|
US99823A
(en)
|
|
1870-02-15 |
|
Improved indigo soap |
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US5097025A
(en)
|
1989-08-01 |
1992-03-17 |
The Rockefeller University |
Plant promoters
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US5608144A
(en)
|
1994-08-12 |
1997-03-04 |
Dna Plant Technology Corp. |
Plant group 2 promoters and uses thereof
|
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5783393A
(en)
|
1996-01-29 |
1998-07-21 |
Agritope, Inc. |
Plant tissue/stage specific promoters for regulated expression of transgenes in plants
|
|
US5846946A
(en)
|
1996-06-14 |
1998-12-08 |
Pasteur Merieux Serums Et Vaccins |
Compositions and methods for administering Borrelia DNA
|
|
US5880330A
(en)
|
1996-08-07 |
1999-03-09 |
The Salk Institute For Biological Studies |
Shoot meristem specific promoter sequences
|
|
AU733310C
(en)
|
1997-05-14 |
2001-11-29 |
University Of British Columbia, The |
High efficiency encapsulation of charged therapeutic agents in lipid vesicles
|
|
US6693086B1
(en)
|
1998-06-25 |
2004-02-17 |
National Jewish Medical And Research Center |
Systemic immune activation method using nucleic acid-lipid complexes
|
|
EP1083231A1
(en)
|
1999-09-09 |
2001-03-14 |
Introgene B.V. |
Smooth muscle cell promoter and uses thereof
|
|
US6291666B1
(en)
|
2000-05-12 |
2001-09-18 |
The United States Of America As Represented By The Secretary Of Agriculture |
Spike tissue-specific promoter
|
|
WO2002012450A1
(en)
|
2000-08-07 |
2002-02-14 |
Texas Tech University |
Gossypium hirsutum tissue-specific promoters and their use
|
|
EP1207204A1
(de)
|
2000-11-16 |
2002-05-22 |
KWS Saat AG |
Gewebespezifische Promotoren aus der Zuckerrübe
|
|
ATE307891T1
(de)
|
2001-01-17 |
2005-11-15 |
Temasek Life Sciences Lab Ltd |
Isolierung und charakterisierung eines antheren- spezifischen promotors (cofs) aus baumwolle
|
|
WO2002087541A1
(en)
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Lipid-based formulations for gene transfer
|
|
US7169874B2
(en)
|
2001-11-02 |
2007-01-30 |
Bausch & Lomb Incorporated |
High refractive index polymeric siloxysilane compositions
|
|
JP4638225B2
(ja)
|
2002-05-30 |
2011-02-23 |
ザ スクリプス リサーチ インスティテュート |
銅を触媒とするアジドとアセチレンのライゲーション
|
|
EP1589813B1
(en)
|
2003-01-03 |
2015-02-25 |
The Texas A & M University System |
Stem-regulated, plant defense promoter and uses thereof in tissue-specific expression in monocots
|
|
US7253276B2
(en)
|
2003-01-03 |
2007-08-07 |
The Texas A&M University System |
Stem-regulated, plant defense promoter and uses thereof in tissue-specific expression in monocots
|
|
SE0301233D0
(sv)
|
2003-04-28 |
2003-04-28 |
Swetree Technologies Ab |
Tissue specific promoters
|
|
EP1664316B1
(en)
|
2003-09-15 |
2012-08-29 |
Protiva Biotherapeutics Inc. |
Polyethyleneglycol-modified lipid compounds and uses thereof
|
|
US7238512B2
(en)
|
2003-10-17 |
2007-07-03 |
E. I. Du Pont De Nemours And Company |
Method to produce para-hydroxybenzoic acid in the stem tissue of green plants by using a tissue-specific promoter
|
|
US7070941B2
(en)
|
2003-11-17 |
2006-07-04 |
Board Of Regents, The University Of Texas System |
Methods and compositions for tagging via azido substrates
|
|
EP1751180A4
(en)
|
2004-02-26 |
2012-01-04 |
Israel State |
ENZYMES, CELLS, AND METHODS FOR LOCALLY-SPECIFIC RECOMBINATION AT ASYMMETRIC LOCATIONS
|
|
JP4380411B2
(ja)
|
2004-04-30 |
2009-12-09 |
澁谷工業株式会社 |
滅菌方法
|
|
WO2006069782A2
(en)
|
2004-12-27 |
2006-07-06 |
Silence Therapeutics Ag. |
