|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4309989A
(en)
|
1976-02-09 |
1982-01-12 |
The Curators Of The University Of Missouri |
Topical application of medication by ultrasound with coupling agent
|
|
FR2374910A1
(fr)
|
1976-10-23 |
1978-07-21 |
Choay Sa |
Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4656134A
(en)
|
1982-01-11 |
1987-04-07 |
Board Of Trustees Of Leland Stanford Jr. University |
Gene amplification in eukaryotic cells
|
|
US5149636A
(en)
|
1982-03-15 |
1992-09-22 |
Trustees Of Columbia University In The City Of New York |
Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
GB2183661B
(en)
|
1985-03-30 |
1989-06-28 |
Marc Ballivet |
Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
|
|
US6492107B1
(en)
|
1986-11-20 |
2002-12-10 |
Stuart Kauffman |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
|
SE448277B
(sv)
|
1985-04-12 |
1987-02-09 |
Draco Ab |
Indikeringsanordning vid en doseringsanordning for lekemedel
|
|
US4766067A
(en)
|
1985-05-31 |
1988-08-23 |
President And Fellows Of Harvard College |
Gene amplification
|
|
US4870163A
(en)
|
1985-08-29 |
1989-09-26 |
New York Blood Center, Inc. |
Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US5576195A
(en)
|
1985-11-01 |
1996-11-19 |
Xoma Corporation |
Vectors with pectate lyase signal sequence
|
|
DE3600905A1
(de)
|
1986-01-15 |
1987-07-16 |
Ant Nachrichtentech |
Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
SE453566B
(sv)
|
1986-03-07 |
1988-02-15 |
Draco Ab |
Anordning vid pulverinhalatorer
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4767402A
(en)
|
1986-07-08 |
1988-08-30 |
Massachusetts Institute Of Technology |
Ultrasound enhancement of transdermal drug delivery
|
|
EP0545913B1
(en)
|
1986-08-18 |
1999-02-24 |
Emisphere Technologies, Inc. |
Delivery systems for pharmacological agents
|
|
US4889818A
(en)
|
1986-08-22 |
1989-12-26 |
Cetus Corporation |
Purified thermostable enzyme
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4704692A
(en)
|
1986-09-02 |
1987-11-03 |
Ladner Robert C |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
DE3631229A1
(de)
|
1986-09-13 |
1988-03-24 |
Basf Ag |
Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
|
|
US4921794A
(en)
|
1987-01-14 |
1990-05-01 |
President And Fellows Of Harvard College |
T7 DNA polymerase
|
|
US4795699A
(en)
|
1987-01-14 |
1989-01-03 |
President And Fellows Of Harvard College |
T7 DNA polymerase
|
|
EP0279582A3
(en)
|
1987-02-17 |
1989-10-18 |
Pharming B.V. |
Dna sequences to target proteins to the mammary gland for efficient secretion
|
|
DE3852304T3
(de)
|
1987-03-02 |
1999-07-01 |
Enzon Labs Inc., Piscataway, N.J. |
Organismus als Träger für "Single Chain Antibody Domain (SCAD)".
|
|
EP0288088B1
(en)
|
1987-04-24 |
1994-03-09 |
Teijin Limited |
Detection of tumor necrosis factor; monoclonal antibody and kit
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
CA1341235C
(en)
|
1987-07-24 |
2001-05-22 |
Randy R. Robinson |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US4939666A
(en)
|
1987-09-02 |
1990-07-03 |
Genex Corporation |
Incremental macromolecule construction methods
|
|
DE68926882T2
(de)
|
1988-01-11 |
1997-02-13 |
Xoma Corp |
Plasmidvektor mit pectatlyase-signalsequenz
|
|
US4956288A
(en)
|
1988-04-22 |
1990-09-11 |
Biogen, Inc. |
Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
|
|
US5770198A
(en)
|
1988-05-18 |
1998-06-23 |
The Research Foundation Of The State Of New York |
Platelet-specific chimeric 7E3 immunoglobulin
|
|
US5130238A
(en)
|
1988-06-24 |
1992-07-14 |
Cangene Corporation |
Enhanced nucleic acid amplification process
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5066584A
(en)
|
1988-09-23 |
1991-11-19 |
Cetus Corporation |
Methods for generating single stranded dna by the polymerase chain reaction
|
|
US5142033A
(en)
|
1988-09-23 |
1992-08-25 |
Hoffmann-La Roche Inc. |
Structure-independent DNA amplification by the polymerase chain reaction
|
|
US5091310A
(en)
|
1988-09-23 |
1992-02-25 |
Cetus Corporation |
Structure-independent dna amplification by the polymerase chain reaction
|
|
US4987893A
(en)
|
1988-10-12 |
1991-01-29 |
Rochal Industries, Inc. |
Conformable bandage and coating material
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
EP0368684B2
(en)
|
1988-11-11 |
2004-09-29 |
Medical Research Council |
Cloning immunoglobulin variable domain sequences.
