JP2022519263A - 光防御用植物由来組成物 - Google Patents
光防御用植物由来組成物 Download PDFInfo
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- JP2022519263A JP2022519263A JP2021544845A JP2021544845A JP2022519263A JP 2022519263 A JP2022519263 A JP 2022519263A JP 2021544845 A JP2021544845 A JP 2021544845A JP 2021544845 A JP2021544845 A JP 2021544845A JP 2022519263 A JP2022519263 A JP 2022519263A
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Abstract
Description
本願は、参照によりその全体が本明細書に組み込まれる、2019年2月7日出願の米国仮特許出願第62/802,219号について、優先権に基づく権利を主張するものである。
本発明は、そのいくつかの実施形態において、光防御、特に植物材料から得られ得るUV防止用の組成物に関するが、これらに限定されるものではない。
本発明の実施形態の一態様においては、UV吸収性材料と、皮膚医学的に許容される担体とを含み、UV吸収性材料がウルシの葉および/または未熟果の抽出物である組成物が提供される。
本発明の実施形態の一態様においては、UV吸収性材料(例:本明細書に記載した、任意の対応する実施形態に基づくUV吸収性材料)をウルシから得るための方法が提供される。方法は、ウルシの葉および/または未熟果を水混和性有機溶媒と接触させる工程を含む(例えば、UV吸収性材料を抽出物として得る)。いくつかの実施形態において、方法は、例えば、溶媒の蒸発によって、水混和性有機溶媒を除去する工程をさらに含む。
本明細書において上述したように、本明細書に示す任意の実施形態におけるUV吸収性材料は、皮膚医学的に許容される担体を含む組成物の一部として活用することができる。
材料:
DMEM(100単位/mlのペニシリンおよび100μg/mlのストレプトマイシンを添加したダルベッコの変法イーグル培地)はBiological Industries社(イスラエル国)より入手した。
DPPH(ジフェニルピクリルヒドラジル)はSigma Aldrich社より入手した。
エタノールはMercury Scientific & Industrial Products Ltd.より入手した。
メタノールはMercury Scientific & Industrial Products Ltd.より入手した。
MTT(臭化3-(4,5-ジメチルチアゾリ-2-イル)-2,5-ジフェニルテトラゾリウム)はSigma Aldrich社より入手した。
Dutra et al.[Braz J Pharma Sci 2004, 40:381-385]に記載の手順に従い、OptLab(商標)Xソフトウエア(Ascanis社)を使用してマンスール式を用いてSPF(紫外線防御指数)値を計算するために、吸収スペクトルを用いた。
HPLC(高速液体クロマトグラフィー)のクロマトグラムは、次のようにして得た。2度蒸留した水:メタノール比が95:5の混合物で試料を濃度0.01mg/mlに希釈し、光ダイオードアレイ検出器を備えたWaters社のHPLC装置のRP-18カラムに10μlをロードし、96%のトリフルオロ酢酸(0.1%)水溶液から100%アセトニトリルの勾配を流速1ml/分で使用した。
インフォームドコンセントへの署名後に、腹部美容整形手術を受ける30~60歳の健康な女性から、許可を得て皮膚を採取した。Portugal-Cohen et al.[Exp Dermatol 2011, 20:749-755]に記載の手順に従って0.8×0.8cm2の切片に皮膚を切り出すために機械的皮膚プレスを用いた。Portugal-Cohen et al.[Exp Dermatol 2011, 20:749-755]およびCohen et al.[Dead Sea and Arava Studies 2015, 7:66-74]に記載の手順に従い、真皮側が培地に浸漬するように、皮膚移植片を空気/液体界面に維持した。100単位/mlのペニシリンおよび100μg/mlのストレプトマイシンを添加したDMEM(ダルベッコの変法イーグル培地)を含む6穴培養プレートに、ヒト皮膚移植片を、真皮側が下で表皮が上になるように加えた。全ての試料を一晩の回復期後に使用した。