Lipid complexes coated with peg and their use
|
|
US20060014264A1
(en)
*
|
2004-07-13 |
2006-01-19 |
Stowers Institute For Medical Research |
Cre/lox system with lox sites having an extended spacer region
|
|
AU2005274948B2
(en)
|
2004-07-16 |
2011-09-22 |
Genvec, Inc. |
Vaccines against aids comprising CMV/R-nucleic acid constructs
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
JP2009534690A
(ja)
|
2006-07-10 |
2009-09-24 |
メムシック,インコーポレイテッド |
磁場センサーを用いて偏揺れを感知するためのシステム、および、前記システムを用いた携帯用の電子装置
|
|
US8404658B2
(en)
|
2007-12-31 |
2013-03-26 |
Nanocor Therapeutics, Inc. |
RNA interference for the treatment of heart failure
|
|
WO2009086558A1
(en)
|
2008-01-02 |
2009-07-09 |
Tekmira Pharmaceuticals Corporation |
Improved compositions and methods for the delivery of nucleic acids
|
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
|
WO2009132131A1
(en)
|
2008-04-22 |
2009-10-29 |
Alnylam Pharmaceuticals, Inc. |
Amino lipid based improved lipid formulation
|
|
US8394604B2
(en)
|
2008-04-30 |
2013-03-12 |
Paul Xiang-Qin Liu |
Protein splicing using short terminal split inteins
|
|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
US8945885B2
(en)
|
2008-07-03 |
2015-02-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Minicircle DNA vector preparations and methods of making and using the same
|
|
WO2010028347A2
(en)
|
2008-09-05 |
2010-03-11 |
President & Fellows Of Harvard College |
Continuous directed evolution of proteins and nucleic acids
|
|
CA2740000C
(en)
|
2008-10-09 |
2017-12-12 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
MX360460B
(es)
|
2008-10-20 |
2018-11-05 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para inhibir la expresion de transtiretina.
|
|
CN111808084A
(zh)
|
2008-11-10 |
2020-10-23 |
阿布特斯生物制药公司 |
用于递送治疗剂的新型脂质和组合物
|
|
US8722082B2
(en)
|
2008-11-10 |
2014-05-13 |
Tekmira Pharmaceuticals Corporation |
Lipids and compositions for the delivery of therapeutics
|
|
EP3243504A1
(en)
|
2009-01-29 |
2017-11-15 |
Arbutus Biopharma Corporation |
Improved lipid formulation
|
|
KR101766408B1
(ko)
|
2009-06-10 |
2017-08-10 |
알닐람 파마슈티칼스 인코포레이티드 |
향상된 지질 조성물
|
|
WO2010149170A1
(en)
|
2009-06-24 |
2010-12-29 |
Københavns Universitet |
Treatment of insulin resistance and obesity by stimulating glp-1 release
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
WO2011000107A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
|
ES2579936T3
(es)
|
2009-08-20 |
2016-08-17 |
Sirna Therapeutics, Inc. |
Nuevos lípidos catiónicos con diversos grupos de cabeza para el suministro oligonucleotídico
|
|
WO2011066651A1
(en)
|
2009-12-01 |
2011-06-09 |
Protiva Biotherapeutics, Inc. |
Snalp formulations containing antioxidants
|
|
EP3296398A1
(en)
|
2009-12-07 |
2018-03-21 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
|
EP2525781A1
(en)
|
2010-01-22 |
2012-11-28 |
Schering Corporation |
Novel cationic lipids for oligonucleotide delivery
|
|
US20130123338A1
(en)
|
2010-05-12 |
2013-05-16 |
Protiva Biotherapeutics, Inc. |
Novel cationic lipids and methods of use thereof
|
|
WO2011141704A1
(en)
|
2010-05-12 |
2011-11-17 |
Protiva Biotherapeutics, Inc |
Novel cyclic cationic lipids and methods of use
|
|
DK2575767T3
(en)
|
2010-06-04 |
2017-03-13 |
Sirna Therapeutics Inc |
HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES
|
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
MX2013002332A
(es)
|
2010-08-31 |
2013-03-18 |
Novartis Ag |
Lipidos apropiados para suministro liposomal del arn que codifica la proteina.
