CA3130684A1 - Acoustic extracellular matrix hydrogels and their use - Google Patents

Acoustic extracellular matrix hydrogels and their use Download PDF

Info

Publication number
CA3130684A1
CA3130684A1 CA3130684A CA3130684A CA3130684A1 CA 3130684 A1 CA3130684 A1 CA 3130684A1 CA 3130684 A CA3130684 A CA 3130684A CA 3130684 A CA3130684 A CA 3130684A CA 3130684 A1 CA3130684 A1 CA 3130684A1
Authority
CA
Canada
Prior art keywords
ecm
hydrogel
acoustic
ultrasound
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3130684A
Other languages
English (en)
French (fr)
Inventor
Stephen Francis Badylak
George S. Hussey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of CA3130684A1 publication Critical patent/CA3130684A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3130684A 2019-03-13 2020-03-12 Acoustic extracellular matrix hydrogels and their use Pending CA3130684A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962817787P 2019-03-13 2019-03-13
US62/817,787 2019-03-13
US201962950565P 2019-12-19 2019-12-19
US62/950,565 2019-12-19
PCT/US2020/022433 WO2020186082A1 (en) 2019-03-13 2020-03-12 Acoustic extracellular matrix hydrogels and their use

Publications (1)

Publication Number Publication Date
CA3130684A1 true CA3130684A1 (en) 2020-09-17

Family

ID=70190204

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3130684A Pending CA3130684A1 (en) 2019-03-13 2020-03-12 Acoustic extracellular matrix hydrogels and their use

Country Status (8)

Country Link
US (2) US12263270B2 (https=)
EP (1) EP3937994A1 (https=)
JP (2) JP2022524380A (https=)
KR (2) KR102930622B1 (https=)
CN (2) CN116510085B (https=)
AU (2) AU2020235627B2 (https=)
CA (1) CA3130684A1 (https=)
WO (1) WO2020186082A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017227790B2 (en) 2016-03-02 2023-03-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound nanovesicles and their use
KR102872720B1 (ko) 2017-05-05 2025-10-16 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 기질 결합 소낭의 안구에의 적용
US12491263B2 (en) 2019-05-13 2025-12-09 University of Pittsburgh—of the Commonwealth System of Higher Education Polymer-based implant for retinal therapy and methods of making and using the same
US12383700B2 (en) 2019-06-13 2025-08-12 Hollister Incorporated Reusable urinary catheter products
EP4628107A3 (en) 2019-06-25 2025-12-17 Hollister Incorporated Reusable urinary catheter products
CN116157138A (zh) 2020-09-11 2023-05-23 联邦高等教育系统匹兹堡大学 源自细胞外基质的最终灭菌的水凝胶或胶体悬浮液的制备方法及其用途
US20250017769A1 (en) * 2021-11-16 2025-01-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polymer-based gel implant for retinal therapy and methods of making and using the same
AU2023249793A1 (en) * 2022-04-08 2024-11-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound nanovesicles encapsulated in hydrogels
CN114939129A (zh) * 2022-06-16 2022-08-26 重庆医科大学 治疗三阴性乳腺癌的脱细胞基质复合水凝胶及其制备方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5832876B2 (ja) 1981-03-27 1983-07-15 呉羽化学工業株式会社 組織培養基材
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
WO1996031232A1 (en) 1995-04-07 1996-10-10 Purdue Research Foundation Tissue graft and method for urinary bladder reconstruction
CA2160647C (en) 1995-10-16 2002-05-28 Thomas William Garay Helical bearing anchor catcher
AU732726B2 (en) 1996-12-10 2001-04-26 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
US6696270B2 (en) 1996-12-10 2004-02-24 Purdue Research Foundation Gastric submucosal tissue as a novel diagnostic tool
DE69720252T2 (de) 1996-12-10 2003-12-04 Purdue Research Foundation, West Lafayette Gewebetransplantat aus der magensubmukosa
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US7909809B2 (en) * 2004-09-27 2011-03-22 Boston Scientific Scimed, Inc. Devices and methods for agent-assisted medical procedures
US20070190165A1 (en) 2005-10-21 2007-08-16 Brey Eric M Tissue-specific basement membrane gels
US7892577B2 (en) 2006-02-27 2011-02-22 Globus Medical, Inc. Bone graft materials derived from mineralized gelatin
US8361503B2 (en) 2007-03-02 2013-01-29 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix-derived gels and related methods
US8187616B2 (en) 2007-05-29 2012-05-29 Trustees Of Tufts College Method for silk fibroin gelation using sonication
CA2654754A1 (en) * 2009-02-19 2010-08-19 Axcelon Biopolymers Corporation Anisotropic nanocomposite hydrogel
US20120020932A1 (en) 2010-07-02 2012-01-26 Zimmer Orthobiologics, Inc. Thermosensitive hydrogel composition and method
EP2726056A4 (en) * 2011-06-28 2015-01-14 Veris Medical Inc SYSTEM AND METHOD FOR COLLAGEN INSULATION
US20150165091A1 (en) 2012-03-30 2015-06-18 University Of Rochester Controlling extracellular matrix protein microstructure with ultrasound
EP2968417A4 (en) * 2013-03-15 2016-09-14 Univ Leland Stanford Junior INJECTABLE COMPOSITION FOR IN-SITU REPAIR AND RE-GENERATION OF INJURED TAPES OR TONES AND METHODS OF USE
US9861662B2 (en) 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
ITMI20131924A1 (it) 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
AU2015231110B2 (en) 2014-03-21 2019-03-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
WO2015164728A1 (en) 2014-04-24 2015-10-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fractionating extracellular matrix to modulate bioactivity and the host response
EP3319653A4 (en) 2015-07-10 2019-03-27 University of Pittsburgh - Of the Commonwealth System of Higher Education METHOD FOR PRODUCING ECM EQUIPMENT AND HYDROGELS FROM COLON
EP3349814B1 (en) 2015-09-18 2021-03-17 University of Pittsburgh- Of the Commonwealth System of Higher Education Non-gelling soluble extracellular matrix with biological activity
CA3011294A1 (en) 2016-01-13 2017-07-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vascular extracellular matrix hydrogel
JP2019513038A (ja) 2016-03-14 2019-05-23 リージェンティーズ コーポレイション 炎症性腸疾患を処置するための方法および組成物
CN106390188A (zh) * 2016-04-01 2017-02-15 浙江理工大学 一种具有创面修复功效的水凝胶及其制备方法
JP2019520822A (ja) 2016-06-16 2019-07-25 アスペクト バイオシステムズ リミティド バイオ印刷された半月板移植片及びその使用方法
EP3500193A4 (en) 2016-08-19 2020-04-08 Regentys Corporation EXTRACELLULAR MATRIX FOR TISSUE RECONSTRUCTION OF MUCOUS TISSUE
CA3049990A1 (en) 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer
EP3589292B1 (en) 2017-03-02 2023-08-23 University of Pittsburgh - Of the Commonwealth System of Higher Education Ecm hydrogel for treating esophageal inflammation
US11389569B2 (en) 2017-04-03 2022-07-19 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler
CN108295311A (zh) 2018-03-07 2018-07-20 南京市第医院 一种温敏型肾脏细胞外基质水凝胶的制备方法
CN115671410B (zh) 2018-06-21 2024-06-18 联邦高等教育系统匹兹堡大学 膀胱ecm水凝胶作为食管粘膜下层流体垫的用途
CN115487364B (zh) 2018-06-21 2024-02-23 联邦高等教育系统匹兹堡大学 细胞外基质(ecm)水凝胶作为粘膜下流体垫
AU2019288586B2 (en) 2018-06-21 2024-06-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of an extracellular matrix (ECM) hydrogel as an esophageal submucosal fluid cushion

