JP2022524380A - 音響細胞外マトリックスヒドロゲルおよびそれらの使用 - Google Patents
音響細胞外マトリックスヒドロゲルおよびそれらの使用 Download PDFInfo
- Publication number
- JP2022524380A JP2022524380A JP2021553299A JP2021553299A JP2022524380A JP 2022524380 A JP2022524380 A JP 2022524380A JP 2021553299 A JP2021553299 A JP 2021553299A JP 2021553299 A JP2021553299 A JP 2021553299A JP 2022524380 A JP2022524380 A JP 2022524380A
- Authority
- JP
- Japan
- Prior art keywords
- ecm
- acoustic
- hydrogel
- temperature
- hydrogels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025259431A JP2026062723A (ja) | 2019-03-13 | 2025-12-17 | 音響細胞外マトリックスヒドロゲルおよびそれらの使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962817787P | 2019-03-13 | 2019-03-13 | |
| US62/817,787 | 2019-03-13 | ||
| US201962950565P | 2019-12-19 | 2019-12-19 | |
| US62/950,565 | 2019-12-19 | ||
| PCT/US2020/022433 WO2020186082A1 (en) | 2019-03-13 | 2020-03-12 | Acoustic extracellular matrix hydrogels and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025259431A Division JP2026062723A (ja) | 2019-03-13 | 2025-12-17 | 音響細胞外マトリックスヒドロゲルおよびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022524380A true JP2022524380A (ja) | 2022-05-02 |
| JP2022524380A5 JP2022524380A5 (https=) | 2023-03-20 |
Family
ID=70190204
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021553299A Pending JP2022524380A (ja) | 2019-03-13 | 2020-03-12 | 音響細胞外マトリックスヒドロゲルおよびそれらの使用 |
| JP2025259431A Pending JP2026062723A (ja) | 2019-03-13 | 2025-12-17 | 音響細胞外マトリックスヒドロゲルおよびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025259431A Pending JP2026062723A (ja) | 2019-03-13 | 2025-12-17 | 音響細胞外マトリックスヒドロゲルおよびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12263270B2 (https=) |
| EP (1) | EP3937994A1 (https=) |
| JP (2) | JP2022524380A (https=) |
| KR (2) | KR102930622B1 (https=) |
| CN (2) | CN116510085B (https=) |
| AU (2) | AU2020235627B2 (https=) |
| CA (1) | CA3130684A1 (https=) |
| WO (1) | WO2020186082A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017227790B2 (en) | 2016-03-02 | 2023-03-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Matrix bound nanovesicles and their use |
| KR102872720B1 (ko) | 2017-05-05 | 2025-10-16 | 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 기질 결합 소낭의 안구에의 적용 |
| US12491263B2 (en) | 2019-05-13 | 2025-12-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Polymer-based implant for retinal therapy and methods of making and using the same |
| US12383700B2 (en) | 2019-06-13 | 2025-08-12 | Hollister Incorporated | Reusable urinary catheter products |
| EP4628107A3 (en) | 2019-06-25 | 2025-12-17 | Hollister Incorporated | Reusable urinary catheter products |
| CN116157138A (zh) | 2020-09-11 | 2023-05-23 | 联邦高等教育系统匹兹堡大学 | 源自细胞外基质的最终灭菌的水凝胶或胶体悬浮液的制备方法及其用途 |
| US20250017769A1 (en) * | 2021-11-16 | 2025-01-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Polymer-based gel implant for retinal therapy and methods of making and using the same |
| AU2023249793A1 (en) * | 2022-04-08 | 2024-11-21 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Matrix bound nanovesicles encapsulated in hydrogels |
| CN114939129A (zh) * | 2022-06-16 | 2022-08-26 | 重庆医科大学 | 治疗三阴性乳腺癌的脱细胞基质复合水凝胶及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57159485A (en) * | 1981-03-27 | 1982-10-01 | Kureha Chem Ind Co Ltd | Base material for tissue cultivation |
| US20060070631A1 (en) * | 2004-09-27 | 2006-04-06 | Boston Scientific Scimed, Inc. | Devices and methods for agent-assisted medical procedures |
| JP2009528090A (ja) * | 2006-02-27 | 2009-08-06 | グローバス メディカル インコーポレイティッド | 石灰化ゼラチンに由来する骨移植材 |
| US20160166735A1 (en) * | 2013-03-15 | 2016-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Injectable composition for in-situ repair and regeneration of an injured ligament or tendon and methods of use |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
| US4956178A (en) | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