|
|
CA2809858C
(en)
|
2010-09-20 |
2019-11-12 |
Sirna Therapeutics, Inc. |
Novel low molecular weight cationic lipids for oligonucleotide delivery
|
|
CA2811430A1
(en)
|
2010-09-30 |
2012-04-05 |
Merck Sharp & Dohme Corp. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
EP3485913A1
(en)
|
2010-10-21 |
2019-05-22 |
Sirna Therapeutics, Inc. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
US9617461B2
(en)
|
2010-12-06 |
2017-04-11 |
Schlumberger Technology Corporation |
Compositions and methods for well completions
|
|
CA2825370A1
(en)
|
2010-12-22 |
2012-06-28 |
President And Fellows Of Harvard College |
Continuous directed evolution
|
|
CA2824526C
(en)
|
2011-01-11 |
2020-07-07 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
|
WO2012162210A1
(en)
|
2011-05-26 |
2012-11-29 |
Merck Sharp & Dohme Corp. |
Ring constrained cationic lipids for oligonucleotide delivery
|
|
WO2013016058A1
(en)
|
2011-07-22 |
2013-01-31 |
Merck Sharp & Dohme Corp. |
Novel bis-nitrogen containing cationic lipids for oligonucleotide delivery
|
|
US8846883B2
(en)
|
2011-08-16 |
2014-09-30 |
University Of Southhampton |
Oligonucleotide ligation
|
|
EP3456317B1
(en)
|
2011-09-27 |
2025-09-24 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
|
AU2012347605B2
(en)
|
2011-12-07 |
2017-09-21 |
Alnylam Pharmaceuticals, Inc. |
Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
|
|
WO2013086354A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
JP6182457B2
(ja)
|
2011-12-12 |
2017-08-16 |
協和発酵キリン株式会社 |
カチオン性脂質を含有するドラックデリバリーシステムのための脂質ナノ粒子
|
|
WO2013116126A1
(en)
|
2012-02-01 |
2013-08-08 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight, biodegradable cationic lipids for oligonucleotide delivery
|
|
EP2817287B1
(en)
|
2012-02-24 |
2018-10-03 |
Arbutus Biopharma Corporation |
Trialkyl cationic lipids and methods of use thereof
|
|
AU2013201287B2
(en)
|
2012-03-06 |
2015-05-14 |
Duke University |
Synthetic regulation of gene expression
|
|
AU2013240051B2
(en)
|
2012-03-27 |
2017-11-30 |
Sirna Therapeutics, Inc. |
Diether based biodegradable cationic lipids for siRNA delivery
|
|
EP3431497B1
(en)
|
2012-06-27 |
2022-07-27 |
The Trustees of Princeton University |
Split inteins, conjugates and uses thereof
|
|
CN107879960B
(zh)
|
2013-03-08 |
2021-06-22 |
诺华股份有限公司 |
用于传递活性成分的脂质和脂质组合物
|
|
JP6620093B2
(ja)
|
2013-07-23 |
2019-12-11 |
アービュートゥス バイオファーマ コーポレイションArbutus Biopharma Corporation |
メッセンジャーrnaを送達するための組成物及び方法
|
|
ES3032935T3
(en)
|
2013-10-22 |
2025-07-29 |
Translate Bio Inc |
Lipid formulations for delivery of messenger rna
|
|
AU2014348212C1
(en)
|
2013-11-18 |
2018-11-29 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
US9365610B2
(en)
|
2013-11-18 |
2016-06-14 |
Arcturus Therapeutics, Inc. |
Asymmetric ionizable cationic lipid for RNA delivery
|
|
US10426737B2
(en)
|
2013-12-19 |
2019-10-01 |
Novartis Ag |
Lipids and lipid compositions for the delivery of active agents
|
|
EP3083556B1
(en)
|
2013-12-19 |
2019-12-25 |
Novartis AG |
