JP2022526855A5 - - Google Patents
Info
- Publication number
- JP2022526855A5 JP2022526855A5 JP2021560632A JP2021560632A JP2022526855A5 JP 2022526855 A5 JP2022526855 A5 JP 2022526855A5 JP 2021560632 A JP2021560632 A JP 2021560632A JP 2021560632 A JP2021560632 A JP 2021560632A JP 2022526855 A5 JP2022526855 A5 JP 2022526855A5
- Authority
- JP
- Japan
- Prior art keywords
- bone marrow
- composition according
- msc secretome
- derived msc
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025083941A JP2025134698A (ja) | 2019-04-09 | 2025-05-20 | 間葉系幹細胞由来のセクレトームを作製および使用するためのプロセス |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962831371P | 2019-04-09 | 2019-04-09 | |
| US62/831,371 | 2019-04-09 | ||
| US201962929035P | 2019-10-31 | 2019-10-31 | |
| US62/929,035 | 2019-10-31 | ||
| US16/785,463 | 2020-02-07 | ||
| US16/785,470 | 2020-02-07 | ||
| US16/785,470 US10758571B1 (en) | 2019-04-09 | 2020-02-07 | Processes for making and using a mesenchymal stem cell derived secretome |
| US16/785,463 US10881693B2 (en) | 2019-04-09 | 2020-02-07 | Processes for making and using a mesenchymal stem cell derived secretome |
| PCT/US2020/027093 WO2020210248A1 (en) | 2019-04-09 | 2020-04-07 | Processes for making and using a mesenchymal stem cell derived secretome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025083941A Division JP2025134698A (ja) | 2019-04-09 | 2025-05-20 | 間葉系幹細胞由来のセクレトームを作製および使用するためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022526855A JP2022526855A (ja) | 2022-05-26 |
| JP2022526855A5 true JP2022526855A5 (https=) | 2023-07-12 |
| JP7763664B2 JP7763664B2 (ja) | 2025-11-04 |
Family
ID=72241604
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560632A Active JP7763664B2 (ja) | 2019-04-09 | 2020-04-07 | 間葉系幹細胞由来のセクレトームを作製および使用するためのプロセス |
| JP2025083941A Pending JP2025134698A (ja) | 2019-04-09 | 2025-05-20 | 間葉系幹細胞由来のセクレトームを作製および使用するためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025083941A Pending JP2025134698A (ja) | 2019-04-09 | 2025-05-20 | 間葉系幹細胞由来のセクレトームを作製および使用するためのプロセス |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US10881693B2 (https=) |
| EP (1) | EP3952892A4 (https=) |
| JP (2) | JP7763664B2 (https=) |
| KR (2) | KR20220047210A (https=) |
| CN (1) | CN114269359A (https=) |
| AU (1) | AU2020270892A1 (https=) |
| BR (1) | BR112021020450A2 (https=) |
| CA (1) | CA3136614A1 (https=) |
| CL (1) | CL2021002655A1 (https=) |
| MX (1) | MX2021012461A (https=) |
| WO (1) | WO2020210248A1 (https=) |
Families Citing this family (23)
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|---|---|---|---|---|
| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| US12569517B2 (en) | 2019-02-07 | 2026-03-10 | Direct Biologics, Llc | Method for treating osteoarthritis with mesenchymal stem cell exosomes |
| US10881693B2 (en) | 2019-04-09 | 2021-01-05 | Combangio, Inc. | Processes for making and using a mesenchymal stem cell derived secretome |
| US12213995B2 (en) | 2019-07-18 | 2025-02-04 | Direct Biologics, Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| IT201900022029A1 (it) * | 2019-11-25 | 2021-05-25 | Dompe Farm Spa | Formulazioni oftalmiche |
| WO2021123320A1 (en) * | 2019-12-20 | 2021-06-24 | Dr. Kalali Prof. Mostafazadeh Dipl. Ing. Miedl (Kmm) Gesellschaft Bürgerlichen Rechts | A composition and its use for a universal therapy against tumor cells |
| WO2021207282A2 (en) | 2020-04-07 | 2021-10-14 | Combangio, Inc. | Lyophilized mesenchymal stem cell derived secretome and uses thereof |
| KR20230004709A (ko) | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| EP3970732A1 (en) * | 2020-09-17 | 2022-03-23 | Hunan Yuanpin Cell Technology Co. Ltd | Use of mesenchymal stem cells in the treatment of viral infections and/or complications caused by viral infections |
