JP2022515376A5 - - Google Patents
Info
- Publication number
- JP2022515376A5 JP2022515376A5 JP2021534766A JP2021534766A JP2022515376A5 JP 2022515376 A5 JP2022515376 A5 JP 2022515376A5 JP 2021534766 A JP2021534766 A JP 2021534766A JP 2021534766 A JP2021534766 A JP 2021534766A JP 2022515376 A5 JP2022515376 A5 JP 2022515376A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- wetting agent
- water
- active compound
- acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18213115.1 | 2018-12-17 | ||
| EP18213115 | 2018-12-17 | ||
| PCT/EP2019/085255 WO2020126983A1 (en) | 2018-12-17 | 2019-12-16 | Methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate active compound product having improved properties, production and formulation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022515376A JP2022515376A (ja) | 2022-02-18 |
| JP2022515376A5 true JP2022515376A5 (enExample) | 2022-12-26 |
| JP7529667B2 JP7529667B2 (ja) | 2024-08-06 |
Family
ID=64744472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021534766A Active JP7529667B2 (ja) | 2018-12-17 | 2019-12-16 | 改善された特性を有するメチル｛４，６－ジアミノ－２－［５－フルオロ－１－（２－フルオロベンジル）－１ｈ－ピラゾロ［３，４－ｂ］ピリジン－３－イル］ピリミジン－５－イル｝カルバメート活性化合物生成物、その製造及び製剤化 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US12172996B2 (enExample) |
| EP (1) | EP3898624A1 (enExample) |
| JP (1) | JP7529667B2 (enExample) |
| KR (1) | KR102872983B1 (enExample) |
| CN (1) | CN113207290B (enExample) |
| AR (1) | AR116912A1 (enExample) |
| AU (1) | AU2019409269B2 (enExample) |
| BR (1) | BR112021009122A2 (enExample) |
| CL (1) | CL2021001580A1 (enExample) |
| CO (1) | CO2021007668A2 (enExample) |
| IL (1) | IL283976B2 (enExample) |
| JO (1) | JOP20210155B1 (enExample) |
| MX (1) | MX2021007090A (enExample) |
| PE (1) | PE20211593A1 (enExample) |
| SG (1) | SG11202104953VA (enExample) |
| TW (1) | TWI830835B (enExample) |
| UA (1) | UA129677C2 (enExample) |
| WO (1) | WO2020126983A1 (enExample) |
| ZA (1) | ZA202105021B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI830835B (zh) | 2018-12-17 | 2024-02-01 | 德商亞德維瑞醫藥有限公司 | 具改善性質之{4,6-二胺基-2-[5-氟-1-(2-氟芐基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯活性化合物產物、其製造及調配物 |
| WO2021156223A1 (en) | 2020-02-03 | 2021-08-12 | Adverio Pharma Gmbh | Nanoformulations of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate |
| EP3925953A1 (en) | 2020-06-16 | 2021-12-22 | Adverio Pharma GmbH | Process for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate |
| WO2025114276A1 (en) | 2023-12-01 | 2025-06-05 | Krka, D.D., Novo Mesto | Solid oral composition comprising vericiguat |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2745813B1 (fr) | 1996-03-07 | 1998-05-07 | Rhone Poulenc Chimie | Agglomerats spheriques d'acide 10-phenothiazinylpropanoique et leur procede de preparation |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| UY33041A (es) | 2009-11-27 | 2011-06-30 | Bayer Schering Pharma Aktienegesellschaft | Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico |
| DK3415515T3 (da) | 2009-11-27 | 2020-03-16 | Adverio Pharma Gmbh | Fremgangsmåde til fremstilling af methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamat |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| HUE053745T2 (hu) * | 2011-11-25 | 2021-07-28 | Adverio Pharma Gmbh | Helyettesített 5-fluor-1H-pirazolopiridin kristályos formában |
| CA2901636A1 (en) * | 2013-02-21 | 2014-08-28 | Adverio Pharma Gmbh | Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate |
| PL2792682T3 (pl) | 2013-04-19 | 2017-04-28 | Zach System | Sposób wytwarzania stałej postaci octanu abirateronu |
| WO2016113415A1 (en) * | 2015-01-16 | 2016-07-21 | Sandoz Ag | Process for the preparation of riociguat essentially free from genotoxic impurities |
| WO2017025981A1 (en) * | 2015-08-13 | 2017-02-16 | Msn Laboratories Private Limited | Process for the preparation of methyl 4,6-diamino-2-[l-(2-fhiorobenzvr)-lh-pyrazolo i3,4-blpvridin-3-vn-5-pyrimidinyl(methvl)carbamate and its polymorphs thereof |
| TWI830835B (zh) | 2018-12-17 | 2024-02-01 | 德商亞德維瑞醫藥有限公司 | 具改善性質之{4,6-二胺基-2-[5-氟-1-(2-氟芐基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯活性化合物產物、其製造及調配物 |
| EP3914588A1 (en) | 2019-01-22 | 2021-12-01 | Adverio Pharma GmbH | Process for manufacturing 4-(2,2,3,3-tetrafluoropropyl)morpholine |
| WO2021156223A1 (en) * | 2020-02-03 | 2021-08-12 | Adverio Pharma Gmbh | Nanoformulations of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate |
| EP3925953A1 (en) * | 2020-06-16 | 2021-12-22 | Adverio Pharma GmbH | Process for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate |
-
2019
- 2019-12-13 TW TW108145683A patent/TWI830835B/zh active
- 2019-12-16 BR BR112021009122-0A patent/BR112021009122A2/pt unknown
- 2019-12-16 SG SG11202104953VA patent/SG11202104953VA/en unknown
- 2019-12-16 EP EP19818086.1A patent/EP3898624A1/en active Pending
- 2019-12-16 JP JP2021534766A patent/JP7529667B2/ja active Active
- 2019-12-16 US US17/414,658 patent/US12172996B2/en active Active
- 2019-12-16 MX MX2021007090A patent/MX2021007090A/es unknown
- 2019-12-16 AU AU2019409269A patent/AU2019409269B2/en active Active
- 2019-12-16 IL IL283976A patent/IL283976B2/en unknown
- 2019-12-16 WO PCT/EP2019/085255 patent/WO2020126983A1/en not_active Ceased
- 2019-12-16 KR KR1020217018155A patent/KR102872983B1/ko active Active
- 2019-12-16 CN CN201980082044.4A patent/CN113207290B/zh active Active
- 2019-12-16 PE PE2021000859A patent/PE20211593A1/es unknown
- 2019-12-16 UA UAA202104115A patent/UA129677C2/uk unknown
- 2019-12-17 AR ARP190103698A patent/AR116912A1/es unknown
-
2021
- 2021-06-11 CO CONC2021/0007668A patent/CO2021007668A2/es unknown
- 2021-06-16 CL CL2021001580A patent/CL2021001580A1/es unknown
- 2021-06-16 JO JOJO/P/2021/0155A patent/JOP20210155B1/ar active
- 2021-07-16 ZA ZA2021/05021A patent/ZA202105021B/en unknown
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