UV防除能を有する植物のスクリーニング
種々の植物のUVB防除能をスクリーニングするために、ユダヤの砂漠に生息する伝統的に使用されているハーブについて大規模スクリーニングを実施した。各試験植物の葉、小枝、枝、果実および根を回収、乾燥、粉砕し、ソクスレーシステムを使用して個別にエタノール、水、クロロフォルムまたは酢酸プロピレングリコールメチルエーテル(PMA)で抽出した。真空下で溶媒を蒸発させた後、0.1グラムの粗抽出液を超音波を用いて等量の溶媒に再懸濁し、積分球なしのCary(商標)60デュアルビーム分光光度計(Agilent社)を用いたUV吸収スペクトル解析のために、既定の濃度に希釈した。
ウルシの葉からのUV防除物質の単離
上記実施例1に記載した種々のウルシの葉抽出物の内、最も効果的な抽出物(キルヤット・アルバ地方由来の試料)をいくつかの単離技術に付すことでさらに精製した。各工程の後には、本明細書において「SH-101」と称するUV吸収成分を単離するために、得られた画分をUV吸光度によって評価した。その純度は、本明細書において上述した手順に従い、HPLCで決定した。
ウルシの葉由来のUV防除物質(SH-401)の特徴付け
上記実施例2に記載した方法などを用いてSH-101をウルシの葉から単離した。精製SH-101をHPLCおよび他のスペクトル分析技術を用いて特徴づけた。
ウルシの葉由来のSH-401のヒト皮膚細胞に対する効果
活性化合物SH-401(実施例2の記載と同様に単離)の安全性と効能を探索するために、上記材料と方法の項に記載した手順に従って、ヒト皮膚移植片に対していくつかの実験を実施した。
皮膚老化および創傷治癒に対するSH-401の効果
SH-401の皮膚老化に対する効果を評価するために、皮膚老化および皴形成において影響を受ける、細胞外マトリックスバランスの次の2つの重要な因子を試験した:環境損傷に続くコラーゲン合成、およびコラーゲン分解のカギとなる酵素であるマトリックスメタロプロテイナーゼ-1(MMP1)の活性。
Claims (46)
- UV吸収性材料と、皮膚医学的に許容される担体とを含み、前記UV吸収性材料がウルシ(Rhus spp.)の葉および/または未熟果の抽出物であり、前記UV吸収性材料の組成物中の濃度が少なくとも0.005mg/mlである、日焼け止め組成物。
- 前記組成物中の前記UV吸収性材料の濃度が、波長300nmで路長1mmの照射の少なくとも90%を吸収するのに十分な量である、請求項1に記載の組成物。
- 前記ウルシがRhus coriariaを含む、請求項1に記載の組成物。
- 前記UV吸収性材料が、複数のガロイル置換基の結合したグルコース部分を有する化合物を少なくとも1種含む、請求項1~3のいずれか一項に記載の組成物。
- 少なくとも1種の前記化合物が1,2,3,4,6-ペンタガロイルグルコースを含む、請求項4に記載の組成物。
- 前記UV吸収性材料が、前記ウルシの葉および/または未熟果と水混和性有機溶媒とを接触させ、前記水混和性有機溶媒を除去して、UV吸収性材料を得ることを含む方法によって得られ得るものである、請求項1~5のいずれか一項に記載の組成物。
- 前記水混和性有機溶媒がC1-4アルコールを含む、請求項6に記載の組成物。
- 前記水混和性有機溶媒がエタノール、アセトンおよび/またはグリセリンを含む、請求項7に記載の組成物。
- 前記接触が、ソックスレー抽出器を用いて実施する抽出を含む、請求項6~8のいずれか一項に記載の組成物。
- 前記接触が、前記ウルシの葉および/または未熟果の乾燥重量1g当たり5~40mlの前記水混和性有機溶媒の比率を用いて実施される、請求項6~9のいずれか一項に記載の組成物。
- 前記方法が、極性溶媒と非極性溶媒との間の前記UV吸収性材料の分配と、前記極性溶媒に分配される画分の回収とをさらに含む、請求項6~10のいずれか一項に記載の組成物。
- 前記非極性溶媒がアルカンを含む、請求項11に記載の組成物。
- 前記アルカンがヘキサンを含む、請求項12に記載の組成物。
- 前記極性溶媒が水を含む、請求項11~13のいずれか一項に記載の組成物。
- 前記方法が、前記極性溶媒に分配された画分の水と水不混和性極性有機溶媒との間の分配、および前記水不混和性極性有機溶媒に分配される画分の回収をさらに含む、請求項11~14のいずれか一項に記載の組成物。
