JP2022522312A5 - - Google Patents

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Publication number
JP2022522312A5
JP2022522312A5 JP2021559054A JP2021559054A JP2022522312A5 JP 2022522312 A5 JP2022522312 A5 JP 2022522312A5 JP 2021559054 A JP2021559054 A JP 2021559054A JP 2021559054 A JP2021559054 A JP 2021559054A JP 2022522312 A5 JP2022522312 A5 JP 2022522312A5
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JP
Japan
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unsubstituted
substituted
alkyl
monocyclic
group
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JP2021559054A
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English (en)
Japanese (ja)
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JP2022522312A (ja
JP7627008B2 (ja
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Priority claimed from PCT/US2020/026116 external-priority patent/WO2020205934A1/en
Publication of JP2022522312A publication Critical patent/JP2022522312A/ja
Publication of JP2022522312A5 publication Critical patent/JP2022522312A5/ja
Priority to JP2024101773A priority Critical patent/JP7710215B2/ja
Application granted granted Critical
Publication of JP7627008B2 publication Critical patent/JP7627008B2/ja
Priority to JP2025110439A priority patent/JP7811768B2/ja
Active legal-status Critical Current
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JP2021559054A 2019-04-03 2020-04-01 ピロール化合物 Active JP7627008B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024101773A JP7710215B2 (ja) 2019-04-03 2024-06-25 ピロール化合物
JP2025110439A JP7811768B2 (ja) 2019-04-03 2025-06-30 ピロール化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962828919P 2019-04-03 2019-04-03
US62/828,919 2019-04-03
US201962932686P 2019-11-08 2019-11-08
US62/932,686 2019-11-08
PCT/US2020/026116 WO2020205934A1 (en) 2019-04-03 2020-04-01 Pyrrole compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024101773A Division JP7710215B2 (ja) 2019-04-03 2024-06-25 ピロール化合物

Publications (3)

Publication Number Publication Date
JP2022522312A JP2022522312A (ja) 2022-04-15
JP2022522312A5 true JP2022522312A5 (https=) 2023-04-11
JP7627008B2 JP7627008B2 (ja) 2025-02-05

Family

ID=72667046

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021559054A Active JP7627008B2 (ja) 2019-04-03 2020-04-01 ピロール化合物
JP2024101773A Active JP7710215B2 (ja) 2019-04-03 2024-06-25 ピロール化合物
JP2025110439A Active JP7811768B2 (ja) 2019-04-03 2025-06-30 ピロール化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024101773A Active JP7710215B2 (ja) 2019-04-03 2024-06-25 ピロール化合物
JP2025110439A Active JP7811768B2 (ja) 2019-04-03 2025-06-30 ピロール化合物

Country Status (22)

Country Link
US (3) US11191747B2 (https=)
EP (2) EP3947349B1 (https=)
JP (3) JP7627008B2 (https=)
KR (2) KR102933784B1 (https=)
CN (4) CN114258391A (https=)
AU (2) AU2020253444C1 (https=)
BR (1) BR112021019817A2 (https=)
CA (1) CA3134635A1 (https=)
CL (1) CL2021002575A1 (https=)
CO (1) CO2021014210A2 (https=)
DK (1) DK3947349T3 (https=)
FI (1) FI3947349T3 (https=)
GE (2) GEAP202515762A (https=)
IL (1) IL286902B2 (https=)
MA (1) MA55564A (https=)
MX (1) MX2021012105A (https=)
PE (1) PE20220252A1 (https=)
PH (1) PH12021552513A1 (https=)
SG (1) SG11202110718PA (https=)
TW (1) TWI846853B (https=)
UA (1) UA129029C2 (https=)
WO (1) WO2020205934A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021012105A (es) 2019-04-03 2021-11-03 Aligos Therapeutics Inc Compuestos de pirrol.
CN114685514A (zh) * 2020-12-29 2022-07-01 广东东阳光药业有限公司 新型酰胺吡咯类化合物及其在药物中的应用
WO2022156758A1 (zh) * 2021-01-22 2022-07-28 广东东阳光药业有限公司 新型酰胺吡咯类化合物及其在药物中的用途
EP4399217A2 (en) 2021-09-08 2024-07-17 Aligos Therapeutics, Inc. Modified short interfering nucleic acid (sina) molecules and uses thereof
CN118974014B (zh) * 2022-03-17 2026-01-27 成都微芯药业有限公司 吡咯酰胺类化合物及其制备方法和用途
CN116120219A (zh) * 2022-12-27 2023-05-16 吉斯凯(苏州)制药有限公司 一种多取代吡咯类化合物及其制备方法和在制备hbv衣壳蛋白抑制剂中的应用
EP4654973A1 (en) * 2023-01-26 2025-12-03 Aligos Therapeutics, Inc. Hepatitis b combination therapies