| US5281422A (en) | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
| US5352463A (en) | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
| US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US6485723B1 (en) | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
| US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
| WO1996031232A1 (en) | 1995-04-07 | 1996-10-10 | Purdue Research Foundation | Tissue graft and method for urinary bladder reconstruction |
| CA2160647C (en) | 1995-10-16 | 2002-05-28 | Thomas William Garay | Helical bearing anchor catcher |
| AU732726B2 (en) | 1996-12-10 | 2001-04-26 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
| US6696270B2 (en) | 1996-12-10 | 2004-02-24 | Purdue Research Foundation | Gastric submucosal tissue as a novel diagnostic tool |
| DE69720252T2 (de) | 1996-12-10 | 2003-12-04 | Purdue Research Foundation, West Lafayette | Gewebetransplantat aus der magensubmukosa |
| US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
| US20070190165A1 (en) | 2005-10-21 | 2007-08-16 | Brey Eric M | Tissue-specific basement membrane gels |
| US8361503B2 (en) | 2007-03-02 | 2013-01-29 | University of Pittsburgh—of the Commonwealth System of Higher Education | Extracellular matrix-derived gels and related methods |
| US8187616B2 (en) | 2007-05-29 | 2012-05-29 | Trustees Of Tufts College | Method for silk fibroin gelation using sonication |
| CA2654754A1 (en) * | 2009-02-19 | 2010-08-19 | Axcelon Biopolymers Corporation | Anisotropic nanocomposite hydrogel |
| US20120020932A1 (en) | 2010-07-02 | 2012-01-26 | Zimmer Orthobiologics, Inc. | Thermosensitive hydrogel composition and method |
| EP2726056A4 (en) * | 2011-06-28 | 2015-01-14 | Veris Medical Inc | SYSTEM AND METHOD FOR COLLAGEN INSULATION |
| US20150165091A1 (en) | 2012-03-30 | 2015-06-18 | University Of Rochester | Controlling extracellular matrix protein microstructure with ultrasound |
| US9861662B2 (en) | 2013-07-03 | 2018-01-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bone-derived extra cellular matrix gel |
| ITMI20131924A1 (it) | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| AU2015231110B2 (en) | 2014-03-21 | 2019-03-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix |
| WO2015164728A1 (en) | 2014-04-24 | 2015-10-29 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Fractionating extracellular matrix to modulate bioactivity and the host response |
| EP3319653A4 (en) | 2015-07-10 | 2019-03-27 | University of Pittsburgh - Of the Commonwealth System of Higher Education | METHOD FOR PRODUCING ECM EQUIPMENT AND HYDROGELS FROM COLON |
| EP3349814B1 (en) | 2015-09-18 | 2021-03-17 | University of Pittsburgh- Of the Commonwealth System of Higher Education | Non-gelling soluble extracellular matrix with biological activity |
| CA3011294A1 (en) | 2016-01-13 | 2017-07-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Vascular extracellular matrix hydrogel |
| JP2019513038A (ja) | 2016-03-14 | 2019-05-23 | リージェンティーズ コーポレイション | 炎症性腸疾患を処置するための方法および組成物 |
| CN106390188A (zh) * | 2016-04-01 | 2017-02-15 | 浙江理工大学 | 一种具有创面修复功效的水凝胶及其制备方法 |
| JP2019520822A (ja) | 2016-06-16 | 2019-07-25 | アスペクト バイオシステムズ リミティド | バイオ印刷された半月板移植片及びその使用方法 |
| EP3500193A4 (en) | 2016-08-19 | 2020-04-08 | Regentys Corporation | EXTRACELLULAR MATRIX FOR TISSUE RECONSTRUCTION OF MUCOUS TISSUE |
| CA3049990A1 (en) | 2017-03-02 | 2018-09-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer |
| EP3589292B1 (en) | 2017-03-02 | 2023-08-23 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Ecm hydrogel for treating esophageal inflammation |
| US11389569B2 (en) | 2017-04-03 | 2022-07-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler |
| CN108295311A (zh) | 2018-03-07 | 2018-07-20 | 南京市第医院 | 一种温敏型肾脏细胞外基质水凝胶的制备方法 |
| CN115671410B (zh) | 2018-06-21 | 2024-06-18 | 联邦高等教育系统匹兹堡大学 | 膀胱ecm水凝胶作为食管粘膜下层流体垫的用途 |
| CN115487364B (zh) | 2018-06-21 | 2024-02-23 | 联邦高等教育系统匹兹堡大学 | 细胞外基质(ecm)水凝胶作为粘膜下流体垫 |
