JP2022527108A - Ｋｒａｓ関連疾患または障害の治療のための組成物及び方法 - Google Patents

Ｋｒａｓ関連疾患または障害の治療のための組成物及び方法 Download PDF

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JP2022527108A
JP2022527108A JP2021558626A JP2021558626A JP2022527108A JP 2022527108 A JP2022527108 A JP 2022527108A JP 2021558626 A JP2021558626 A JP 2021558626A JP 2021558626 A JP2021558626 A JP 2021558626A JP 2022527108 A JP2022527108 A JP 2022527108A
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kras
nucleotides
seq
sequence
nucleic acid
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シャンティ ガネーシュ
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Dicerna Pharmaceuticals Inc
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2021558626A 2019-03-29 2020-03-27 Ｋｒａｓ関連疾患または障害の治療のための組成物及び方法 Pending JP2022527108A (ja)

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US201962826121P 2019-03-29 2019-03-29
US62/826,121 2019-03-29
PCT/US2020/025125 WO2020205473A1 (en) 2019-03-29 2020-03-27 Compositions and methods for the treatment of kras associated diseases or disorders

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JP2022527108A true JP2022527108A (ja) 2022-05-30
JPWO2020205473A5 JPWO2020205473A5 (https=) 2023-04-04
JP2022527108A5 JP2022527108A5 (https=) 2023-04-04

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US (1) US20220154189A1 (https=)
EP (1) EP3947681A1 (https=)
JP (1) JP2022527108A (https=)
KR (1) KR20210145213A (https=)
CN (1) CN113924365A (https=)
AU (1) AU2020253823A1 (https=)
BR (1) BR112021018739A2 (https=)
CA (1) CA3134486A1 (https=)
CL (1) CL2021002533A1 (https=)
IL (1) IL286636A (https=)
MX (1) MX2021011928A (https=)
SG (1) SG11202110174PA (https=)
WO (1) WO2020205473A1 (https=)

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US11932633B2 (en) 2018-05-07 2024-03-19 Mirati Therapeutics, Inc. KRas G12C inhibitors
WO2020055761A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
CA3112043A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
SMT202500028T1 (it) 2018-09-10 2025-03-12 Mirati Therapeutics Inc Terapie combinate
JP2022500385A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
CN113164418A (zh) 2018-12-05 2021-07-23 米拉蒂治疗股份有限公司 组合疗法
WO2020146613A1 (en) 2019-01-10 2020-07-16 Mirati Therapeutics, Inc. Kras g12c inhibitors
WO2021041671A1 (en) 2019-08-29 2021-03-04 Mirati Therapeutics, Inc. Kras g12d inhibitors
CN114761012B (zh) 2019-09-24 2025-03-21 米拉蒂治疗股份有限公司 组合疗法
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
WO2022056307A1 (en) 2020-09-11 2022-03-17 Mirati Therapeutics, Inc. Crystalline forms of a kras g12c inhibitor
EP4225383A4 (en) * 2020-10-08 2024-12-11 Kumquat Biosciences Inc. MODULATORS OF CELLULAR PROLIFERATION AND THEIR USES
WO2022132200A1 (en) 2020-12-15 2022-06-23 Mirati Therapeutics, Inc. Azaquinazoline pan-kras inhibitors
EP4262803A4 (en) 2020-12-16 2025-03-12 Mirati Therapeutics, Inc. Tetrahydropyridopyrimidine pan-kras inhibitors
CA3214540A1 (en) * 2021-04-22 2022-10-27 Pasi A. Janne Compositions and methods for treating cancer
MX2024008358A (es) * 2022-01-21 2024-07-19 Chugai Pharmaceutical Co Ltd Medicina para tratar o prevenir el cancer.
CN121015887A (zh) * 2025-10-22 2025-11-28 天津市肿瘤医院（天津医科大学肿瘤医院） 预测胰腺癌对kras抑制剂耐药性的生物标志物及其应用

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WO2017173304A1 (en) * 2016-04-01 2017-10-05 Avidity Biosciences Llc Kras nucleic acids and uses thereof
WO2018098352A2 (en) * 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression

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