AU2020255206A1 - Imidazoline derivatives as CXCR4 modulators - Google Patents

Imidazoline derivatives as CXCR4 modulators Download PDF

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Publication number
AU2020255206A1
AU2020255206A1 AU2020255206A AU2020255206A AU2020255206A1 AU 2020255206 A1 AU2020255206 A1 AU 2020255206A1 AU 2020255206 A AU2020255206 A AU 2020255206A AU 2020255206 A AU2020255206 A AU 2020255206A AU 2020255206 A1 AU2020255206 A1 AU 2020255206A1
Authority
AU
Australia
Prior art keywords
alkyl
thio
methyl
imidazol
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2020255206A
Other languages
English (en)
Inventor
Anaïs BARRÉ
Nassima BEKADDOUR BENATIA
Julie CASSOU
Jean-Philippe Herbeuval
Stanislas Mayer
Nicolas PIETRANCOSTA
Mathieu RODERO
Nikaïa SMITH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Paris Cite
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Paris Cite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Paris Cite filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU2020255206A1 publication Critical patent/AU2020255206A1/en
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS CITÉ reassignment CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Amend patent request/document other than specification (104) Assignors: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Université de Paris
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2020255206A 2019-03-29 2020-03-27 Imidazoline derivatives as CXCR4 modulators Abandoned AU2020255206A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19305409.5 2019-03-29
EP19305409 2019-03-29
PCT/EP2020/058728 WO2020201096A1 (en) 2019-03-29 2020-03-27 Imidazoline derivatives as cxcr4 modulators

Publications (1)

Publication Number Publication Date
AU2020255206A1 true AU2020255206A1 (en) 2021-10-14

Family

ID=66102603

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020255206A Abandoned AU2020255206A1 (en) 2019-03-29 2020-03-27 Imidazoline derivatives as CXCR4 modulators

Country Status (12)

Country Link
US (1) US20220144853A1 (https=)
EP (1) EP3947394A1 (https=)
JP (1) JP2022527641A (https=)
KR (1) KR20210146318A (https=)
CN (1) CN113939521A (https=)
AU (1) AU2020255206A1 (https=)
BR (1) BR112021019344A8 (https=)
CA (1) CA3132527A1 (https=)
IL (1) IL286399A (https=)
MX (1) MX2021011599A (https=)
SG (1) SG11202109671WA (https=)
WO (1) WO2020201096A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE565868A (https=) 1957-03-21
DE2348525A1 (de) 1972-09-28 1974-04-11 Searle & Co 2- eckige klammer auf 2-(2-methyl-5nitro-1-imidazolyl)-aethyl eckige klammer zu -2-thio-pseudoharnstoffe
US4205071A (en) 1976-05-14 1980-05-27 Smith Kline & French Laboratories Limited Pharmaceutical compositions having immunosuppressant activity and methods therefor
US4349674A (en) 1978-12-18 1982-09-14 American Home Products Corporation Quinoalinyl esters of carbamimidothioic acids
AR008789A1 (es) * 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US20040254221A1 (en) 2001-09-28 2004-12-16 Toru Yamazaki Novel Nitrogenous Compound and use thereof
GB0324498D0 (en) * 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
CA3027296A1 (en) * 2016-06-16 2017-12-21 Centre National De La Recherche Scientifique Compounds useful for decreasing interferon level

Also Published As

Publication number Publication date
WO2020201096A1 (en) 2020-10-08
CN113939521A (zh) 2022-01-14
CA3132527A1 (en) 2020-10-08
MX2021011599A (es) 2021-12-10
BR112021019344A8 (pt) 2022-12-06
IL286399A (en) 2021-10-31
KR20210146318A (ko) 2021-12-03
BR112021019344A2 (https=) 2021-12-14
EP3947394A1 (en) 2022-02-09
JP2022527641A (ja) 2022-06-02
US20220144853A1 (en) 2022-05-12
SG11202109671WA (en) 2021-10-28

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Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Free format text: FORMER NAME(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE PARIS

Owner name: UNIVERSITE PARIS CITE

Free format text: FORMER NAME(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE PARIS

MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application