JP2022531954A - 4つの日焼け止め物質からなる光防護システム - Google Patents
4つの日焼け止め物質からなる光防護システム Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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Abstract
Description
(a)5,6,5',6'-テトラフェニル-3,3'-(1,4-フェニレン)-ビス[1,2,4]トリアジン、
(b)2,4-ビス[4-(2-エチルヘキシルオキシ)-2-ヒドロキシフェニル]-6-(4-メトキシフェニル)-1,3,5-トリアジン、
(c)ヘキシル2-[4-(ジエチルアミノ)-2-ヒドロキシベンゾイル]ベンゾエート、および
(d)エチルヘキシルトリアゾン、ジエチルヘキシルブタミドトリアゾンおよび2-エチルヘキシルサリシレートからなる群から選択される日射フィルター
からなる光防護システム、
を含む、化粧品組成物または医薬組成物であって、
該光防護システムは、組成物の総重量に対して組成物の4重量%~20重量%を示し、
該光防護システムを構成するもの以外のいかなる日射フィルターも含まない化粧品組成物または医薬組成物に関する。
-狭義のフィルターであって、これは主に照射を吸収する、および
-スクリーンであって、これは照射を吸収および反射する。
(a)5,6,5',6'-テトラフェニル-3,3'-(1,4-フェニレン)-ビス[1,2,4]トリアジン(CAS n°:55514-22-2)、これは、フェニレンビス-ジフェニルトリアジンとも称される。
Diはサイズクラスである]
で定義される。
(a)5,6,5',6'-テトラフェニル-3,3'-(1,4-フェニレン)-ビス[1,2,4]トリアジン、
(b)2,4-ビス[4-(2-エチルヘキシルオキシ)-2-ヒドロキシフェニル]-6-(4-メトキシフェニル)-1,3,5-トリアジン、
(c)ヘキシル2-[4-(ジエチルアミノ)-2-ヒドロキシベンゾイル]ベンゾエート、および
(d)エチルヘキシルトリアゾン、からなる光防護システムを含み、
該光防護システムは、組成物の総重量に対して組成物の4重量%~20重量%、例えば6重量%~19重量%、とりわけ7重量%~18重量%、特に8重量%~17重量%、有利には14重量%~17重量%、典型的には15重量%~16重量%を示し、
そして、該光防護システムを構成するもの以外のいかなる日射フィルターも含まない。
以下の処方において、5,6,5',6'-テトラフェニル-3,3'-(1,4-フェニレン)-ビス[1,2,4]トリアジンは、45重量%(w/w)の活性物質を含む水性分散液の形態であり、150~250nmのD50を特徴とする。
フェニレンビス-ジフェニルトリアジン粒子のD50は、湿式法によって、マスターサイザ3000レーザー回折粒度計を用いて測定する。
本発明による組成物によって提供される光防護を定量化するためのパラメーターは、2011年3月に発行されたガイドラインにおいてCOLIPA(欧州化粧品および香水協会、European Cosmetic and Perfumery Association)によって推奨された方法に従って評価する。
-UV分光光度計
分光光度計により、その表面に日焼け止め組成物の層がある場合とない場合のプレートを通過するスペクトル透過率を測定する。
プレートとは、日焼け止め組成物が適用される材料である。この材料は、UVに対して透明であり、非蛍光性であり、光安定性があり、試験する組成物の化合物に対して不活性でなければならない。このプロトコルにおいて、PMMAプレートが理想的であることが証明されている。
UV源は、可視+UVA+UVBのスペクトルを拡散するキセノンアークランプを搭載した日射シミュレーターである。この研究で使用したUV源は、Suntest CPS+(Atlas)である。
-未処理のプレートを通過する透過率の測定
まず、対照プレートを通過するUV透過率を測定する必要がある。これは、数マイクロリットルのグリセリンをプレートの表面が完全に覆われるように塗り付けて準備する。
試験する試料を、1.3mg/cm2の量(プレートに残っている実際の量)でPMMAプレートに適用する。量の正確さおよび結果の再現性を保証するために、適用ゾーンは10cm2より大きくする。
