JP2022530678A - 短縮センス鎖を有する二本鎖核酸阻害剤分子 - Google Patents

短縮センス鎖を有する二本鎖核酸阻害剤分子 Download PDF

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JP2022530678A
JP2022530678A JP2021564975A JP2021564975A JP2022530678A JP 2022530678 A JP2022530678 A JP 2022530678A JP 2021564975 A JP2021564975 A JP 2021564975A JP 2021564975 A JP2021564975 A JP 2021564975A JP 2022530678 A JP2022530678 A JP 2022530678A
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nucleotides
double
nucleic acid
strand
nucleotide
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JP2022530678A5 (enExample
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ボブ デール ブラウン
ウェイミン ワン
ネイム ナゼフ
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Dicerna Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content

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JP2021564975A 2019-05-03 2020-04-29 短縮センス鎖を有する二本鎖核酸阻害剤分子 Withdrawn JP2022530678A (ja)

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US201962842908P 2019-05-03 2019-05-03
US62/842,908 2019-05-03
PCT/US2020/030398 WO2020226960A1 (en) 2019-05-03 2020-04-29 Double-stranded nucleic acid inhibitor molecules with shortened sense strands

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JP2022530678A true JP2022530678A (ja) 2022-06-30
JP2022530678A5 JP2022530678A5 (enExample) 2023-05-10

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US (1) US12529053B2 (enExample)
EP (1) EP3963072A1 (enExample)
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KR (1) KR20220004675A (enExample)
CN (1) CN113795581A (enExample)
AU (1) AU2020268798A1 (enExample)
BR (1) BR112021021686A2 (enExample)
CA (1) CA3136676A1 (enExample)
CL (1) CL2021002842A1 (enExample)
IL (1) IL287354A (enExample)
MX (1) MX2021013418A (enExample)
SG (1) SG11202111077RA (enExample)
WO (1) WO2020226960A1 (enExample)

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HRP20240586T1 (hr) 2018-10-09 2024-07-19 The University Of British Columbia Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima
WO2023081500A2 (en) * 2021-11-08 2023-05-11 Dicerna Pharmaceuticals, Inc. RNAi OLIGONUCLEOTIDE CONJUGATES
WO2023207615A1 (zh) * 2022-04-26 2023-11-02 南京明德新药研发有限公司 一类含由天然核苷酸组成突出端的双链RNAi化合物

Citations (7)

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Publication number Priority date Publication date Assignee Title
JP2006516191A (ja) * 2002-11-21 2006-06-29 ワイス ループス腎炎の治療用組成物および方法
JP2010532872A (ja) * 2007-07-06 2010-10-14 プロメディオール， インコーポレイテッド 線維化関連障害のための治療および診断方法
JP2012500389A (ja) * 2008-08-12 2012-01-05 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法
JP2012504389A (ja) * 2008-09-22 2012-02-23 ダイセルナ ファーマシューティカルズ， インコーポレイテッド 修飾を有するｄｓＲＮＡによる遺伝子発現の特異的な阻害のための組成物および方法
WO2018045317A1 (en) * 2016-09-02 2018-03-08 Dicerna Pharmaceuticals, Inc. 4'-phosphate analogs and oligonucleotides comprising the same
WO2019136157A2 (en) * 2018-01-05 2019-07-11 Dicerna Pharmaceuticals, Inc. Reducing beta-catenin and ido expression to potentiate immunotherapy
WO2019200124A1 (en) * 2018-04-13 2019-10-17 Dicerna Pharmaceuticals, Inc. Double-stranded nucleic acid inhibitor molecules modified with tm-increasing nucleotides

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