JP2022542431A5 - - Google Patents
Info
- Publication number
- JP2022542431A5 JP2022542431A5 JP2022506359A JP2022506359A JP2022542431A5 JP 2022542431 A5 JP2022542431 A5 JP 2022542431A5 JP 2022506359 A JP2022506359 A JP 2022506359A JP 2022506359 A JP2022506359 A JP 2022506359A JP 2022542431 A5 JP2022542431 A5 JP 2022542431A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- variable region
- chain variable
- multispecific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962880347P | 2019-07-30 | 2019-07-30 | |
| US62/880,347 | 2019-07-30 | ||
| PCT/US2020/070334 WO2021022304A2 (en) | 2019-07-30 | 2020-07-30 | MULTISPECIFIC BINDING COMPOUNDS THAT BIND TO LRRC15 AND CD3ε |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022542431A JP2022542431A (ja) | 2022-10-03 |
| JP2022542431A5 true JP2022542431A5 (enExample) | 2023-08-08 |
Family
ID=72145539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506359A Pending JP2022542431A (ja) | 2019-07-30 | 2020-07-30 | 二重特異性抗ｌｒｒｃ１５及びｃｄ３イプシロン抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230374130A1 (enExample) |
| EP (1) | EP4004050A2 (enExample) |
| JP (1) | JP2022542431A (enExample) |
| CN (2) | CN120842421A (enExample) |
| CA (1) | CA3146341A1 (enExample) |
| WO (1) | WO2021022304A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117120477A (zh) * | 2020-11-10 | 2023-11-24 | 上海齐鲁制药研究中心有限公司 | 针对密蛋白18a2和cd3的双特异性抗体及其应用 |
| US20240294640A1 (en) * | 2021-06-02 | 2024-09-05 | Qure Biotechnology (Shanghai) Co., Ltd. | Anti-cd3 antibody variant, fusion protein, and application |
| KR20240040097A (ko) * | 2021-08-04 | 2024-03-27 | 에이비프로 코퍼레이션 | Cd3 표적화 항체 및 이의 용도 |
| WO2023036215A1 (zh) * | 2021-09-08 | 2023-03-16 | 上海齐鲁制药研究中心有限公司 | 双特异性抗原结合分子及其应用 |
| CN116253802A (zh) * | 2021-12-10 | 2023-06-13 | 苏州泽璟生物制药股份有限公司 | 包含lrrc15抗原结合结构域的多特异性t细胞接合剂 |
| KR20250042205A (ko) * | 2022-06-27 | 2025-03-26 | 에스씨지 셀 테라피 피티이. 리미티드 | HBV 표면 항원 (HBsAg) 및 CD3에 대한 이중 특이적 항체 및 이의 용도 |
| WO2024036139A2 (en) * | 2022-08-09 | 2024-02-15 | Qlsf Biotherapeutics, Inc. | Antibodies binding to clec12a |
| CN120035607A (zh) * | 2022-10-12 | 2025-05-23 | 神话治疗股份有限公司 | Lrrc-15结合蛋白构建体及其用途 |
| TW202432596A (zh) | 2022-11-01 | 2024-08-16 | 大陸商上海齊魯製藥研究中心有限公司 | 針對磷脂醯肌醇蛋白聚醣3的雙特異性抗體及其應用 |
| WO2025064369A1 (en) * | 2023-09-18 | 2025-03-27 | Modernatx, Inc. | Humanized anti-cd3 binding molecules and uses thereof |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025201242A1 (en) * | 2024-03-25 | 2025-10-02 | Tavotek Biotherapeutics (Hong Kong) Limited | Antibodies targeting fap and lrrc15 and fusion proteins targeting hyaluronan and uses thereof |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| MXPA05004677A (es) | 2002-10-31 | 2005-11-17 | Genentech Inc | Metodos y composiciones para aumentar la produccion de anticuerpos. |
| WO2004065417A2 (en) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| US20050239700A1 (en) * | 2003-10-14 | 2005-10-27 | Biogen Idec Inc. | Treatment of cancer using antibodies to LRRC15 |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| CN101952312A (zh) | 2007-07-31 | 2011-01-19 | 米迪缪尼有限公司 | 多特异性表位结合蛋白及其应用 |
| CN102421801B (zh) | 2009-03-10 | 2016-03-16 | 比奥根Ma公司 | 抗-bcma抗体 |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| EP3904391B1 (en) | 2010-03-10 | 2024-07-10 | Genmab A/S | Monoclonal antibodies against c-met |
| TWI653333B (zh) * | 2010-04-01 | 2019-03-11 | 安進研究（慕尼黑）有限責任公司 | 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體 |
| KR102391731B1 (ko) * | 2013-01-14 | 2022-04-27 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
| EP2970485A1 (en) | 2013-03-15 | 2016-01-20 | Merck Patent GmbH | Tetravalent bispecific antibodies |
| US10259887B2 (en) * | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| US10323094B2 (en) * | 2015-06-16 | 2019-06-18 | Genentech, Inc. | Humanized and affinity matured antibodies to FcRH5 and methods of use |
| CA2992797A1 (en) * | 2015-08-03 | 2017-02-09 | Engmab Sarl | Monoclonal antibodies against bcma |
| EP3383909B1 (en) | 2015-11-30 | 2020-06-17 | AbbVie Inc. | Anti-human lrrc15 antibody drug conjugates and methods for their use |
| JP2019501124A (ja) * | 2015-11-30 | 2019-01-17 | アッヴィ・インコーポレイテッド | 抗ｈｕＬＲＲＣ１５抗体薬物コンジュゲート及びその使用方法 |
| US11291721B2 (en) * | 2016-03-21 | 2022-04-05 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| CR20220578A (es) * | 2016-09-14 | 2023-01-17 | Teneobio Inc | Anticuerpos de unión a cd3 |
| MX2019004327A (es) | 2016-10-14 | 2019-10-14 | Xencor Inc | Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15ra y fragmentos de anticuerpo pd-1. |
-
2020
- 2020-07-30 CN CN202510512319.0A patent/CN120842421A/zh active Pending
- 2020-07-30 CA CA3146341A patent/CA3146341A1/en active Pending
- 2020-07-30 CN CN202080061357.4A patent/CN114341186B/zh active Active
- 2020-07-30 US US17/588,086 patent/US20230374130A1/en not_active Abandoned
- 2020-07-30 EP EP20758074.7A patent/EP4004050A2/en not_active Withdrawn
- 2020-07-30 WO PCT/US2020/070334 patent/WO2021022304A2/en not_active Ceased
- 2020-07-30 JP JP2022506359A patent/JP2022542431A/ja active Pending
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