AU2020321953A1 - NK cell composition and preparations for immunotherapy and methods for their production - Google Patents

NK cell composition and preparations for immunotherapy and methods for their production Download PDF

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Publication number
AU2020321953A1
AU2020321953A1 AU2020321953A AU2020321953A AU2020321953A1 AU 2020321953 A1 AU2020321953 A1 AU 2020321953A1 AU 2020321953 A AU2020321953 A AU 2020321953A AU 2020321953 A AU2020321953 A AU 2020321953A AU 2020321953 A1 AU2020321953 A1 AU 2020321953A1
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cells
cell
antigen
cell composition
preparation
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Elizabeth DAM
Colleen Delaney
Mary Prieve
Carrie STOLTZMAN
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Deverra Therapeutics Inc
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Deverra Therapeutics Inc
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C12N2500/00—Specific components of cell culture medium
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AU2020321953A 2019-07-29 2020-07-29 NK cell composition and preparations for immunotherapy and methods for their production Pending AU2020321953A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962880044P 2019-07-29 2019-07-29
US62/880,044 2019-07-29
US201962892779P 2019-08-28 2019-08-28
US62/892,779 2019-08-28
US202062960507P 2020-01-13 2020-01-13
US62/960,507 2020-01-13
PCT/US2020/044117 WO2021021963A1 (en) 2019-07-29 2020-07-29 Nk cell composition and preparations for immunotherapy and methods for their production

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AU2020321953A1 true AU2020321953A1 (en) 2022-02-24

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US (1) US20220275334A1 (https=)
EP (1) EP4004193A4 (https=)
JP (2) JP2022542321A (https=)
KR (1) KR20220038450A (https=)
CN (1) CN114466924A (https=)
AU (1) AU2020321953A1 (https=)
CA (1) CA3145510A1 (https=)
IL (1) IL290080A (https=)
MX (1) MX2022001257A (https=)
WO (1) WO2021021963A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3125503A1 (en) * 2019-01-18 2020-07-23 Acepodia Biotechnologies Ltd. A novel cd16+ natural killer cell and a method of culturing cd16+ natural killer cell
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
EP4127188A4 (en) * 2020-03-31 2024-08-21 Walking Fish Therapeutics MODIFIED B CELLS AND METHODS OF USE THEREOF
CN113402620B (zh) * 2021-07-30 2021-12-10 中山大学 细胞因子联合嵌合抗原受体的融合蛋白及其应用
CN118119636A (zh) * 2021-08-10 2024-05-31 盖米达细胞有限公司 抗her2 car nk细胞、它们的生产方法及其用途
US20250017964A1 (en) * 2021-11-15 2025-01-16 City Of Hope Engineering or inducing pdgf and/or pdgfr signaling to enhance nk cell therapy
CN114891744B (zh) * 2022-07-13 2022-10-25 山东省齐鲁干细胞工程有限公司 一种冷冻脐带血nk细胞体外扩增方法
WO2024047368A1 (en) * 2022-09-02 2024-03-07 Imperial College Innovations Limited Natural killer cells
WO2024113294A1 (zh) * 2022-12-01 2024-06-06 血霁生物科技(上海)有限公司 一种分化nk细胞的方法、培养基及其应用
CN115927180A (zh) * 2022-12-01 2023-04-07 血霁生物科技(上海)有限公司 一种分化nk细胞的方法、培养基及其应用
CN116769722B (zh) * 2023-07-04 2024-07-16 杭州荣谷生物科技有限公司 功能增强型car-nk细胞、其制备方法及其在免疫疗法中的应用
CN116983409B (zh) * 2023-07-17 2025-11-14 中国检验检疫科学研究院 一种抑制寨卡病毒的方法及其应用
CN118853562B (zh) * 2024-07-11 2025-08-29 中国科学院广州生物医药与健康研究院 一种靶向cd19的car-nk细胞及其制备方法和应用

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US20130095079A1 (en) * 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
GB201216649D0 (en) * 2012-09-18 2012-10-31 Univ Birmingham Agents and methods
MY201637A (en) * 2015-10-15 2024-03-06 Celularity Inc Natural killer cells and ilc3 cells and uses thereof
US20200163993A1 (en) * 2017-05-09 2020-05-28 Saint Louis University Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes

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MX2022001257A (es) 2022-05-10
KR20220038450A (ko) 2022-03-28
EP4004193A4 (en) 2024-03-20
WO2021021963A1 (en) 2021-02-04
CA3145510A1 (en) 2021-02-04
IL290080A (en) 2022-03-01
JP2025156345A (ja) 2025-10-14
US20220275334A1 (en) 2022-09-01
JP2022542321A (ja) 2022-09-30
EP4004193A1 (en) 2022-06-01

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