JP2022527641A - Ｃｘｃｒ４モジュレーターとしてのイミダゾリン誘導体 - Google Patents

Ｃｘｃｒ４モジュレーターとしてのイミダゾリン誘導体 Download PDF

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JP2022527641A
JP2022527641A JP2021560358A JP2021560358A JP2022527641A JP 2022527641 A JP2022527641 A JP 2022527641A JP 2021560358 A JP2021560358 A JP 2021560358A JP 2021560358 A JP2021560358 A JP 2021560358A JP 2022527641 A JP2022527641 A JP 2022527641A
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Japan
Prior art keywords
alkyl
methyl
thio
imidazol
thiazole
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JP2021560358A
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Japanese (ja)
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JP2022527641A5 (https=
Inventor
ベカドゥール・ベナティア，ナッシマ
ロデロ，マシュー
エルブバル，ジャン－フィリップ
ピエトランコスタ，ニコラス
スミス，ニカイア
バレ，アナイス
カスー，ジュリー
マイヤー，スタニスラス
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Centre National de la Recherche Scientifique CNRS
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Centre National de la Recherche Scientifique CNRS
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Publication of JP2022527641A publication Critical patent/JP2022527641A/ja
Publication of JP2022527641A5 publication Critical patent/JP2022527641A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021560358A 2019-03-29 2020-03-27 Ｃｘｃｒ４モジュレーターとしてのイミダゾリン誘導体 Pending JP2022527641A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19305409.5 2019-03-29
EP19305409 2019-03-29
PCT/EP2020/058728 WO2020201096A1 (en) 2019-03-29 2020-03-27 Imidazoline derivatives as cxcr4 modulators

Publications (2)

Publication Number Publication Date
JP2022527641A true JP2022527641A (ja) 2022-06-02
JP2022527641A5 JP2022527641A5 (https=) 2023-04-04

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ID=66102603

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JP2021560358A Pending JP2022527641A (ja) 2019-03-29 2020-03-27 Ｃｘｃｒ４モジュレーターとしてのイミダゾリン誘導体

Country Status (12)

Country Link
US (1) US20220144853A1 (https=)
EP (1) EP3947394A1 (https=)
JP (1) JP2022527641A (https=)
KR (1) KR20210146318A (https=)
CN (1) CN113939521A (https=)
AU (1) AU2020255206A1 (https=)
BR (1) BR112021019344A8 (https=)
CA (1) CA3132527A1 (https=)
IL (1) IL286399A (https=)
MX (1) MX2021011599A (https=)
SG (1) SG11202109671WA (https=)
WO (1) WO2020201096A1 (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006528178A (ja) * 2003-07-21 2006-12-14 アベンティス・ファーマスーティカルズ・インコーポレイテツド Ｐ２ｘ７イオンチャネルブロッカーとしての４，５−ジヒドロ−イミダゾール

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE565868A (https=) 1957-03-21
DE2348525A1 (de) 1972-09-28 1974-04-11 Searle & Co 2- eckige klammer auf 2-(2-methyl-5nitro-1-imidazolyl)-aethyl eckige klammer zu -2-thio-pseudoharnstoffe
US4205071A (en) 1976-05-14 1980-05-27 Smith Kline & French Laboratories Limited Pharmaceutical compositions having immunosuppressant activity and methods therefor
US4349674A (en) 1978-12-18 1982-09-14 American Home Products Corporation Quinoalinyl esters of carbamimidothioic acids
AR008789A1 (es) * 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US20040254221A1 (en) 2001-09-28 2004-12-16 Toru Yamazaki Novel Nitrogenous Compound and use thereof
CA3027296A1 (en) * 2016-06-16 2017-12-21 Centre National De La Recherche Scientifique Compounds useful for decreasing interferon level

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006528178A (ja) * 2003-07-21 2006-12-14 アベンティス・ファーマスーティカルズ・インコーポレイテツド Ｐ２ｘ７イオンチャネルブロッカーとしての４，５−ジヒドロ−イミダゾール

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
REGISTRY（STN）［ONLINE］, 29-MAR-2019[検索日：2024年1月22日], CAS 登録番号:RN 2296060-53-0他, JPN6024007654, ISSN: 0005444326 *
SONG, BAO AN ET AL.: "Indium-mediated facile synthesis of (6-chloro-3-pyridinyl)methyl heterocyclic thioether derivatives", CHINESE CHEMICAL LETTERS, vol. (2004), 15(10), 1140-1142, JPN6024007653, 2004, ISSN: 0005444325 *

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Publication number Publication date
WO2020201096A1 (en) 2020-10-08
CN113939521A (zh) 2022-01-14
CA3132527A1 (en) 2020-10-08
MX2021011599A (es) 2021-12-10
BR112021019344A8 (pt) 2022-12-06
IL286399A (en) 2021-10-31
AU2020255206A1 (en) 2021-10-14
KR20210146318A (ko) 2021-12-03
BR112021019344A2 (https=) 2021-12-14
EP3947394A1 (en) 2022-02-09
US20220144853A1 (en) 2022-05-12
SG11202109671WA (en) 2021-10-28

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