JP2022534778A5 - - Google Patents

Info

Publication number
JP2022534778A5
JP2022534778A5 JP2021571518A JP2021571518A JP2022534778A5 JP 2022534778 A5 JP2022534778 A5 JP 2022534778A5 JP 2021571518 A JP2021571518 A JP 2021571518A JP 2021571518 A JP2021571518 A JP 2021571518A JP 2022534778 A5 JP2022534778 A5 JP 2022534778A5
Authority
JP
Japan
Prior art keywords
patient
cells
derived
microorganospheres
tissue sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021571518A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022534778A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/026275 external-priority patent/WO2020242594A1/en
Publication of JP2022534778A publication Critical patent/JP2022534778A/ja
Publication of JP2022534778A5 publication Critical patent/JP2022534778A5/ja
Pending legal-status Critical Current

Links

JP2021571518A 2019-05-28 2020-04-01 患者由来ミクロオルガノスフェアのための方法及び装置 Pending JP2022534778A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962853219P 2019-05-28 2019-05-28
US62/853,219 2019-05-28
PCT/US2020/026275 WO2020242594A1 (en) 2019-05-28 2020-04-01 Methods and apparatuses for patient-derived micro-organospheres

Publications (2)

Publication Number Publication Date
JP2022534778A JP2022534778A (ja) 2022-08-03
JP2022534778A5 true JP2022534778A5 (enExample) 2023-04-07

Family

ID=73549270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021571518A Pending JP2022534778A (ja) 2019-05-28 2020-04-01 患者由来ミクロオルガノスフェアのための方法及び装置

Country Status (10)

Country Link
US (2) US11555180B2 (enExample)
EP (1) EP3976064A4 (enExample)
JP (1) JP2022534778A (enExample)
CN (1) CN116157134A (enExample)
AU (1) AU2020283390A1 (enExample)
CA (1) CA3142113A1 (enExample)
IL (1) IL288370A (enExample)
MX (1) MX2021014439A (enExample)
SG (1) SG11202113122SA (enExample)
WO (1) WO2020242594A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114410466A (zh) * 2020-04-01 2022-04-29 沈西凌 用于个性化癌症治疗的精确药物筛选
WO2022115455A1 (en) * 2020-11-24 2022-06-02 Duke University Droplet organoid-based immuno-oncology assays and methods of using same
DE102022100146B4 (de) 2022-01-04 2023-11-30 Precomb Therapeutics Ag Verfahren zur analyse von personalisierten anti-krebs-wirkstoffen in zellkulturen
JP2025514291A (ja) * 2022-04-29 2025-05-02 ザイリス, インク. マイクロオルガノスフェアを使用して肝細胞毒性を試験するための方法及び装置
EP4519686A4 (en) * 2022-05-03 2026-05-06 Xilis Inc Patient-Derived Microorganospheres (MOS) Enabling Clinical Precision Oncology
WO2024039770A2 (en) * 2022-08-17 2024-02-22 Xilis, Inc. Imaging-based microorganosphere drug assays
JP2025532497A (ja) * 2022-09-07 2025-10-01 ザイリス, インク. 多発性骨髄腫MicroOrganoSphere
EP4601758A1 (en) 2022-10-11 2025-08-20 Xilis, Inc. Integrated microfluidic system for generation of microorganospheres (mos)

