JP2022520285A5 - - Google Patents
Info
- Publication number
- JP2022520285A5 JP2022520285A5 JP2021548250A JP2021548250A JP2022520285A5 JP 2022520285 A5 JP2022520285 A5 JP 2022520285A5 JP 2021548250 A JP2021548250 A JP 2021548250A JP 2021548250 A JP2021548250 A JP 2021548250A JP 2022520285 A5 JP2022520285 A5 JP 2022520285A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- immune response
- hres
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1902277.1 | 2019-02-19 | ||
| GBGB1902277.1A GB201902277D0 (en) | 2019-02-19 | 2019-02-19 | Therapeutic agents |
| PCT/GB2020/050401 WO2020169974A1 (en) | 2019-02-19 | 2020-02-19 | Hypoxia-responsive chimeric antigen receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022520285A JP2022520285A (ja) | 2022-03-29 |
| JP2022520285A5 true JP2022520285A5 (https=) | 2023-02-28 |
| JP7684692B2 JP7684692B2 (ja) | 2025-05-28 |
Family
ID=65998727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021548250A Active JP7684692B2 (ja) | 2019-02-19 | 2020-02-19 | 低酸素応答性キメラ抗原受容体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220195009A1 (https=) |
| EP (1) | EP3927734A1 (https=) |
| JP (1) | JP7684692B2 (https=) |
| KR (1) | KR20210132105A (https=) |
| CN (1) | CN113710695A (https=) |
| AU (1) | AU2020224373B2 (https=) |
| BR (1) | BR112021016435A2 (https=) |
| CA (1) | CA3130688A1 (https=) |
| GB (1) | GB201902277D0 (https=) |
| IL (1) | IL285587A (https=) |
| WO (1) | WO2020169974A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3922721A4 (en) * | 2019-03-12 | 2023-01-11 | Chongqing Precision Biotech Company Limited | PROMOTER REGULATED BY HYPOXIA AND ITS APPLICATION |
| JP2024530215A (ja) * | 2021-08-13 | 2024-08-16 | 上海▲シン▼湾生物科技有限公司 | 低酸素トリガーの人工転写因子、転写制御システム及びその応用 |
| US20250319126A1 (en) * | 2021-10-29 | 2025-10-16 | Shanghai Sinobay Biotechnology Co., Ltd. | Condition-controlled spliceable chimeric antigen receptor molecule and application thereof |
| CN114149510B (zh) * | 2021-10-29 | 2024-01-30 | 上海鑫湾生物科技有限公司 | 一种条件控制的可剪接嵌合抗原受体分子及其应用 |
| US20230227779A1 (en) * | 2022-01-19 | 2023-07-20 | Innovative Cellular Therapeutics Holdings, Ltd. | Enhanced Chimeric Antigen Receptor Cells in Hypoxic Tumor Microenvironment |
| WO2025016333A1 (zh) * | 2023-07-14 | 2025-01-23 | 广州百吉生物制药有限公司 | 一种工程化免疫细胞及其制备和应用 |
| WO2025255080A1 (en) * | 2024-06-04 | 2025-12-11 | The Children's Hospital Of Philadelphia | Hypoxia inducible high-fidelity circuit |
| WO2026016166A1 (zh) * | 2024-07-19 | 2026-01-22 | 上海鑫湾生物科技有限公司 | 一种响应缺氧环境的差异化基因表达调控系统及其应用 |
| CN119491023A (zh) * | 2024-12-03 | 2025-02-21 | 北京再生世纪生物科技有限公司 | 一种基因修饰增强脐带间充质干细胞旁分泌功能的方法及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| JP2002526083A (ja) * | 1998-09-23 | 2002-08-20 | オックスフォード バイオメディカ（ユーケイ）リミテッド | ポリヌクレオチド構築物およびその使用 |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| US9738907B2 (en) * | 2002-02-01 | 2017-08-22 | Oxford Biomedica (Uk) Limited | Viral vector |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| GB0816096D0 (en) | 2008-09-04 | 2008-10-15 | Medigene Ltd | Diabetes t cell receptors |
| GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| GB0911566D0 (en) | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
| BR112013003647A2 (pt) | 2010-07-28 | 2017-11-07 | Immunocore Ltd | receptores de células t. |
| KR101232123B1 (ko) * | 2010-10-08 | 2013-02-12 | 연세대학교 산학협력단 | 재조합된 유전자발현 조절서열을 가지는 종양 특이적 발현이 개선된 유전자 전달체 |
| MX2014001222A (es) | 2011-07-29 | 2014-09-15 | Univ Pennsylvania | Receptores coestimuladores de cambio. |
| WO2013041865A1 (en) | 2011-09-22 | 2013-03-28 | Immunocore Limited | T cell receptors |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| MX370148B (es) | 2012-10-02 | 2019-12-03 | Memorial Sloan Kettering Cancer Center | Composiciones y su uso para inmunoterapia. |
| PL3360964T3 (pl) | 2012-12-06 | 2020-03-31 | Sigma-Aldrich Co. Llc | Modyfikacja i regulacja genomu oparta na crispr |
| CN113355357B (zh) | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| ES2671004T3 (es) * | 2013-03-07 | 2018-06-04 | Baylor College Of Medicine | Dirección a CD138 en cáncer |
| WO2015092024A2 (en) * | 2013-12-20 | 2015-06-25 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
| WO2016146819A1 (en) * | 2015-03-18 | 2016-09-22 | Apceth Gmbh & Co. Kg | Hypoxia-induced expression of therapeutic proteins in mesenchymal stem cells |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| GB201522592D0 (en) | 2015-12-22 | 2016-02-03 | Immunocore Ltd | T cell receptors |
| GB201604953D0 (en) | 2016-03-23 | 2016-05-04 | Immunocore Ltd | T cell receptors |
| GB201709866D0 (en) | 2017-06-20 | 2017-08-02 | Immunocore Ltd | T cell receptors |
| CN109280086B (zh) * | 2018-09-10 | 2021-03-16 | 上海市公共卫生临床中心 | 一种肿瘤微环境特异性活化的缺氧诱导型嵌合抗原受体 |
-
2019
- 2019-02-19 GB GBGB1902277.1A patent/GB201902277D0/en not_active Ceased
-
2020
- 2020-02-19 EP EP20708568.9A patent/EP3927734A1/en active Pending
- 2020-02-19 KR KR1020217030111A patent/KR20210132105A/ko not_active Withdrawn
- 2020-02-19 JP JP2021548250A patent/JP7684692B2/ja active Active
- 2020-02-19 BR BR112021016435A patent/BR112021016435A2/pt not_active Application Discontinuation
- 2020-02-19 US US17/431,859 patent/US20220195009A1/en active Pending
- 2020-02-19 AU AU2020224373A patent/AU2020224373B2/en active Active
- 2020-02-19 CA CA3130688A patent/CA3130688A1/en active Pending
- 2020-02-19 WO PCT/GB2020/050401 patent/WO2020169974A1/en not_active Ceased
- 2020-02-19 CN CN202080029850.8A patent/CN113710695A/zh active Pending
-
2021
- 2021-08-12 IL IL285587A patent/IL285587A/en unknown
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