JP2022528696A - アンチコドンループを延長した合成転移ｒｎａ - Google Patents

アンチコドンループを延長した合成転移ｒｎａ Download PDF

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JP2022528696A
JP2022528696A JP2021559312A JP2021559312A JP2022528696A JP 2022528696 A JP2022528696 A JP 2022528696A JP 2021559312 A JP2021559312 A JP 2021559312A JP 2021559312 A JP2021559312 A JP 2021559312A JP 2022528696 A JP2022528696 A JP 2022528696A
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seq
trna
anticodon
nucleotide
transfer rna
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JP2022528696A5 (https=
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イグナトヴァ、ゾヤ
トルダ、アンドリュー
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アークタラス テラピュウティクス、インク
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Priority claimed from LU101182A external-priority patent/LU101182B1/en
Application filed by アークタラス テラピュウティクス、インク filed Critical アークタラス テラピュウティクス、インク
Publication of JP2022528696A publication Critical patent/JP2022528696A/ja
Publication of JP2022528696A5 publication Critical patent/JP2022528696A5/ja
Priority to JP2025092679A priority Critical patent/JP2025131687A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021559312A 2019-04-11 2020-04-09 アンチコドンループを延長した合成転移ｒｎａ Pending JP2022528696A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025092679A JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102019109664.2 2019-04-11
DE102019109664 2019-04-11
LULU101182 2019-04-11
LU101182A LU101182B1 (en) 2019-04-11 2019-04-11 Synthetic transfer RNA with extended anticodon loop
PCT/EP2020/060217 WO2020208169A1 (en) 2019-04-11 2020-04-09 Synthetic transfer rna with extended anticodon loop

Related Child Applications (1)

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JP2025092679A Division JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

Publications (2)

Publication Number Publication Date
JP2022528696A true JP2022528696A (ja) 2022-06-15
JP2022528696A5 JP2022528696A5 (https=) 2023-04-06

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JP2021559312A Pending JP2022528696A (ja) 2019-04-11 2020-04-09 アンチコドンループを延長した合成転移ｒｎａ
JP2025092679A Pending JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

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JP2025092679A Pending JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

Country Status (6)

Country Link
US (1) US20220162612A1 (https=)
EP (1) EP3953469A1 (https=)
JP (2) JP2022528696A (https=)
AU (1) AU2020273255B2 (https=)
CA (1) CA3136430A1 (https=)
WO (1) WO2020208169A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102930465B1 (ko) 2017-11-02 2026-02-25 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 ACE-tRNA를 이용한 유전 재할당을 통한 정지 코돈의 구조 방법
MX2022012955A (es) 2020-04-14 2023-02-23 Flagship Pioneering Innovations Vi Llc Composiciones de trem y usos de las mismas.
EP4202045A1 (en) 2021-12-22 2023-06-28 Universität Hamburg Synthetic transfer rna with modified nucleotides
EP4442826A1 (en) 2023-04-06 2024-10-09 Universität Hamburg Synthetic dna construct encoding transfer rna
EP4458967A1 (en) 2023-05-02 2024-11-06 Universität Hamburg Pharmaceutical composition comprising multiple suppressor transfer rnas

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036519A1 (en) * 1998-01-14 1999-07-22 Human Gene Therapy Research Institute HUMAN SUPPRESSOR tRNA OLIGONUCLEOTIDES AND METHODS OF USE FOR SAME
WO2018161032A1 (en) * 2017-03-03 2018-09-07 The Regents Of The University Of California RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033521A1 (en) 2001-10-16 2003-04-24 Massachusetts Institute Of Technology Inppressor trna system in mammalian cells for the introduction of unnatural amino acids in polypeptides.
EP1649004A4 (en) 2003-07-07 2008-04-09 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
US20060160175A1 (en) 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036519A1 (en) * 1998-01-14 1999-07-22 Human Gene Therapy Research Institute HUMAN SUPPRESSOR tRNA OLIGONUCLEOTIDES AND METHODS OF USE FOR SAME
WO2018161032A1 (en) * 2017-03-03 2018-09-07 The Regents Of The University Of California RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 77, no. 6, JPN6024011467, 2004, pages 1041 - 1049, ISSN: 0005295714 *
CHEMISTRY & BIOLOGY, vol. 9, no. 2, JPN6024011469, 2006, pages 237 - 244, ISSN: 0005519348 *
FEBS LETTERS, vol. 579, no. 30, JPN6024011471, 2005, pages 6769 - 6774, ISSN: 0005519346 *
JOURNAL OF MOLECULAR BIOLOGY, vol. 307, no. 3, JPN6024011468, 2001, pages 755 - 769, ISSN: 0005519349 *
JOURNAL OF MOLECULAR BIOLOGY, vol. 360, no. 3, JPN6024011470, 2006, pages 599 - 609, ISSN: 0005519347 *
NATURE CHEMISTRY (EUROPE PMC FUNDERS GROUP, AUTHOR MANUSCRIPTS, PMC4430801; AVAILABLE IN PMC 2015 MA, vol. 6, no. 5, JPN6024011472, 2014, pages 393 - 403, ISSN: 0005519345 *

Also Published As

Publication number Publication date
EP3953469A1 (en) 2022-02-16
JP2025131687A (ja) 2025-09-09
WO2020208169A1 (en) 2020-10-15
AU2020273255B2 (en) 2026-02-12
US20220162612A1 (en) 2022-05-26
AU2020273255A1 (en) 2021-10-28
CA3136430A1 (en) 2020-10-15

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