JP2022532134A5 - - Google Patents
Info
- Publication number
- JP2022532134A5 JP2022532134A5 JP2021566259A JP2021566259A JP2022532134A5 JP 2022532134 A5 JP2022532134 A5 JP 2022532134A5 JP 2021566259 A JP2021566259 A JP 2021566259A JP 2021566259 A JP2021566259 A JP 2021566259A JP 2022532134 A5 JP2022532134 A5 JP 2022532134A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- referred
- peptide ligand
- cysteine residues
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962845473P | 2019-05-09 | 2019-05-09 | |
| US62/845,473 | 2019-05-09 | ||
| PCT/GB2020/051144 WO2020225577A1 (en) | 2019-05-09 | 2020-05-11 | Bicyclic peptide ligands specific for ox40 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022532134A JP2022532134A (ja) | 2022-07-13 |
| JP2022532134A5 true JP2022532134A5 (https=) | 2023-05-17 |
Family
ID=70847426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021566259A Pending JP2022532134A (ja) | 2019-05-09 | 2020-05-11 | Ｏｘ４０に特異的な二環式ペプチドリガンド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11613560B2 (https=) |
| EP (1) | EP3965827A1 (https=) |
| JP (1) | JP2022532134A (https=) |
| KR (1) | KR20220007098A (https=) |
| CN (1) | CN113811541A (https=) |
| AU (1) | AU2020269506A1 (https=) |
| BR (1) | BR112021022315A2 (https=) |
| CA (1) | CA3137095A1 (https=) |
| IL (1) | IL287881A (https=) |
| MX (1) | MX2021013669A (https=) |
| SG (1) | SG11202111606TA (https=) |
| WO (1) | WO2020225577A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| WO2020128527A1 (en) | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| WO2020225577A1 (en) | 2019-05-09 | 2020-11-12 | Bicycletx Limited | Bicyclic peptide ligands specific for ox40 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| SMT202500247T1 (it) * | 2019-10-03 | 2025-09-12 | Bicycletx Ltd | Complessi peptidici eterotandem biciclici |
| AU2021322934A1 (en) | 2020-08-03 | 2023-03-30 | Bicycletx Limited | Peptide-based linkers |
| AU2022206577A1 (en) * | 2021-01-08 | 2023-08-24 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| MX2024003876A (es) * | 2021-09-29 | 2024-04-19 | Conjustar Zhuhai Biologics Co Ltd | Conjugado farmaco-polipeptido triciclico y sus aplicaciones. |
| CN114933638B (zh) * | 2022-05-12 | 2024-07-26 | 厦门大学 | 特异性靶向cd28的多元环肽配体框架 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927203B1 (en) | 1999-08-17 | 2005-08-09 | Purdue Research Foundation | Treatment of metastatic disease |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| EP2653545A1 (en) | 2008-02-05 | 2013-10-23 | Bicycle Therapeutics Limited | Methods and compositions |
| GB0913775D0 (en) | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| WO2012057624A1 (en) | 2010-10-25 | 2012-05-03 | Pepscan Systems B.V. | Novel bicyclic peptide mimetics |
| WO2013119202A1 (en) * | 2012-02-06 | 2013-08-15 | Providence Health & Services - Oregon | Cancer treatment and monitoring methods using ox40 agonists |
| US9868767B2 (en) | 2013-05-23 | 2018-01-16 | Ohio State Innovation Foundation | Chemical synthesis and screening of bicyclic peptide libraries |
| JP6807831B2 (ja) | 2014-05-21 | 2021-01-06 | エントラーダ セラピューティクス，インコーポレイテッド | 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法 |
