JP2022542321A - 免疫療法のためのnk細胞組成物および調製物ならびにそれらの製造のための方法 - Google Patents

免疫療法のためのnk細胞組成物および調製物ならびにそれらの製造のための方法 Download PDF

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JP2022542321A
JP2022542321A JP2022506145A JP2022506145A JP2022542321A JP 2022542321 A JP2022542321 A JP 2022542321A JP 2022506145 A JP2022506145 A JP 2022506145A JP 2022506145 A JP2022506145 A JP 2022506145A JP 2022542321 A JP2022542321 A JP 2022542321A
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コリーン ディレーニー,
キャリー ストルツマン,
エリザベス ダム,
メアリー プリーブ,
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デヴェラ セラピューティクス インコーポレイテッド
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JP2022506145A 2019-07-29 2020-07-29 免疫療法のためのnk細胞組成物および調製物ならびにそれらの製造のための方法 Withdrawn JP2022542321A (ja)

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JP2025105888A JP2025156345A (ja) 2019-07-29 2025-06-23 免疫療法のためのnk細胞組成物および調製物ならびにそれらの製造のための方法

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US201962880044P 2019-07-29 2019-07-29
US62/880,044 2019-07-29
US201962892779P 2019-08-28 2019-08-28
US62/892,779 2019-08-28
US202062960507P 2020-01-13 2020-01-13
US62/960,507 2020-01-13
PCT/US2020/044117 WO2021021963A1 (en) 2019-07-29 2020-07-29 Nk cell composition and preparations for immunotherapy and methods for their production

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CA3125503A1 (en) * 2019-01-18 2020-07-23 Acepodia Biotechnologies Ltd. A novel cd16+ natural killer cell and a method of culturing cd16+ natural killer cell
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
EP4127188A4 (en) * 2020-03-31 2024-08-21 Walking Fish Therapeutics MODIFIED B CELLS AND METHODS OF USE THEREOF
CN113402620B (zh) * 2021-07-30 2021-12-10 中山大学 细胞因子联合嵌合抗原受体的融合蛋白及其应用
CN118119636A (zh) * 2021-08-10 2024-05-31 盖米达细胞有限公司 抗her2 car nk细胞、它们的生产方法及其用途
US20250017964A1 (en) * 2021-11-15 2025-01-16 City Of Hope Engineering or inducing pdgf and/or pdgfr signaling to enhance nk cell therapy
CN114891744B (zh) * 2022-07-13 2022-10-25 山东省齐鲁干细胞工程有限公司 一种冷冻脐带血nk细胞体外扩增方法
WO2024047368A1 (en) * 2022-09-02 2024-03-07 Imperial College Innovations Limited Natural killer cells
WO2024113294A1 (zh) * 2022-12-01 2024-06-06 血霁生物科技(上海)有限公司 一种分化nk细胞的方法、培养基及其应用
CN115927180A (zh) * 2022-12-01 2023-04-07 血霁生物科技(上海)有限公司 一种分化nk细胞的方法、培养基及其应用
CN116769722B (zh) * 2023-07-04 2024-07-16 杭州荣谷生物科技有限公司 功能增强型car-nk细胞、其制备方法及其在免疫疗法中的应用
CN116983409B (zh) * 2023-07-17 2025-11-14 中国检验检疫科学研究院 一种抑制寨卡病毒的方法及其应用
CN118853562B (zh) * 2024-07-11 2025-08-29 中国科学院广州生物医药与健康研究院 一种靶向cd19的car-nk细胞及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017141260A (ja) * 2010-04-09 2017-08-17 フレッド ハッチンソン キャンサー リサーチ センター Hlaの適合なしに造血機能を提供するための組成物および方法
JP2018535666A (ja) * 2015-10-15 2018-12-06 セルラリティ インコーポレイテッド ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201216649D0 (en) * 2012-09-18 2012-10-31 Univ Birmingham Agents and methods
US20200163993A1 (en) * 2017-05-09 2020-05-28 Saint Louis University Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017141260A (ja) * 2010-04-09 2017-08-17 フレッド ハッチンソン キャンサー リサーチ センター Hlaの適合なしに造血機能を提供するための組成物および方法
JP2018535666A (ja) * 2015-10-15 2018-12-06 セルラリティ インコーポレイテッド ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用

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