Lipids and lipid compositions for the delivery of active agents
|
|
WO2015134121A2
(en)
|
2014-01-20 |
2015-09-11 |
President And Fellows Of Harvard College |
Negative selection and stringency modulation in continuous evolution systems
|
|
HUE060907T2
(hu)
|
2014-06-25 |
2023-04-28 |
Acuitas Therapeutics Inc |
Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére
|
|
US9879283B2
(en)
|
2014-10-09 |
2018-01-30 |
Life Technologies Corporation |
CRISPR oligonucleotides and gene editing
|
|
WO2016168631A1
(en)
|
2015-04-17 |
2016-10-20 |
President And Fellows Of Harvard College |
Vector-based mutagenesis system
|
|
PT3313829T
(pt)
|
2015-06-29 |
2024-07-08 |
Acuitas Therapeutics Inc |
Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos
|
|
WO2017015545A1
(en)
*
|
2015-07-22 |
2017-01-26 |
President And Fellows Of Harvard College |
Evolution of site-specific recombinases
|
|
HRP20230209T1
(hr)
|
2015-10-28 |
2023-04-14 |
Acuitas Therapeutics Inc. |
Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
|
|
PL3386484T3
(pl)
|
2015-12-10 |
2022-07-25 |
Modernatx, Inc. |
Kompozycje i sposoby dostarczania środków terapeutycznych
|
|
WO2017117528A1
(en)
|
2015-12-30 |
2017-07-06 |
Acuitas Therapeutics, Inc. |
Lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
PT3408292T
(pt)
|
2016-01-29 |
2023-07-19 |
Univ Princeton |
Inteínas divididas com excecional atividade de splicing
|
|
LT3436077T
(lt)
|
2016-03-30 |
2025-06-25 |
Intellia Therapeutics, Inc. |
Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams
|
|
WO2017223135A1
(en)
|
2016-06-24 |
2017-12-28 |
Modernatx, Inc. |
Lipid nanoparticles
|
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
AU2018269050A1
(en)
|
2017-05-19 |
2020-01-16 |
Encoded Therapeutics, Inc. |
High activity regulatory elements
|
|
IL271275B1
(en)
|
2017-06-13 |
2026-04-01 |
Flagship Pioneering Innovations V Inc |
Preparations containing croons and their uses
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
KR102696307B1
(ko)
|
2017-09-08 |
2024-08-16 |
제너레이션 바이오 컴퍼니 |
비-바이러스성 캡시드-비함유 dna 벡터의 지질 나노입자 제형
|
|
WO2019067910A1
(en)
|
2017-09-29 |
2019-04-04 |
Intellia Therapeutics, Inc. |
POLYNUCLEOTIDES, COMPOSITIONS AND METHODS FOR GENOMIC EDITION
|
|
US20230140670A1
(en)
|
2017-09-29 |
2023-05-04 |
Intellia Therapeutics, Inc. |
Formulations
|
|
WO2019094253A1
(en)
|
2017-11-08 |
2019-05-16 |
Avexis Inc. |
Means and method for preparing viral vectors and uses of same
|
|
WO2019178427A1
(en)
|
2018-03-14 |
2019-09-19 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
|
CN119570787A
(zh)
|
2018-05-11 |
2025-03-07 |
比姆医疗股份有限公司 |
使用可编程碱基编辑器系统遏止病原性突变的方法
|
|
CN112955174A
(zh)
|
2018-07-09 |
2021-06-11 |
旗舰先锋创新V股份有限公司 |
融合剂脂质体组合物和其用途
|
|
EP3847254A4
(en)
|
2018-09-07 |
2022-08-10 |
Beam Therapeutics Inc. |
COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
|
|
WO2020061457A1
(en)
|
2018-09-20 |
2020-03-26 |
Modernatx, Inc. |
Preparation of lipid nanoparticles and methods of administration thereof
|