JP2022529943A - がんの処置における使用のための、標的指向性のマスクされたｉ型インターフェロン（ｉｆｎａおよびｉｆｎｂ）と腫瘍抗原に対する抗体とを含む融合タンパク質組成物 - Google Patents

がんの処置における使用のための、標的指向性のマスクされたｉ型インターフェロン（ｉｆｎａおよびｉｆｎｂ）と腫瘍抗原に対する抗体とを含む融合タンパク質組成物 Download PDF

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JP2022529943A
JP2022529943A JP2021561663A JP2021561663A JP2022529943A JP 2022529943 A JP2022529943 A JP 2022529943A JP 2021561663 A JP2021561663 A JP 2021561663A JP 2021561663 A JP2021561663 A JP 2021561663A JP 2022529943 A JP2022529943 A JP 2022529943A
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ifn
antibody
tumor
masked
interferon
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デイビッド ストーバー
シェリー モリソン
アレックス バスササワット
カーム トリン
ジョージ アユーブ
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クウィクセル セラピューティクス リミテッド ライアビリティ カンパニー
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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JP2021561663A 2019-04-15 2020-04-15 がんの処置における使用のための、標的指向性のマスクされたｉ型インターフェロン（ｉｆｎａおよびｉｆｎｂ）と腫瘍抗原に対する抗体とを含む融合タンパク質組成物 Pending JP2022529943A (ja)

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JP2025032100A JP2025084914A (ja) 2019-04-15 2025-02-28 がんの処置における使用のための、標的指向性のマスクされたｉ型インターフェロン（ｉｆｎａおよびｉｆｎｂ）と腫瘍抗原に対する抗体とを含む融合タンパク質組成物

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US201962920140P 2019-04-15 2019-04-15
US62/920,140 2019-04-15
PCT/US2020/028296 WO2020214690A1 (en) 2019-04-15 2020-04-15 Fusion protein composition(s) comprising targeted masked type i interferons (ifna and ifnb) and an antibody against tumor antigen, for use in the treatment of cancer

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JP2021561663A Pending JP2022529943A (ja) 2019-04-15 2020-04-15 がんの処置における使用のための、標的指向性のマスクされたｉ型インターフェロン（ｉｆｎａおよびｉｆｎｂ）と腫瘍抗原に対する抗体とを含む融合タンパク質組成物
JP2025032100A Pending JP2025084914A (ja) 2019-04-15 2025-02-28 がんの処置における使用のための、標的指向性のマスクされたｉ型インターフェロン（ｉｆｎａおよびｉｆｎｂ）と腫瘍抗原に対する抗体とを含む融合タンパク質組成物

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AU2010215761B2 (en) * 2009-02-23 2017-04-06 Cytomx Therapeutics, Inc Proproteins and methods of use thereof
WO2020023702A1 (en) 2018-07-25 2020-01-30 AskGene Pharma, Inc. Novel il-21 prodrugs and methods of use thereof
CA3141626A1 (en) 2019-06-12 2020-12-17 AskGene Pharma, Inc. Novel il-15 prodrugs and methods of use thereof
CA3165927A1 (en) 2020-01-11 2021-07-15 AskGene Pharma, Inc. Novel masked cytokines and methods of use thereof
WO2021207669A1 (en) 2020-04-10 2021-10-14 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
IL298136A (en) 2020-05-13 2023-01-01 Bonum Therapeutics Inc Preparations of protein complexes and methods of using them
US20240076355A1 (en) * 2021-01-14 2024-03-07 AskGene Pharma, Inc. Interferon Prodrugs and Methods of Making and Using the Same
BR112023018735A2 (pt) 2021-03-16 2023-11-28 Cytomx Therapeutics Inc Construtos de citocinas ativáveis mascarados e composições e métodos relacionados
CA3221878A1 (en) 2021-06-18 2022-12-22 David Stover Fusion protein composition(s) comprising masked type i interferons (ifna and ifnb) for use in the treatment of cancer and methods thereof
CN118647629A (zh) * 2021-09-28 2024-09-13 苏州格治生物科技有限公司 含有TNF-α的免疫缀合物及其相关方法和组合物
CN115057946B (zh) * 2022-06-30 2023-05-16 四川省医学科学院·四川省人民医院 干扰素在制备抗广谱流感病毒和冠状病毒药物中的应用
TW202502388A (zh) 2023-03-02 2025-01-16 日商大鵬藥品工業股份有限公司 包含抗cd138抗體之抗體藥物複合體
WO2025201363A1 (zh) * 2024-03-27 2025-10-02 高雄医学大学 细胞因子阻断抗体及其应用

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JP2015509952A (ja) * 2012-02-28 2015-04-02 ザ ユニバーシティ オブ バーミンガム 免疫療法分子および使用
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