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784782A (en) 1986-03-27 1988-11-15 The Lubrizol Corporation Heterocyclic compounds useful as additives for lubricant and fuel compositions
HUP0302918A2 (hu) 2000-07-17 2003-12-29 Ranbaxy Laboratories Limited Mikrobaellenes oxazolidinonszármazékok és a vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására
ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
GB0119172D0 (en) 2001-08-06 2001-09-26 Melacure Therapeutics Ab Phenyl pyrrole derivatives
PL377314A1 (pl) 2002-12-20 2006-01-23 Amgen Inc. Modulatory astmy i zapaleń na tle alergicznym
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
GB2398299A (en) 2003-02-13 2004-08-18 Melacure Therapeutics Ab Pharmaceutically active phenyl-pyrrole derivatives
US20070191336A1 (en) 2003-12-24 2007-08-16 Flynn Daniel L Anti-inflammatory medicaments
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN100519555C (zh) 2004-03-13 2009-07-29 Tmrc株式会社 将dna的特定碱基序列烷基化的新吲哚衍生物和使用其的烷基化剂以及药剂
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20060105355A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer having a linker moiety
WO2006092059A1 (en) 2005-03-04 2006-09-08 Fan Wu Design and synthesis of novel antimicrobials
US20100234379A1 (en) 2005-07-28 2010-09-16 Bahr Ben A Dual modulation of endocannabinoid transport and fatty-acid amide hydrolase for treatment of excitotoxicity
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
ES2565683T3 (es) 2006-09-15 2016-04-06 Xcovery, Inc. Compuestos inhibidores de quinasa
CA2688136A1 (en) 2007-06-08 2008-12-11 Advinus Therapeutics Private Limited Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application
AU2008266515B2 (en) 2007-06-18 2014-05-01 Sanofi Pyrrole derivatives as P2Y12 antagonists
CA2754492A1 (en) 2009-03-05 2010-09-10 Purdue Research Foundation Method for early imaging of atherosclerosis
EP2408770B1 (en) 2009-03-20 2014-11-05 University Of Virginia Patent Foundation Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
JP2013508413A (ja) 2009-10-22 2013-03-07 ヴァンダービルト ユニバーシティー mGluR4アロステリック増強剤、組成物、および神経機能不全を治療する方法
EP2568809A4 (en) 2010-05-12 2013-11-06 Univ Vanderbilt HETEROCYCLIC ALLOSTERE SULFON MGLUR4 POTENTIATORS, COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS
CN103068814B (zh) 2010-06-15 2015-11-25 拜耳知识产权有限责任公司 邻氨基苯甲酸衍生物
PL2616444T3 (pl) 2010-09-14 2016-04-29 Inst Biochemii I Biofizyki Pan Związki będące modulatorami zmutowanego białka CFTR oraz ich zastosowanie w leczeniu chorób związanych z zaburzeniami w funkcjonowaniu białka CFTR
WO2012047525A2 (en) 2010-09-27 2012-04-12 Endocyte, Inc. Folate conjugates for treating inflammation of the eye
WO2012078902A2 (en) 2010-12-08 2012-06-14 Proteostasis Therapeutics, Inc. Proteostasis regulators
WO2012087976A2 (en) 2010-12-21 2012-06-28 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
WO2012154880A1 (en) 2011-05-09 2012-11-15 Proteostasis Therapeutics, Inc. Proteostasis regulators for treating cystic fibrosis and other protein misfolding diseases
US20130072473A1 (en) 2011-05-09 2013-03-21 Proteostasis Therapeutics, Inc. Compounds for treating protein folding disorders
HUE044867T2 (hu) 2011-05-12 2019-11-28 Proteostasis Therapeutics Inc Proteosztázis szabályzók
JP5977347B2 (ja) 2011-07-01 2016-08-24 バルーク エス.ブルームバーグ インスティテュート Hbv感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体
US8835640B1 (en) 2011-11-16 2014-09-16 Paresh T. Gandhi Nicotine derivatives
EP2804605A4 (en) 2012-01-20 2015-07-08 Acucela Inc SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASES
EP3345597A3 (en) 2012-09-19 2018-08-22 Faller & Williams Technology, LLC Pkc delta inhibitors for use as therapeutics
TWI733288B (zh) 2013-05-17 2021-07-11 愛爾蘭商健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療b型肝炎藥物的用途
HRP20180791T1 (hr) * 2013-07-25 2018-09-07 Janssen Sciences Ireland Uc Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b
CA2923712C (en) * 2013-10-23 2021-11-02 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
CN104672221B (zh) 2013-11-29 2018-01-23 中国科学院上海有机化学研究所 一种氟代苯并杂环‑杂芳环结构的合成方法
US10040780B2 (en) 2014-03-03 2018-08-07 The Regents Of The University Of California Mcl-1 antagonists
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
US20160166679A1 (en) 2014-12-12 2016-06-16 Purdue Research Foundation Method of treatment using folate conjugates and tyrosine kinase inhibitors
KR101726059B1 (ko) 2015-07-28 2017-04-12 한양대학교 산학협력단 디피롤 유도체와 암모늄 염을 포함하는 브롬화수소 가스 검출용 조성물 및 이를 포함하는 브롬화수소 가스 검출용 색변환 센서
KR101726060B1 (ko) 2015-07-28 2017-04-12 한양대학교 산학협력단 디피롤 유도체와 금속 염을 포함하는 염화수소 가스 검출용 조성물 및 이를 포함하는 염화수소 가스 검출용 색변환 센서
WO2017081615A1 (en) 2015-11-09 2017-05-18 Wockhardt Limited 7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections
CO2018009382A2 (es) * 2016-03-09 2018-09-20 Univ Emory Eliminación del virus de la hepatitis b con agentes antivirales
JOP20190024A1 (ar) * 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CN108250121A (zh) 2016-12-28 2018-07-06 上海长森药业有限公司 磺酰胺-芳基酰胺类化合物及其治疗乙型肝炎的药物用途
WO2019185016A1 (zh) * 2018-03-30 2019-10-03 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
US20230056135A1 (en) 2018-10-05 2023-02-23 Emory University Monomer and multimeric anti-hbv agents
WO2020169784A1 (en) 2019-02-22 2020-08-27 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases
MX2021012105A (es) 2019-04-03 2021-11-03 Aligos Therapeutics Inc Compuestos de pirrol.
EP4245372A3 (en) 2019-11-13 2023-11-22 Xi'An Xintong Pharmaceutical Research Co., Ltd. Hbv inhibitor and use thereof
CN114685514A (zh) 2020-12-29 2022-07-01 广东东阳光药业有限公司 新型酰胺吡咯类化合物及其在药物中的应用

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