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| US10786547B2 (en) * | 2015-07-16 | 2020-09-29 | Biokine Therapeutics Ltd. | Compositions, articles of manufacture and methods for treating cancer |
| JP2019513371A (ja) | 2016-04-01 | 2019-05-30 | アビディティー バイオサイエンシーズ エルエルシー | 核酸ポリペプチド組成物とその使用 |
| EP3445788B1 (en) | 2016-04-22 | 2022-01-19 | Alligator Bioscience AB | Novel bispecific polypeptides against cd137 |
| GB201607827D0 (en) * | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| WO2018115203A1 (en) | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| AU2018224094B2 (en) | 2017-02-24 | 2025-04-17 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| EP3774851A1 (en) | 2018-04-04 | 2021-02-17 | BicycleTX Limited | Heterotandem bicyclic peptide complexes |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| SG11202110828UA (en) | 2019-04-02 | 2021-10-28 | Bicycletx Ltd | Bicycle toxin conjugates and uses thereof |
| WO2020225577A1 (en) | 2019-05-09 | 2020-11-12 | Bicycletx Limited | Bicyclic peptide ligands specific for ox40 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| SMT202500247T1 (it) | 2019-10-03 | 2025-09-12 | Bicycletx Ltd | Complessi peptidici eterotandem biciclici |
| MX2022006001A (es) | 2019-11-27 | 2022-10-27 | Bicycletx Ltd | Ligandos de peptidos biciclicos especificos para el receptor 2 tipo a de efrina (epha2) y usos de los mismos. |
| CN115698720A (zh) | 2020-06-12 | 2023-02-03 | 拜斯科技术开发有限公司 | 特征在于促红细胞生成素产生肝细胞受体a2(epha2)的过表达的疾病的治疗 |
-
2020
- 2020-05-11 WO PCT/GB2020/051144 patent/WO2020225577A1/en not_active Ceased
- 2020-05-11 MX MX2021013669A patent/MX2021013669A/es unknown
- 2020-05-11 EP EP20728128.8A patent/EP3965827A1/en not_active Withdrawn
- 2020-05-11 CA CA3137095A patent/CA3137095A1/en active Pending
- 2020-05-11 BR BR112021022315A patent/BR112021022315A2/pt not_active IP Right Cessation
- 2020-05-11 JP JP2021566259A patent/JP2022532134A/ja active Pending
- 2020-05-11 CN CN202080033959.9A patent/CN113811541A/zh active Pending
- 2020-05-11 SG SG11202111606TA patent/SG11202111606TA/en unknown
- 2020-05-11 AU AU2020269506A patent/AU2020269506A1/en not_active Abandoned
- 2020-05-11 US US16/872,097 patent/US11613560B2/en active Active
- 2020-05-11 KR KR1020217039675A patent/KR20220007098A/ko not_active Ceased
-
2021
- 2021-11-07 IL IL287881A patent/IL287881A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022532134A5 (https=) | ||
| JP2022514687A5 (https=) | ||
| AU2020378282B2 (en) | Dual IL-2R and IL-7R binding compounds | |
| JP7427286B2 (ja) | ＩＬ－２ＲβγＣ結合化合物 | |
| TWI812918B (zh) | IL-7Rαγc結合化合物 | |
| CA3101427A1 (en) | Bicyclic peptide ligands specific for nectin-4 | |
| JP2022514255A5 (https=) | ||
| JP2022517040A5 (https=) | ||
| JP2022518695A5 (https=) | ||
| JP2022512478A5 (https=) | ||
| JP2022518210A5 (https=) | ||
| JP2022513223A5 (https=) | ||
| CN108368511B (zh) | 单链cd137受体激动剂蛋白 | |
| JP2022515720A5 (https=) | ||
| EP4268901A2 (en) | Il-2r beta-gamma c binding compounds and uses thereof | |
| US20220119492A1 (en) | Il-2r-beta-gamma binding compounds and uses thereof | |
| JP2023524995A5 (https=) | ||
| JP2020537690A (ja) | プレクチン１結合抗体およびその使用 | |
| JP2023520714A5 (https=) | ||
| JP2022515721A5 (https=) | ||
| EP4701738A1 (en) | Bispecific fusion proteins with immunosuppressive activity | |
| IL256261A (en) | Compounds and method for hide1 |