| AU2019288586B2 (en) | 2018-06-21 | 2024-06-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of an extracellular matrix (ECM) hydrogel as an esophageal submucosal fluid cushion |
-
2020
- 2020-03-12 AU AU2020235627A patent/AU2020235627B2/en active Active
- 2020-03-12 KR KR1020217033030A patent/KR102930622B1/ko active Active
- 2020-03-12 US US17/434,925 patent/US12263270B2/en active Active
- 2020-03-12 KR KR1020267005000A patent/KR20260028187A/ko active Pending
- 2020-03-12 JP JP2021553299A patent/JP2022524380A/ja active Pending
- 2020-03-12 WO PCT/US2020/022433 patent/WO2020186082A1/en not_active Ceased
- 2020-03-12 CN CN202310410850.8A patent/CN116510085B/zh active Active
- 2020-03-12 EP EP20717482.2A patent/EP3937994A1/en active Pending
- 2020-03-12 CN CN202080020191.1A patent/CN113557040B/zh active Active
- 2020-03-12 CA CA3130684A patent/CA3130684A1/en active Pending
-
2025
- 2025-01-17 US US19/030,279 patent/US20250235580A1/en active Pending
- 2025-12-17 JP JP2025259431A patent/JP2026062723A/ja active Pending
-
2026
- 2026-04-02 AU AU2026202523A patent/AU2026202523A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57159485A (en) * | 1981-03-27 | 1982-10-01 | Kureha Chem Ind Co Ltd | Base material for tissue cultivation |
| US20060070631A1 (en) * | 2004-09-27 | 2006-04-06 | Boston Scientific Scimed, Inc. | Devices and methods for agent-assisted medical procedures |
| JP2009528090A (ja) * | 2006-02-27 | 2009-08-06 | グローバス メディカル インコーポレイティッド | 石灰化ゼラチンに由来する骨移植材 |
| US20160166735A1 (en) * | 2013-03-15 | 2016-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Injectable composition for in-situ repair and regeneration of an injured ligament or tendon and methods of use |
Non-Patent Citations (1)
| Title |
|---|
| REIZA D. VENTURA ET AL.,: "In-vitro and in-vivo evaluation of hemostatic potential of decellularized ECM hydrogels", MATERIALS LETTERS, vol. 232, JPN6024008674, 2018, pages 130 - 133, ISSN: 0005494216 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113557040B (zh) | 2023-05-05 |
| US20250235580A1 (en) | 2025-07-24 |
| WO2020186082A1 (en) | 2020-09-17 |
| AU2026202523A1 (en) | 2026-04-23 |
| CN116510085B (zh) | 2026-01-02 |
| US20220143265A1 (en) | 2022-05-12 |
| CN113557040A (zh) | 2021-10-26 |
| CN116510085A (zh) | 2023-08-01 |
| JP2026062723A (ja) | 2026-04-10 |
| KR102930622B1 (ko) | 2026-02-24 |
| KR20260028187A (ko) | 2026-03-03 |
| US12263270B2 (en) | 2025-04-01 |
| AU2020235627A1 (en) | 2021-08-19 |
| KR20210142003A (ko) | 2021-11-23 |
| CA3130684A1 (en) | 2020-09-17 |
| EP3937994A1 (en) | 2022-01-19 |
| AU2020235627B2 (en) | 2026-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250235580A1 (en) | Acoustic extracellular matrix hydrogels and their use | |
| JP7742172B2 (ja) | 粘膜下流体クッションとしての細胞外マトリックス(ecm)ヒドロゲル | |
| JP7823916B2 (ja) | 細胞外マトリックスに由来する最終滅菌ハイドロゲルまたはコロイド懸濁液の調製方法およびその使用 | |
| KR20210022717A (ko) | 식도의 점막하 유체 쿠션으로 방광 ecm 하이드로겔의 사용 | |
| CN115444993B (zh) | 细胞外基质(ecm)水凝胶作为食管粘膜下流体垫的用途 | |
| US20250228896A1 (en) | Matrix bound nanovesicles encapsulated in hydrogels | |
| JP2026074097A (ja) | 細胞外マトリックスに由来する最終滅菌ハイドロゲルまたはコロイド懸濁液の調製方法およびその使用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230310 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20230310 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20240209 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20240304 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20240513 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240902 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20241226 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20250314 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250605 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20250826 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20251217 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20251224 |