JP2022542294A - 抗体に結合して中和抗体を阻害するための組成物および方法 - Google Patents

抗体に結合して中和抗体を阻害するための組成物および方法 Download PDF

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JP2022542294A
JP2022542294A JP2022505585A JP2022505585A JP2022542294A JP 2022542294 A JP2022542294 A JP 2022542294A JP 2022505585 A JP2022505585 A JP 2022505585A JP 2022505585 A JP2022505585 A JP 2022505585A JP 2022542294 A JP2022542294 A JP 2022542294A
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protein
functional fragment
mycoplasma
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seq
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JP2022542294A5 (https=
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チョンウェン リー
チャールズ アスクー
ブライアン クールマン
デーヴィッド フォレスト シーカー
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University of North Carolina at Chapel Hill
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56933—Mycoplasma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
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    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
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    • G01—MEASURING; TESTING
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JP2022505585A 2019-08-01 2020-07-31 抗体に結合して中和抗体を阻害するための組成物および方法 Pending JP2022542294A (ja)

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US201962881765P 2019-08-01 2019-08-01
US62/881,765 2019-08-01
PCT/US2020/044559 WO2021022187A1 (en) 2019-08-01 2020-07-31 Compositions and methods for binding antibodies and inhibiting neutralizing antibodies

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US (1) US20220260563A1 (https=)
EP (1) EP4007768A4 (https=)
JP (2) JP2022542294A (https=)
KR (1) KR20220053575A (https=)
CN (1) CN114514239A (https=)
AU (1) AU2020319880A1 (https=)
CA (1) CA3149679A1 (https=)
IL (1) IL290219A (https=)
MX (1) MX2022001425A (https=)
WO (1) WO2021022187A1 (https=)

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EP4288445A1 (en) * 2021-02-03 2023-12-13 The University of North Carolina at Chapel Hill Protein m analogs and fusion proteins and their use for inhibiting antibody function
CN116376942A (zh) * 2021-12-31 2023-07-04 广州国家实验室 mRNA疫苗
CN115047188A (zh) * 2022-06-10 2022-09-13 上海鼎新基因科技有限公司 一种抗腺相关病毒中和抗体的检测方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2015117057A2 (en) * 2014-01-31 2015-08-06 The Scripps Research Institute Protein m related immunoglobulin-binding polypeptides

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US5804183A (en) * 1997-01-31 1998-09-08 Enzon, Inc. Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same
HK1202434A1 (en) * 2011-11-22 2015-10-02 The Children's Hospital Of Philadelphia Virus vectors for highly efficient transgene delivery
AU2013204555A1 (en) * 2012-04-30 2013-11-14 Oncolytics Biotech Inc. Protecting modified viruses from neutralizing antibodies using the reovirus sigma 1 protein
US9593150B2 (en) * 2012-07-16 2017-03-14 The Scripps Research Institute Immunoglobulin-binding human mycoplasma antigens and methods of use thereof
EP3204503A1 (en) * 2014-10-06 2017-08-16 Arthrogen BV Aav-based gene therapy
SG11201803098VA (en) * 2015-10-30 2018-05-30 Nbe Therapeutics Ag Anti-ror1 antibodies
DE102016123859B3 (de) * 2016-12-08 2018-03-01 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015117057A2 (en) * 2014-01-31 2015-08-06 The Scripps Research Institute Protein m related immunoglobulin-binding polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GROVER RK. ET AL.: "A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union", SCIENCE, vol. 343, JPN6024032784, 2014, pages 656 - 660, ISSN: 0005395563 *
SAWITRI KN. ET AL.: "Investigating the effect of mutation on the thermo stability of GB1 protein", JOURNAL OF PHYSICS: CONF. SERIES, vol. 1011, JPN6024032785, 2018, pages 012084, ISSN: 0005395564 *

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EP4007768A1 (en) 2022-06-08
US20220260563A1 (en) 2022-08-18
AU2020319880A1 (en) 2022-03-17
KR20220053575A (ko) 2022-04-29
IL290219A (en) 2022-03-01
CA3149679A1 (en) 2021-02-04
WO2021022187A1 (en) 2021-02-04
MX2022001425A (es) 2022-05-02
JP2026000908A (ja) 2026-01-06
EP4007768A4 (en) 2023-11-15
CN114514239A (zh) 2022-05-17

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