JP2022523763A - キメラ抗原受容体を発現する細胞とモノクローナル抗体との組み合わせを用いたがん免疫療法 - Google Patents

キメラ抗原受容体を発現する細胞とモノクローナル抗体との組み合わせを用いたがん免疫療法 Download PDF

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JP2022523763A
JP2022523763A JP2021547557A JP2021547557A JP2022523763A JP 2022523763 A JP2022523763 A JP 2022523763A JP 2021547557 A JP2021547557 A JP 2021547557A JP 2021547557 A JP2021547557 A JP 2021547557A JP 2022523763 A JP2022523763 A JP 2022523763A
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cells
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malignant
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cell
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マウリツ ダブリュー． ギアリングス
アンドレア ビオンディ
アレッサンドロ ランバルディ
ジュゼッペ ダストリ
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コイミューン インコーポレイテッド
フォンダツィオーネ マティルデ テッタマンティ エ メノッティ デ マルキ オンラス
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K39/001112—CD19 or B4
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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JP2021547557A 2019-02-13 2020-02-13 キメラ抗原受容体を発現する細胞とモノクローナル抗体との組み合わせを用いたがん免疫療法 Pending JP2022523763A (ja)

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US201962805052P 2019-02-13 2019-02-13
US62/805,052 2019-02-13
PCT/US2020/018127 WO2020168090A1 (en) 2019-02-13 2020-02-13 Cancer immunotherapy using combinations of cells expressing chimeric antigen receptors and monoclonal antibodies

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JP2022523763A true JP2022523763A (ja) 2022-04-26
JP2022523763A5 JP2022523763A5 (https=) 2023-02-20

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US (1) US20220168343A1 (https=)
EP (1) EP3924372A4 (https=)
JP (1) JP2022523763A (https=)
KR (1) KR20210131365A (https=)
AU (1) AU2020221271A1 (https=)
CA (1) CA3127142A1 (https=)
WO (1) WO2020168090A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524700A (ja) * 2002-05-02 2005-08-18 ワイス・ホールディングズ・コーポレイション カリチェアミシン誘導体−キャリアコンジュゲート
JP2013126979A (ja) * 2011-12-16 2013-06-27 Pfizer Inc 癌の処置のためのイノツズマブオゾガマイシンおよびトーリセルの組合わせ
JP2018518939A (ja) * 2015-04-08 2018-07-19 ノバルティス アーゲー Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
JP2018522833A (ja) * 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． キメラ抗原受容体（ｃａｒ）コンストラクト、及びｃａｒコンストラクトを発現するｔ細胞（ｃａｒ−ｔ）またはｎｋ細胞（ｃａｒ−ｎｋ）による疾患治療

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2878449T3 (es) * 2014-07-24 2021-11-18 2Seventy Bio Inc Receptores antigénicos quiméricos de BCMA

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524700A (ja) * 2002-05-02 2005-08-18 ワイス・ホールディングズ・コーポレイション カリチェアミシン誘導体−キャリアコンジュゲート
JP2013126979A (ja) * 2011-12-16 2013-06-27 Pfizer Inc 癌の処置のためのイノツズマブオゾガマイシンおよびトーリセルの組合わせ
JP2018518939A (ja) * 2015-04-08 2018-07-19 ノバルティス アーゲー Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
JP2018522833A (ja) * 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． キメラ抗原受容体（ｃａｒ）コンストラクト、及びｃａｒコンストラクトを発現するｔ細胞（ｃａｒ−ｔ）またはｎｋ細胞（ｃａｒ−ｎｋ）による疾患治療

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BHOJWANI, D. ET AL., LEUKEMIA, vol. 33, JPN6024008043, 28 September 2018 (2018-09-28), pages 884 - 892, ISSN: 0005473046 *
SHOR, B. ET AL., MOL IMMUNOL, vol. 67, JPN6024047997, 2015, pages 107 - 116, ISSN: 0005473047 *

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CA3127142A1 (en) 2020-08-20
EP3924372A4 (en) 2023-02-22
KR20210131365A (ko) 2021-11-02
AU2020221271A1 (en) 2021-10-07
EP3924372A1 (en) 2021-12-22
WO2020168090A1 (en) 2020-08-20
US20220168343A1 (en) 2022-06-02

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