JP2022535734A - 縮合複素環誘導体 - Google Patents

縮合複素環誘導体 Download PDF

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Publication number
JP2022535734A
JP2022535734A JP2021570274A JP2021570274A JP2022535734A JP 2022535734 A JP2022535734 A JP 2022535734A JP 2021570274 A JP2021570274 A JP 2021570274A JP 2021570274 A JP2021570274 A JP 2021570274A JP 2022535734 A JP2022535734 A JP 2022535734A
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JP
Japan
Prior art keywords
compound
alkyl
formula
mmol
hbv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021570274A
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English (en)
Japanese (ja)
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JPWO2020243135A5 (https=
JP2022535734A5 (https=
Inventor
グロッセ，サンドリーヌ，セリーヌ
ディラット，リンジー，グラハム
ファンダイク，コーン
ジャン－マリー バーナード ラボイソン，ピエール
マリア アロイシャス ピーター，セルジュ
ケステレイン，バート，ルドルフ，ロマニー
フェルシュ－レン，ウィム，ガストン
ベルク，ジャン，マーティン
チャールス アール． ルコント，モルガン
ラメンカ，キャロリーナ マルティネス
ヒューゴ マリア ヨンカー，ティム
デン，カン
チャン，イーミン
シュー，ヤンピン
チェン，チャンリン
フ－，リリ－
クデゥク，スコット，ディー
Original Assignee
ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=71741889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2022535734(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー filed Critical ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー
Publication of JP2022535734A publication Critical patent/JP2022535734A/ja
Publication of JPWO2020243135A5 publication Critical patent/JPWO2020243135A5/ja
Publication of JP2022535734A5 publication Critical patent/JP2022535734A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021570274A 2019-05-28 2020-05-27 縮合複素環誘導体 Pending JP2022535734A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962853533P 2019-05-28 2019-05-28
EP19176933.0 2019-05-28
US62/853,533 2019-05-28
EP19176933 2019-05-28
CNPCT/CN2020/085720 2020-04-20
CN2020085720 2020-04-20
PCT/US2020/034643 WO2020243135A1 (en) 2019-05-28 2020-05-27 Fused heterocyclic derivatives

Publications (3)

Publication Number Publication Date
JP2022535734A true JP2022535734A (ja) 2022-08-10
JPWO2020243135A5 JPWO2020243135A5 (https=) 2023-06-05
JP2022535734A5 JP2022535734A5 (https=) 2023-06-05

Family

ID=71741889

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021570274A Pending JP2022535734A (ja) 2019-05-28 2020-05-27 縮合複素環誘導体

Country Status (19)

Country Link
EP (1) EP3976617B1 (https=)
JP (1) JP2022535734A (https=)
KR (1) KR20220012913A (https=)
CN (1) CN113906028A (https=)
AU (1) AU2020285718A1 (https=)
BR (1) BR112021022889A8 (https=)
CA (1) CA3138168A1 (https=)
CL (1) CL2021003155A1 (https=)
CO (1) CO2021016433A2 (https=)
CR (1) CR20210666A (https=)
DO (1) DOP2021000230A (https=)
IL (1) IL288322A (https=)
JO (1) JOP20210313A1 (https=)
MA (1) MA56043A (https=)
MX (1) MX2021014575A (https=)
PE (1) PE20220767A1 (https=)
PH (1) PH12021552974A1 (https=)
SG (1) SG11202113167QA (https=)
WO (1) WO2020243135A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116744927A (zh) * 2020-12-02 2023-09-12 杨森科学爱尔兰无限公司 稠合杂环衍生物及其在治疗hbv感染中的用途
WO2022116999A1 (en) * 2020-12-02 2022-06-09 Janssen Sciences Ireland Unlimited Company Fused heterocyclic derivatives and their use in the treatment of hbv infection
WO2022116998A1 (en) * 2020-12-02 2022-06-09 Janssen Sciences Ireland Unlimited Company Fused heterocyclic derivatives as hbv inhibitors
WO2022253255A1 (en) * 2021-06-02 2022-12-08 Janssen Sciences Ireland Unlimited Company Fused heterocyclic derivatives
CN117715909A (zh) 2021-06-02 2024-03-15 杨森科学爱尔兰无限公司 稠合杂环衍生物
WO2024114709A1 (en) * 2022-12-01 2024-06-06 Janssen Sciences Ireland Unlimited Company A crystal form of a fused heterocycle derivative compound
WO2024140851A1 (zh) * 2022-12-28 2024-07-04 上海维申医药有限公司 一类Toll样受体抑制剂及其制备和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016038045A1 (en) * 2014-09-08 2016-03-17 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Pyrazolopyridine derivatives and their use in therapy
WO2018005883A1 (en) * 2016-06-29 2018-01-04 Novira Therapeutics, Inc. Diazepinone derivatives and their use in the treatment of hepatitis b infections
WO2018005881A1 (en) * 2016-06-29 2018-01-04 Novira Therapeutics, Inc. Oxadiazepinone derivatives and their use in the treatment of hepatitis b infections
WO2020221826A1 (en) * 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2742305C2 (ru) * 2014-12-30 2021-02-04 Новира Терапьютикс, Инк. Производные и способы лечения инфекций гепатита в

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016038045A1 (en) * 2014-09-08 2016-03-17 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Pyrazolopyridine derivatives and their use in therapy
WO2018005883A1 (en) * 2016-06-29 2018-01-04 Novira Therapeutics, Inc. Diazepinone derivatives and their use in the treatment of hepatitis b infections
WO2018005881A1 (en) * 2016-06-29 2018-01-04 Novira Therapeutics, Inc. Oxadiazepinone derivatives and their use in the treatment of hepatitis b infections
WO2020221826A1 (en) * 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)

Also Published As

Publication number Publication date
WO2020243135A1 (en) 2020-12-03
EP3976617B1 (en) 2025-04-23
BR112021022889A2 (pt) 2022-01-04
PE20220767A1 (es) 2022-05-16
CR20210666A (es) 2022-03-11
PH12021552974A1 (en) 2022-07-11
DOP2021000230A (es) 2022-05-31
EP3976617A1 (en) 2022-04-06
CA3138168A1 (en) 2020-12-03
CO2021016433A2 (es) 2021-12-10
BR112021022889A8 (pt) 2024-03-05
CL2021003155A1 (es) 2022-07-22
MA56043A (fr) 2022-04-06
MX2021014575A (es) 2022-05-24
CN113906028A (zh) 2022-01-07
JOP20210313A1 (ar) 2021-11-25
SG11202113167QA (en) 2021-12-30
AU2020285718A1 (en) 2022-02-03
IL288322A (en) 2022-01-01
KR20220012913A (ko) 2022-02-04

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