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US4994370A
(en)
|
1989-01-03 |
1991-02-19 |
The United States Of America As Represented By The Department Of Health And Human Services |
DNA amplification technique
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
US5266491A
(en)
|
1989-03-14 |
1993-11-30 |
Mochida Pharmaceutical Co., Ltd. |
DNA fragment and expression plasmid containing the DNA fragment
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
WO1990014443A1
(en)
|
1989-05-16 |
1990-11-29 |
Huse William D |
Co-expression of heteromeric receptors
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
DE69027121T3
(de)
|
1989-08-07 |
2001-08-30 |
Peptech Ltd., Dee Why |
Bindeligande für tumornekrosisfaktor
|
|
DK0494955T3
(da)
|
1989-10-05 |
1998-10-26 |
Optein Inc |
Cellefri syntese og isolering af hidtil ukendte gener og polypeptider
|
|
US5580575A
(en)
|
1989-12-22 |
1996-12-03 |
Imarx Pharmaceutical Corp. |
Therapeutic drug delivery systems
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AU8081491A
(en)
|
1990-06-01 |
1991-12-31 |
Cetus Corporation |
Compositions and methods for identifying biologically active molecules
|
|
US5723286A
(en)
|
1990-06-20 |
1998-03-03 |
Affymax Technologies N.V. |
Peptide library and screening systems
|
|
US5580734A
(en)
|
1990-07-13 |
1996-12-03 |
Transkaryotic Therapies, Inc. |
Method of producing a physical map contigous DNA sequences
|
|
EP0542810A1
(en)
|
1990-08-02 |
1993-05-26 |
B.R. Centre Limited |
Methods for the production of proteins with a desired function
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
WO1992005258A1
(en)
|
1990-09-20 |
1992-04-02 |
La Trobe University |
Gene encoding barley enzyme
|
|
GB9022648D0
(en)
|
1990-10-18 |
1990-11-28 |
Charing Cross Sunley Research |
Polypeptide and its use
|
|
CA2405246A1
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with alterred binding properties
|
|
CA2104698A1
(en)
|
1991-02-21 |
1992-08-22 |
John J. Toole |
Aptamers specific for biomolecules and methods of making
|
|
US5404871A
(en)
|
1991-03-05 |
1995-04-11 |
Aradigm |
Delivery of aerosol medications for inspiration
|
|
DK0575545T3
(da)
|
1991-03-15 |
2003-09-15 |
Amgen Inc |
Pegylering af polypeptider
|
|
DK0580737T3
(da)
|
1991-04-10 |
2004-11-01 |
Scripps Research Inst |
Heterodimere receptorbiblioteker ved anvendelse af phagemider
|
|
WO1993000951A1
(en)
|
1991-07-02 |
1993-01-21 |
Inhale, Inc. |
Method and device for delivering aerosolized medicaments
|
|
US5270170A
(en)
|
1991-10-16 |
1993-12-14 |
Affymax Technologies N.V. |
Peptide library and screening method
|
|
US5641670A
(en)
|
1991-11-05 |
1997-06-24 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
US5733761A
(en)
|
1991-11-05 |
1998-03-31 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
EP1291360A1
(en)
|
1991-12-13 |
2003-03-12 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
|
AU4829593A
(en)
|
1992-09-23 |
1994-04-12 |
Fisons Plc |
Inhalation device
|
|
CA2147260C
(en)
|
1992-10-19 |
1999-04-13 |
Mark Bernard Mecikalski |
Dry powder inhaler
|
|
US5643252A
(en)
|
1992-10-28 |
1997-07-01 |
Venisect, Inc. |
Laser perforator
|
|
WO1994012520A1
(en)
|
1992-11-20 |
1994-06-09 |
Enzon, Inc. |
Linker for linked fusion polypeptides
|
|
US5849695A
(en)
|
1993-01-13 |
1998-12-15 |
The Regents Of The University Of California |
Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals
|
|
ATE172933T1
(de)
|
1993-01-19 |
1998-11-15 |
Glaxo Group Ltd |
Aerosol-spender und verfahren zu seiner herstellung
|
|
CZ206195A3
(en)
|
1993-02-12 |
1996-04-17 |
Univ Leland Stanford Junior |
Controlled transcription of target genes and other biological materials
|
|
US5770428A
(en)
|
1993-02-17 |
1998-06-23 |
Wisconsin Alumni Research Foundation |
Chimeric retrovial expression vectors and particles containing a simple retroviral long terminal repeat, BLV or HIV coding regions and cis-acting regulatory sequences, and an RNA translational enhancer with internal ribsome entry site
