brazil
- Prior art keywords
- igm
- heavy chain
- variant
- derived
- glycovariants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
glicovariantes de igm referência cruzada a pedidos relacionados. esta divulgação fornece uma molécula de ligação derivada de igm isolada, por exemplo, um anticorpo igm, anticorpo semelhante a igm ou outra molécula de ligação derivada de igm, incluindo pelo menos uma cadeia pesada derivada da igm variante, onde a pelo menos uma cadeia pesada derivada da igm variante inclui uma região constante de cadeia pesada da igm variante associada a um domínio de ligação que se liga especificamente a um alvo, onde pelo menos um motivo de gli-cosilação (n)-ligado de asparagina da região constante de cadeia pesada da igm variante é mutado para evitar a glicosilação nesse motivo, e/ou pelo menos um mo-tivo de glicosilação n-ligado é introduzido na cadeia pesada da igm variante.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962891263P | 2019-08-23 | 2019-08-23 | |
PCT/US2020/047495 WO2021041250A1 (en) | 2019-08-23 | 2020-08-21 | Igm glycovariants |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022003282A2 true BR112022003282A2 (pt) | 2022-05-24 |
Family
ID=74684266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022003282A BR112022003282A2 (pt) | 2019-08-23 | 2020-08-21 | Glicovariantes de igm |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220306760A1 (pt) |
EP (1) | EP4017533A4 (pt) |
JP (1) | JP2022545682A (pt) |
KR (1) | KR20220050166A (pt) |
CN (1) | CN114269380A (pt) |
AU (1) | AU2020337333A1 (pt) |
BR (1) | BR112022003282A2 (pt) |
CA (1) | CA3149350A1 (pt) |
IL (1) | IL290253A (pt) |
MX (1) | MX2022002239A (pt) |
WO (1) | WO2021041250A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3126383T3 (en) | 2014-04-03 | 2019-04-01 | Igm Biosciences Inc | MODIFIED J-CHAIN |
JP7179464B2 (ja) | 2015-01-20 | 2022-11-29 | アイジーエム バイオサイエンシズ インコーポレイテッド | 腫瘍壊死因子 (tnf) スーパーファミリー受容体結合分子およびその使用 |
AU2016238246B2 (en) | 2015-03-25 | 2021-05-13 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
AU2016329197B2 (en) | 2015-09-30 | 2021-01-21 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
DK3356401T3 (da) | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
IL311039A (en) * | 2021-09-17 | 2024-04-01 | Adimab Llc | Anti-CD3 antibodies |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2125894T1 (sl) * | 2007-03-22 | 2019-05-31 | Biogen Ma Inc. | Vezavne beljakovine, vključno s protitelesi, derivati protiteles in fragmenti protiteles, ki specifično vežejo CD154, ter njihove uporabe |
EP2496600A1 (en) * | 2009-11-04 | 2012-09-12 | Fabrus LLC | Methods for affinity maturation-based antibody optimization |
AU2016329197B2 (en) * | 2015-09-30 | 2021-01-21 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
WO2017106462A1 (en) * | 2015-12-18 | 2017-06-22 | Biogen Ma Inc. | Bispecific antibody platform |
WO2018136825A1 (en) * | 2017-01-19 | 2018-07-26 | Cedars-Sinai Medical Center | Highly multiplexed and mass spectrometry based methods to measuring 72 human proteins |
WO2018175752A1 (en) * | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Optimized antibody compositions for treatment of ocular disorders |
CA3083363A1 (en) * | 2017-12-01 | 2019-06-06 | Novartis Ag | Polyomavirus neutralizing antibodies |
-
2020
- 2020-08-21 KR KR1020227008888A patent/KR20220050166A/ko unknown
- 2020-08-21 CN CN202080059541.5A patent/CN114269380A/zh active Pending
- 2020-08-21 BR BR112022003282A patent/BR112022003282A2/pt unknown
- 2020-08-21 US US17/637,349 patent/US20220306760A1/en active Pending
- 2020-08-21 WO PCT/US2020/047495 patent/WO2021041250A1/en active Application Filing
- 2020-08-21 MX MX2022002239A patent/MX2022002239A/es unknown
- 2020-08-21 CA CA3149350A patent/CA3149350A1/en active Pending
- 2020-08-21 EP EP20859308.7A patent/EP4017533A4/en active Pending
- 2020-08-21 JP JP2022512306A patent/JP2022545682A/ja active Pending
- 2020-08-21 AU AU2020337333A patent/AU2020337333A1/en active Pending
-
2022
- 2022-01-31 IL IL290253A patent/IL290253A/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2022002239A (es) | 2022-03-22 |
EP4017533A1 (en) | 2022-06-29 |
AU2020337333A1 (en) | 2022-03-03 |
CA3149350A1 (en) | 2021-03-04 |
US20220306760A1 (en) | 2022-09-29 |
KR20220050166A (ko) | 2022-04-22 |
JP2022545682A (ja) | 2022-10-28 |
WO2021041250A1 (en) | 2021-03-04 |
IL290253A (en) | 2022-04-01 |
CN114269380A (zh) | 2022-04-01 |
EP4017533A4 (en) | 2024-03-27 |
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