- 前記水不混和性極性有機溶媒がエステルを含む、請求項15に記載の組成物。
- 前記エステルが酢酸エチルを含む、請求項16に記載の組成物。
- 前記方法が、前記水不混和性極性有機溶媒に分配される画分の水を含む溶媒との接触による、前記UV吸収性材料の結晶化をさらに含む、請求項15~17のいずれか一項に記載の組成物。
- 前記方法が、前記UV吸収性材料のカラムクロマトグラフィーによる精製をさらに含む、請求項6~18のいずれか一項に記載の組成物。
- ウルシ(Rhus spp.)の葉および/または未熟果から単離された1,2,3,4,6-ペンタガロイルグルコースと、皮膚医学的に許容される担体とを含み、前記1,2,3,4,6-ペンタガロイルグルコースの組成物中の濃度が少なくとも0.005mg/mlである、日焼け止め組成物。
- 前記組成物中のUV吸収性材料の濃度が、波長300nmで路長1mmの照射の少なくとも90%を吸収するのに十分な量である、請求項20に記載の組成物。
- ウルシ(Rhus spp.)の葉および/または未熟果から抽出されたUV吸収性材料と、皮膚医学的に許容される担体とを含む、医薬用または化粧用の組成物。
- 前記ウルシがRhus coriariaを含む、請求項22に記載の組成物。
- 複数のガロイル置換基の結合したグルコース部分を含む化合物を少なくとも1種含む、請求項22または23に記載の組成物。
- 少なくとも1種の前記化合物が1,2,3,4,6-ペンタガロイルグルコースを含む、請求項24に記載の組成物。
- 皮膚老化および創傷からなる群より選ばれる状態の治療用である、請求項22~25のいずれか一項に記載の組成物。
- 前記化粧用の組成物が、皮膚の若返り用組成物および/またはピーリング用組成物である、請求項22~25のいずれか一項に記載の組成物。
- UV吸収性材料を得るための方法であって、ウルシ(Rhuss spp.)の葉および/または未熟果と水混和性有機溶媒とを接触させ、前記水混和性有機溶媒を除去して、UV吸収性材料を得ることを含む方法。
- 前記水混和性有機溶媒がC1-4アルコールを含む、請求項28に記載の方法。
- 前記水混和性有機溶媒がエタノール、アセトンおよび/またはグリセリンを含む、請求項29に記載の方法。
- 前記接触が、ソックスレー抽出器を用いて実施する抽出を含む、請求項28~30のいずれか一項に記載の方法。
- 前記接触が、前記ウルシの葉および/または未熟果の乾燥重量1g当たり5~40mlの前記水混和性有機溶媒の比率を用いて実施される、請求項28~31のいずれか一項に記載の方法。
- 極性溶媒と非極性溶媒との間の前記UV吸収性材料の分配と、前記極性溶媒に分配された画分の回収とをさらに含む、請求項28~32のいずれか一項に記載の方法。
- 前記非極性溶媒がアルカンを含む、請求項33に記載の方法。
- 前記アルカンがヘキサンを含む、請求項34に記載の方法。
- 前記極性溶媒が水を含む、請求項33~35のいずれか一項に記載の方法。
- 前記極性溶媒に分配される画分の水と水不混和性極性有機溶媒との間の分配、および前記水不混和性極性有機溶媒に分配される画分の回収をさらに含む、請求項33~36のいずれか一項に記載の方法。
- 前記水不混和性極性有機溶媒がエステルを含む、請求項37に記載の方法。
- 前記エステルが酢酸エチルを含む、請求項38に記載の方法。
- 前記水不混和性極性有機溶媒に分配される画分の水を含む溶媒との接触による、前記UV吸収性材料の結晶化をさらに含む、請求項37~39のいずれか一項に記載の方法。
- 前記UV吸収性材料のカラムクロマトグラフィーによる精製をさらに含む、請求項28~40のいずれか一項に記載の方法。
- 前記ウルシがRhus coriariaを含む、請求項28~41のいずれか一項に記載の方法。
- 前記UV吸収性材料が、複数のガロイル置換基の結合したグルコース部分を有する化合物を少なくとも1種含む、請求項28~42のいずれか一項に記載の方法。
- 少なくとも1種の前記化合物が1,2,3,4,6-ペンタガロイルグルコースを含む、請求項43に記載の方法。
- 前記UV吸収性材料中の前記1,2,3,4,6-ペンタガロイルグルコースの純度が少なくとも95重量%である、請求項44に記載の方法。
- 請求項28~45のいずれか一項に記載の方法で得られたUV吸収性材料。
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