| CN112656816A (zh) * | 2021-01-15 | 2021-04-16 | 浙江大学 | 一种负载外泌体的纤维蛋白胶及其应用 |
| US20220378846A1 (en) * | 2021-06-01 | 2022-12-01 | U-Neuron Biomedical Inc. | Use of secretome of amniotic fluid stem cell in the treatment of dry eye disease |
| TWI864306B (zh) * | 2021-07-07 | 2024-12-01 | 三鼎生物科技股份有限公司 | 間質幹細胞培養物及其製備方法 |
| CN113583950A (zh) * | 2021-08-06 | 2021-11-02 | 合肥滴碧云生物科技有限公司 | 一种制备干细胞活性因子的方法及其应用 |
| CN114350603B (zh) * | 2022-01-23 | 2022-08-23 | 上海揽微赛尔生物科技有限公司 | 包含外泌体的间充质干细胞胞外基质及其制备和在细胞修复中的应用 |
| CN115282286B (zh) * | 2022-02-09 | 2023-05-02 | 天津医科大学眼科医院 | 一种治疗眼部新生血管类疾病的纳米复合体及应用 |
| KR20250044282A (ko) * | 2022-07-08 | 2025-03-31 | 컴반지오, 인크. | 분비체 활성 분석을 위한 방법 및 검정 |
| CN116473919A (zh) * | 2023-03-13 | 2023-07-25 | 陕西初源外泌体生物科技有限公司 | 一种用于治疗视神经损伤的外泌体滴眼液及其制备方法 |
| WO2024192119A1 (en) * | 2023-03-14 | 2024-09-19 | Direct Biologics, Llc | Wound healing compositions and methods thereof |
| WO2025054528A2 (en) * | 2023-09-06 | 2025-03-13 | Theratom Bio, Inc. | Modified stem cell secretome topical eye compositions and uses thereof |
| FR3153241A1 (fr) * | 2023-09-22 | 2025-03-28 | Med'inn'pharma | Préparation pharmaceutique pro-résolutive sous forme de gel |
| US20250222035A1 (en) * | 2024-01-10 | 2025-07-10 | Combangio, Inc. | Processes for making and using a mesenchyme stem cell secretome for limbal stem cell deficiency (lscd) treatment |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| CN121102278A (zh) * | 2025-11-17 | 2025-12-12 | 中国农业科学院特产研究所 | 含鹿茸干细胞分泌因子的滴眼液及其应用 |
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| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US20060165667A1 (en) | 2004-12-03 | 2006-07-27 | Case Western Reserve University | Novel methods, compositions and devices for inducing neovascularization |
| US20060222634A1 (en) | 2005-03-31 | 2006-10-05 | Clarke Diana L | Amnion-derived cell compositions, methods of making and uses thereof |
| WO2008020815A1 (en) | 2006-08-15 | 2008-02-21 | Agency For Science, Technology And Research | Mesenchymal stem cell conditioned medium |
| US8871198B2 (en) | 2006-03-29 | 2014-10-28 | Stemnion, Inc. | Methods related to wound healing |
| WO2008024996A2 (en) | 2006-08-24 | 2008-02-28 | Johnstone Brian H | Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith |
| WO2009045359A1 (en) | 2007-10-01 | 2009-04-09 | Stemnion, Inc. | Skin replacement compositions and methods |
| US20090054339A1 (en) | 2007-08-22 | 2009-02-26 | Marshall Vivienne S | Novel cellular factor-containing solution compositions |
| EP2254586B1 (en) | 2008-02-22 | 2015-04-08 | Agency For Science, Technology And Research (A*star) | Mesenchymal stem cell particles |
| US20110158958A1 (en) | 2009-12-07 | 2011-06-30 | Sing George L | Methods for treating ophthalmic disorders, diseases and injuries |
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| EP2251028A1 (en) * | 2009-05-12 | 2010-11-17 | Biocompatibles Uk Ltd. | Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor |
| DK2451964T3 (en) | 2009-07-10 | 2018-04-30 | Histogen Inc | Conditioned medium and extracellular matrix compositions from cells grown under hypoxic conditions |
| US20110206647A1 (en) * | 2010-02-25 | 2011-08-25 | Abt Holding Company | Modulation of Angiogenesis |
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| ITTO20111183A1 (it) | 2011-12-21 | 2013-06-22 | Univ Degli Studi Torino | Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia |
| HK1202581A1 (en) | 2012-02-13 | 2015-10-02 | Gamida-Cell Ltd. | Mesenchymal stem cells conditioned medium and methods of generating and using the same |