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
PT671923E (pt) 1992-10-09 2001-10-30 Advanced Tissue Sciences Inc Celulas de reserva do figado
WO2005047863A2 (en) 2003-11-10 2005-05-26 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
US7759111B2 (en) * 2004-08-27 2010-07-20 The Regents Of The University Of California Cell encapsulation microfluidic device
WO2006078814A2 (en) 2005-01-20 2006-07-27 The Regents Of The University Of California Cellular microarrays for screening differentiation factors
US20070134209A1 (en) * 2005-12-12 2007-06-14 Metafluidics, Inc. Cellular encapsulation for self-assembly of engineered tissue
US20120135875A1 (en) * 2008-02-29 2012-05-31 Bristol-Myers Squibb Company Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
CN103635587A (zh) 2008-04-08 2014-03-12 麻省理工学院 三维微流平台和其使用方法
WO2012018982A2 (en) * 2010-08-05 2012-02-09 Tufts Medical Center, Inc. Methods and kits for modulating tumor invasiveness and metastatic potential
GB201105226D0 (en) * 2011-03-29 2011-05-11 Univ Leiden Methods
SG10201805199RA (en) * 2011-06-02 2018-07-30 Harvard College Methods and Uses for Ex Vivo Tissue Culture Systems
US9334473B2 (en) 2012-08-17 2016-05-10 Jelena Vukasinovic Three dimensional cell culture compositions and methods of use
WO2014082096A1 (en) * 2012-11-26 2014-05-30 The Trustees Of Columbia University In The City Of New York Method for culture of human and mouse prostate organoids and uses thereof
KR102257305B1 (ko) 2013-03-28 2021-05-28 더 유니버시티 오브 브리티쉬 콜롬비아 미세유동 장치 및 분비물의 다세포 검정법에서의 그의 사용 방법
AU2014275006A1 (en) * 2013-06-04 2015-12-24 University Of Miami Assays, methods and kits for analyzing sensitivity and resistance to anti-cancer drugs, predicting a cancer patient's prognosis, and personalized treatment strategies
WO2015027086A1 (en) 2013-08-21 2015-02-26 University Of Louisville Research Foundation, Inc. Methods of making spheroids including biologically-relevant materials
US10928382B2 (en) * 2014-06-26 2021-02-23 Northeastern University Microfluidic device and method for analysis of tumor cell microenvironments
EP3242930A4 (en) 2015-01-07 2019-01-16 Dana-Farber Cancer Institute, Inc. MICROFLUIDIC CELL CULTURE OF TUMOR CELL SPHEROIDS FROM PATIENTS
WO2016145242A1 (en) * 2015-03-11 2016-09-15 Agenus Inc. Methods and compositions for high throughput screening of biomolecules using gel microdrops
AU2016346332B2 (en) * 2015-10-26 2022-03-03 University Of Wyoming Methods of generating microparticles and porous hydrogels using microfluidics
TWM516858U (zh) 2015-11-19 2016-02-11 金鼎聯合科技纖維股份有限公司 膠線改良結構
GB2564582B (en) 2016-02-01 2021-09-22 Emulate Inc Systems and methods for growth of intestinal cells in microfluidic devices
JP6967535B2 (ja) * 2016-06-15 2021-11-17 ミメタス ビー.ブイ. 細胞培養装置及び方法
EP3484487A4 (en) * 2016-07-12 2020-06-17 The University of North Carolina at Chapel Hill BIOMATRIX SCALES FOR USE IN THE DIAGNOSIS AND MODELING OF CANCER
US11180735B2 (en) * 2016-10-28 2021-11-23 The Board Of Trustees Of The Leland Stanford Junior University Methods to preserve tumor-stromal interactions in culture and therapeutic predictive applications thereof
CN110997900B (zh) * 2017-07-14 2024-06-14 多伦多大学管理委员会 用于快速产生用于化合物筛选的类器官/球状体的微流体平台
WO2019067795A1 (en) 2017-09-27 2019-04-04 Duke University PATIENT-SPECIFIC CLINICAL TRIALS AND METHODS OF TREATMENT THEREOF
US11166920B2 (en) * 2017-10-05 2021-11-09 Auburn University Microfluidics device for fabrication of large, uniform, injectable hydrogel microparticles for cell encapsulation
WO2019111998A1 (ja) * 2017-12-08 2019-06-13 京ダイアグノスティクス株式会社 癌スフェロイドの製造方法および大腸癌患者の選択方法
GB201721615D0 (en) * 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
CN110004111B (zh) * 2019-04-22 2021-10-08 清华-伯克利深圳学院筹备办公室 一种类器官球体的制备方法

Similar Documents

Publication Publication Date Title
Xue et al. Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance
JP2022095914A (ja) 操作した肝臓組織、そのアレイ、およびそれを製造する方法
KR101282926B1 (ko) 표면장력을 이용한 반구형 마이크로웰의 제조 및 이를 이용한 세포 집합체의 형성
Kobayashi et al. Preparation of stripe-patterned heterogeneous hydrogel sheets using microfluidic devices for high-density coculture of hepatocytes and fibroblasts
Pampaloni et al. Three-dimensional tissue models for drug discovery and toxicology
Tan et al. Human fibroblast-macrophage tissue spheroids demonstrate ratio-dependent fibrotic activity for in vitro fibrogenesis model development
JP2017518070A5 (enExample)
JP2018171065A (ja) インビトロでの研究使用のための操作した組織、そのアレイ、およびその製造方法
Zhang et al. Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective
Chowdhury et al. Circulating tumor cells in cancer diagnostics and prognostics by single-molecule and single-cell characterization
US20230077412A1 (en) 3d printed micro-millifluidic bioreactors for long-term retinal organoid maintenance
Zhang et al. Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment
CN104164360B (zh) 集成微流控芯片及其用于三维肿瘤定位、构建、回收方法
Handro et al. A histological study of the development of buds, roots, and embryos in organ cultures of Petunia inflata R. Fries
JP2023554171A5 (enExample)
Southworth et al. Freeze-etched pollen walls of Artemisia pycnocephala and Lilium humboldtii
Chambers et al. Scanning electron microscopy of Tilia pollen
CN114958755A (zh) 一种分级富集癌细胞及类器官的方法、装置
Sun et al. Application of three-dimensional cell culture technology in screening anticancer drugs
CN105695392B (zh) 一种可提高肝细胞体外分化表型及功能的培养方法
CN115678778A (zh) 一种培养三维细胞团的微流控芯片装置
Argue The pollen of Limnocharis flava Buch., Hydrocleis nymphoides (Willd.) Buch., and Tenagocharis latifolia (Don) Buch.(Limnocharitaceae)
Feldman et al. Nuclear changes associated with cellular dedifferentiation in pea root cortical cells cultured in vitro
CN111139220B (zh) 脐带间充质干细胞的三维培养方法
Chen et al. Massive fabrication of functional hepatic cancer spheroids by micropatterned GelMA hydrogel chip for drug screening