|
|
EP0614989A1
(en)
|
1993-02-17 |
1994-09-14 |
MorphoSys AG |
A method for in vivo selection of ligand-binding proteins
|
|
CA2161351C
(en)
|
1993-04-26 |
2010-12-21 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5514670A
(en)
|
1993-08-13 |
1996-05-07 |
Pharmos Corporation |
Submicron emulsions for delivery of peptides
|
|
US5625825A
(en)
|
1993-10-21 |
1997-04-29 |
Lsi Logic Corporation |
Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
|
|
US5814599A
(en)
|
1995-08-04 |
1998-09-29 |
Massachusetts Insitiute Of Technology |
Transdermal delivery of encapsulated drugs
|
|
SE9304060D0
(sv)
|
1993-12-06 |
1993-12-06 |
Bioinvent Int Ab |
Sätt att selektera specifika bakteriofager
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
US5763733A
(en)
|
1994-10-13 |
1998-06-09 |
Enzon, Inc. |
Antigen-binding fusion proteins
|
|
US5549551A
(en)
|
1994-12-22 |
1996-08-27 |
Advanced Cardiovascular Systems, Inc. |
Adjustable length balloon catheter
|
|
US5656730A
(en)
|
1995-04-07 |
1997-08-12 |
Enzon, Inc. |
Stabilized monomeric protein compositions
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
US5730723A
(en)
|
1995-10-10 |
1998-03-24 |
Visionary Medical Products Corporation, Inc. |
Gas pressured needle-less injection device and method
|
|
GB9526100D0
(en)
|
1995-12-20 |
1996-02-21 |
Intersurgical Ltd |
Nebulizer
|
|
JP2000503565A
(ja)
|
1996-01-03 |
2000-03-28 |
グラクソ、グループ、リミテッド |
吸入装置
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
DE19624387C2
(de)
|
1996-06-19 |
1999-08-19 |
Hatz Motoren |
Kaltstartvorrichtung
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US5879681A
(en)
|
1997-02-07 |
1999-03-09 |
Emisphere Technolgies Inc. |
Compounds and compositions for delivering active agents
|
|
US5921447A
(en)
|
1997-02-13 |
1999-07-13 |
Glaxo Wellcome Inc. |
Flow-through metered aerosol dispensing apparatus and method of use thereof
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
IL120943A
(en)
|
1997-05-29 |
2004-03-28 |
Univ Ben Gurion |
A system for administering drugs through the skin
|
|
UA81743C2
(uk)
|
2000-08-07 |
2008-02-11 |
Центокор, Инк. |
МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
|
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
|
TWI334439B
(en)
|
2001-08-01 |
2010-12-11 |
Centocor Inc |
Anti-tnf antibodies, compositions, methods and uses
|
|
WO2003100013A2
(en)
|
2002-05-23 |
2003-12-04 |
Cognis Corporation |
NON-REVERTIBLE β-OXIDATION BLOCKED CANDIDA TROPICALIS
|
|
EP1789446A2
(en)
|
2004-09-02 |
2007-05-30 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
CN102961746B
(zh)
*
|
2005-05-16 |
2016-06-15 |
艾伯维生物技术有限公司 |
TNFα抑制剂治疗腐蚀性多关节炎的用途
|
|
DE102005028778A1
(de)
|
2005-06-22 |
2006-12-28 |
SUNJÜT Deutschland GmbH |
Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
JP5470817B2
(ja)
|
2008-03-10 |
2014-04-16 |
日産自動車株式会社 |
電池用電極およびこれを用いた電池、並びにその製造方法
|
|
JP2012525149A
(ja)
|
2009-04-27 |
2012-10-22 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
ヘテロ多量体分子を作製するための方法
|
|
JP5155355B2
(ja)
|
2010-04-07 |
2013-03-06 |
レノボ・シンガポール・プライベート・リミテッド |
無線基地局の自律的な負荷調整が可能な無線端末装置
|
|
DK2560993T3
(da)
|
2010-04-20 |
2024-10-14 |
Genmab As |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
|
PL2635607T3
(pl)
|
2010-11-05 |
2020-05-18 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
|
|
CA2854233C
(en)
|
2011-11-04 |
2020-05-12 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
JP6136279B2
(ja)
|
2013-01-15 |
2017-05-31 |
株式会社ジェイテクト |
転がり軸受装置
|
|
TWI503850B
(zh)
|
2013-03-22 |
2015-10-11 |
Polytronics Technology Corp |
過電流保護元件
|
|
TWI510996B
(zh)
|
2013-10-03 |
2015-12-01 |
Acer Inc |
控制觸控面板的方法以及使用該方法的可攜式電腦
|
|
US9816280B1
(en)
|
2016-11-02 |
2017-11-14 |
Matthew Reitnauer |
Portable floor
|
|
KR20190113858A
(ko)
*
|
2017-01-30 |
2019-10-08 |
얀센 바이오테크 인코포레이티드 |
활성 건선성 관절염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
|