| ITTO20120859A1 (it) * | 2012-10-02 | 2014-04-03 | Univ Degli Studi Torino | Nuova applicazione terapeutica di un mezzo condizionato da cellule staminali mesenchimali placentari |
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| EP2943069B1 (en) | 2013-01-09 | 2018-08-15 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
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| US9636364B2 (en) | 2013-12-04 | 2017-05-02 | Stemnion, Inc. | Methods for treating ocular contusion and blunt injury and traumatic injury to the optic nerve |
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| SG11201704668PA (en) | 2014-12-16 | 2017-07-28 | Janssen Biotech Inc | Treatment of retinal degeneration using progenitor cells |
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| KR101566450B1 (ko) | 2015-04-03 | 2015-11-05 | (유)스템메디케어 | 중간엽 줄기세포에서 단백질의 대량 생산 방법 |
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| RU2708329C2 (ru) | 2016-05-31 | 2019-12-05 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток, композиции и способы применения |
| WO2017217967A1 (en) | 2016-06-13 | 2017-12-21 | Noveome Biotherapeutics, Inc. | Novel methods for delivering therapeutic agents to the eye via nasal passages |
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| US20190231694A1 (en) | 2016-10-12 | 2019-08-01 | Agency For Science, Technology And Research | Method for lyophilising an exosome |
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| JP2020505345A (ja) | 2017-01-16 | 2020-02-20 | セルズ フォー セルズ エセ．アー． | 乏血小板血漿（ｐｐｐ）に封入された実質的に純粋な多能性間質細胞集団を含む組成物 |
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| EP3624731A4 (en) | 2017-05-18 | 2021-02-24 | The Board of Trustees of the Leland Stanford Junior University | TARGETED IN-SITU THERAPEUTIC ADMINISTRATION OF SECRETED FACTORS FROM STEM CELLS FOR THE TREATMENT OF DAMAGED TISSUE |
| EP3655525A4 (en) | 2017-07-16 | 2021-04-21 | Ramot at Tel-Aviv University Ltd. | STEM CELL SECRETOME FROM HUMAN MUCCOUS |
| US10364270B2 (en) | 2017-10-02 | 2019-07-30 | Pro Sunfun Biotech Research And Developmment Co., Ltd. | Eye-care peptide, its composition and method of using the same |
| CN108517002A (zh) * | 2018-04-20 | 2018-09-11 | 命之本源医疗科技（北京）有限公司 | 一种干细胞培养上清分泌蛋白的稳定剂 |
| US10881693B2 (en) | 2019-04-09 | 2021-01-05 | Combangio, Inc. | Processes for making and using a mesenchymal stem cell derived secretome |
-
2020
- 2020-02-07 US US16/785,463 patent/US10881693B2/en active Active
- 2020-02-07 US US16/785,470 patent/US10758571B1/en active Active
- 2020-04-07 EP EP20788534.4A patent/EP3952892A4/en active Pending
- 2020-04-07 KR KR1020217036569A patent/KR20220047210A/ko not_active Ceased
- 2020-04-07 WO PCT/US2020/027093 patent/WO2020210248A1/en not_active Ceased
- 2020-04-07 CN CN202080041151.5A patent/CN114269359A/zh active Pending
- 2020-04-07 CA CA3136614A patent/CA3136614A1/en active Pending
- 2020-04-07 JP JP2021560632A patent/JP7763664B2/ja active Active
- 2020-04-07 BR BR112021020450A patent/BR112021020450A2/pt unknown
- 2020-04-07 KR KR1020257028698A patent/KR20250135331A/ko active Pending
- 2020-04-07 AU AU2020270892A patent/AU2020270892A1/en active Pending
- 2020-04-07 US US16/842,696 patent/US11654160B2/en active Active
- 2020-04-07 MX MX2021012461A patent/MX2021012461A/es unknown
-
2021
- 2021-02-25 US US17/185,801 patent/US11129853B2/en active Active
- 2021-10-12 CL CL2021002655A patent/CL2021002655A1/es unknown
-
2023
- 2023-04-17 US US18/301,947 patent/US20240033297A1/en active Pending
-
2025
- 2025-05-20 JP JP2025083941A patent/JP2025134698A/ja active Pending
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