試料で処理したプレートを分光光度計で分析し、試料を通過するUV照射透過率の平均値を、290nmから400nmまでの波長ごとに測定する(プレートの様々な領域で測定した単色吸光度データを使用する)。
各試料について、少なくとも3つのPMMAプレートを用意する必要がある。各プレートは、実際上、ほぼ全面が分光測光法によって測定されない限り、少なくとも9つの異なる領域で測定する必要がある。
これは、次の式に従って、5および10MEDの照射量で照射する前後の吸光度データA(λ)から作成する:
S(λ)は、日射スペクトルの照射量(irradiance)に相当し、
A(λ)は、試料の吸光度に相当し、
dλは、波長変動(1nm)である]。
この試験は、再構成ヒト角膜上皮を用いて眼刺激性の可能性を評価するための動物実験の代替方法である。
この試験は、眼刺激性の可能性を評価するための動物実験の代替方法である。
Claims (12)
- 少なくとも1つの化粧学的にまたは薬学的に許容される賦形剤、ならびに
(a)5,6,5',6'-テトラフェニル-3,3'-(1,4-フェニレン)-ビス[1,2,4]トリアジン、
(b)2,4-ビス[4-(2-エチルヘキシルオキシ)-2-ヒドロキシフェニル]-6-(4-メトキシフェニル)-1,3,5-トリアジン、
(c)ヘキシル2-[4-(ジエチルアミノ)-2-ヒドロキシベンゾイル]ベンゾエート、および
(d)エチルヘキシルトリアゾン、ジエチルヘキシルブタミドトリアゾンおよび2-エチルヘキシルサリシレートからなる群から選択される日射フィルター
からなる光防護システム、
を含む、化粧品組成物または医薬組成物であって、
該光防護システムは、組成物の総重量に対して組成物の4重量%~20重量%、特に6重量%~19重量%、とりわけ7重量%~18重量%、典型的には8重量%~17重量%を示すことを特徴とする、該光防護システムを構成するもの以外のいかなる日射フィルターも含まない化粧品組成物または医薬組成物。 - 5,6,5',6'-テトラフェニル-3,3'-(1,4-フェニレン)-ビス[1,2,4]トリアジンが、組成物の総重量に対して組成物の1重量%~5重量%、とりわけ2重量%~5重量%、特に2重量%~4重量%、典型的には3重量%~4重量%を示すことを特徴とする、請求項1に記載の組成物。
- 2,4-ビス[4-(2-エチルヘキシルオキシ)-2-ヒドロキシフェニル]-6-(4-メトキシフェニル)-1,3,5-トリアジンが、組成物の総重量に対して組成物の1重量%~4重量%、特に2重量%~3重量%を示すことを特徴とする、請求項1または2に記載の組成物。
- ヘキシル2-[4-(ジエチルアミノ)-2-ヒドロキシベンゾイル]ベンゾエートが、組成物の総重量に対して組成物の1重量%~10重量%、とりわけ3重量%~10重量%、特に4重量%~9重量%、典型的には5重量%~8重量%、例えば5重量%~6重量%を示すことを特徴とする、請求項1~3のいずれか一項に記載の組成物。
- 日射フィルター(d)が、組成物の総重量に対して組成物の1重量%~5重量%、とりわけ2重量%~4重量%、特に3重量%~4重量%を示すことを特徴とする、請求項1~4のいずれか一項に記載の組成物。
- 日射フィルター(d)が、エチルヘキシルトリアゾンであることを特徴とする、請求項1~5のいずれか一項に記載の組成物。
- 5,6,5',6'-テトラフェニル-3,3'-(1,4-フェニレン)-ビス[1,2,4]トリアジン粒子のサイズD50が100~1000nmに含まれることを特徴とする、請求項1~6のいずれか一項に記載の組成物。
- C12-C15アルキルベンゾエート、ジカプリルイルカーボネートおよびカプリル酸/カプリン酸トリグリセリドを含むことを特徴とする、請求項1~7のいずれか一項に記載の組成物。
- エタノールおよびイソプロパノールを含まないことを特徴とする、請求項1~8のいずれか一項に記載の組成物。
- エマルジョン形態であることを特徴とする、請求項1~9のいずれか一項に記載の組成物。
- SPFが、50またはそれ以上、好ましくは60またはそれ以上であることを特徴とする、請求項1~10のいずれか一項に記載の組成物。
- SPF/UVA比が、3またはそれ以下であることを特徴とする、請求項11に記載の組成物。
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