JP2022528696A - アンチコドンループを延長した合成転移ｒｎａ - Google Patents

アンチコドンループを延長した合成転移ｒｎａ Download PDF

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JP2022528696A
JP2022528696A JP2021559312A JP2021559312A JP2022528696A JP 2022528696 A JP2022528696 A JP 2022528696A JP 2021559312 A JP2021559312 A JP 2021559312A JP 2021559312 A JP2021559312 A JP 2021559312A JP 2022528696 A JP2022528696 A JP 2022528696A
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seq
trna
anticodon
nucleotide
transfer rna
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Japanese (ja)
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JP2022528696A5 (enExample
Inventor
イグナトヴァ、ゾヤ
トルダ、アンドリュー
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アークタラス テラピュウティクス、インク
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Priority claimed from LU101182A external-priority patent/LU101182B1/en
Application filed by アークタラス テラピュウティクス、インク filed Critical アークタラス テラピュウティクス、インク
Publication of JP2022528696A publication Critical patent/JP2022528696A/ja
Publication of JP2022528696A5 publication Critical patent/JP2022528696A5/ja
Priority to JP2025092679A priority Critical patent/JP2025131687A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021559312A 2019-04-11 2020-04-09 アンチコドンループを延長した合成転移ｒｎａ Pending JP2022528696A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025092679A JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
LU101182A LU101182B1 (en) 2019-04-11 2019-04-11 Synthetic transfer RNA with extended anticodon loop
LULU101182 2019-04-11
DE102019109664 2019-04-11
DE102019109664.2 2019-04-11
PCT/EP2020/060217 WO2020208169A1 (en) 2019-04-11 2020-04-09 Synthetic transfer rna with extended anticodon loop

Related Child Applications (1)

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JP2025092679A Division JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

Publications (2)

Publication Number Publication Date
JP2022528696A true JP2022528696A (ja) 2022-06-15
JP2022528696A5 JP2022528696A5 (enExample) 2023-04-06

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Family Applications (2)

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JP2021559312A Pending JP2022528696A (ja) 2019-04-11 2020-04-09 アンチコドンループを延長した合成転移ｒｎａ
JP2025092679A Pending JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

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JP2025092679A Pending JP2025131687A (ja) 2019-04-11 2025-06-03 アンチコドンループを延長した合成転移ｒｎａ

Country Status (6)

Country Link
US (1) US20220162612A1 (enExample)
EP (1) EP3953469A1 (enExample)
JP (2) JP2022528696A (enExample)
AU (1) AU2020273255B2 (enExample)
CA (1) CA3136430A1 (enExample)
WO (1) WO2020208169A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020004587A (es) 2017-11-02 2021-04-12 Univ Iowa Res Found Métodos de rescate de codones de paro mediante reasignación genética con ace-arnt.
JP7712270B2 (ja) 2019-11-01 2025-07-23 テバード バイオサイエンシズ インコーポレイテッド 未成熟終止コドン媒介障害を処置するための方法および組成物
BR112022020780A2 (pt) 2020-04-14 2022-11-29 Flagship Pioneering Innovations Vi Llc Composições de trem e usos das mesmas
EP4202045A1 (en) 2021-12-22 2023-06-28 Universität Hamburg Synthetic transfer rna with modified nucleotides
EP4442826A1 (en) 2023-04-06 2024-10-09 Universität Hamburg Synthetic dna construct encoding transfer rna
EP4458967A1 (en) 2023-05-02 2024-11-06 Universität Hamburg Pharmaceutical composition comprising multiple suppressor transfer rnas

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036519A1 (en) * 1998-01-14 1999-07-22 Human Gene Therapy Research Institute HUMAN SUPPRESSOR tRNA OLIGONUCLEOTIDES AND METHODS OF USE FOR SAME
WO2018161032A1 (en) * 2017-03-03 2018-09-07 The Regents Of The University Of California RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033521A1 (en) 2001-10-16 2003-04-24 Massachusetts Institute Of Technology Inppressor trna system in mammalian cells for the introduction of unnatural amino acids in polypeptides.
WO2005019415A2 (en) 2003-07-07 2005-03-03 The Scripps Research Institute Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
EP1704242A4 (en) 2003-07-07 2008-06-18 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036519A1 (en) * 1998-01-14 1999-07-22 Human Gene Therapy Research Institute HUMAN SUPPRESSOR tRNA OLIGONUCLEOTIDES AND METHODS OF USE FOR SAME
WO2018161032A1 (en) * 2017-03-03 2018-09-07 The Regents Of The University Of California RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 77, no. 6, JPN6024011467, 2004, pages 1041 - 1049, ISSN: 0005295714 *
CHEMISTRY & BIOLOGY, vol. 9, no. 2, JPN6024011469, 2006, pages 237 - 244, ISSN: 0005709156 *
FEBS LETTERS, vol. 579, no. 30, JPN6024011471, 2005, pages 6769 - 6774, ISSN: 0005709154 *
JOURNAL OF MOLECULAR BIOLOGY, vol. 307, no. 3, JPN6024011468, 2001, pages 755 - 769, ISSN: 0005709157 *
JOURNAL OF MOLECULAR BIOLOGY, vol. 360, no. 3, JPN6024011470, 2006, pages 599 - 609, ISSN: 0005709155 *
NATURE CHEMISTRY (EUROPE PMC FUNDERS GROUP, AUTHOR MANUSCRIPTS, PMC4430801; AVAILABLE IN PMC 2015 MA, vol. 6, no. 5, JPN6024011472, 2014, pages 393 - 403, ISSN: 0005709153 *

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Publication number Publication date
WO2020208169A1 (en) 2020-10-15
US20220162612A1 (en) 2022-05-26
AU2020273255A1 (en) 2021-10-28
JP2025131687A (ja) 2025-09-09
EP3953469A1 (en) 2022-02-16
CA3136430A1 (en) 2020-10-15
AU2020273255B2 (en) 2026-02-12

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