Also Published As

Publication number Publication date
CN113557040B (zh) 2023-05-05
US20250235580A1 (en) 2025-07-24
WO2020186082A1 (en) 2020-09-17
AU2026202523A1 (en) 2026-04-23
CN116510085B (zh) 2026-01-02
US20220143265A1 (en) 2022-05-12
CN113557040A (zh) 2021-10-26
CN116510085A (zh) 2023-08-01
JP2026062723A (ja) 2026-04-10
KR102930622B1 (ko) 2026-02-24
KR20260028187A (ko) 2026-03-03
US12263270B2 (en) 2025-04-01
JP2022524380A (ja) 2022-05-02
AU2020235627A1 (en) 2021-08-19
KR20210142003A (ko) 2021-11-23
EP3937994A1 (en) 2022-01-19
AU2020235627B2 (en) 2026-01-08

Similar Documents

Publication Publication Date Title
US20250235580A1 (en) Acoustic extracellular matrix hydrogels and their use
JP7742172B2 (ja) 粘膜下流体クッションとしての細胞外マトリックス（ｅｃｍ）ヒドロゲル
JP7823916B2 (ja) 細胞外マトリックスに由来する最終滅菌ハイドロゲルまたはコロイド懸濁液の調製方法およびその使用
JP2024060075A (ja) 食道粘膜下流体クッションとしての細胞外マトリックス（ｅｃｍ）ヒドロゲルの使用
KR20210022717A (ko) 식도의 점막하 유체 쿠션으로 방광 ecm 하이드로겔의 사용
US20250228896A1 (en) Matrix bound nanovesicles encapsulated in hydrogels
JP2026074097A (ja) 細胞外マトリックスに由来する最終滅菌ハイドロゲルまたはコロイド懸濁液の調製方法およびその使用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20240311

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250211

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250211

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250211

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20250911

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20260106

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20260123

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20260123

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20260123

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260210

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260210