JP2022514835A5 - - Google Patents

Info

Publication number
JP2022514835A5
JP2022514835A5 JP2021534266A JP2021534266A JP2022514835A5 JP 2022514835 A5 JP2022514835 A5 JP 2022514835A5 JP 2021534266 A JP2021534266 A JP 2021534266A JP 2021534266 A JP2021534266 A JP 2021534266A JP 2022514835 A5 JP2022514835 A5 JP 2022514835A5
Authority
JP
Japan
Prior art keywords
cysteine
insulin
acid
composition according
glutamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021534266A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022514835A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/KR2019/018320 external-priority patent/WO2020130751A1/ko
Publication of JP2022514835A publication Critical patent/JP2022514835A/ja
Publication of JP2022514835A5 publication Critical patent/JP2022514835A5/ja
Priority to JP2024147410A priority Critical patent/JP2024178193A/ja
Pending legal-status Critical Current

Links

JP2021534266A 2018-12-21 2019-12-23 インスリン及びグルカゴンを含む薬学組成物 Pending JP2022514835A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024147410A JP2024178193A (ja) 2018-12-21 2024-08-29 インスリン及びグルカゴンを含む薬学組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2018-0167798 2018-12-21
KR20180167798 2018-12-21
PCT/KR2019/018320 WO2020130751A1 (ko) 2018-12-21 2019-12-23 인슐린 및 글루카곤을 포함하는 약학 조성물

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024147410A Division JP2024178193A (ja) 2018-12-21 2024-08-29 インスリン及びグルカゴンを含む薬学組成物

Publications (2)

Publication Number Publication Date
JP2022514835A JP2022514835A (ja) 2022-02-16
JP2022514835A5 true JP2022514835A5 (https=) 2023-01-06

Family

ID=71102651

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021534266A Pending JP2022514835A (ja) 2018-12-21 2019-12-23 インスリン及びグルカゴンを含む薬学組成物
JP2024147410A Pending JP2024178193A (ja) 2018-12-21 2024-08-29 インスリン及びグルカゴンを含む薬学組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024147410A Pending JP2024178193A (ja) 2018-12-21 2024-08-29 インスリン及びグルカゴンを含む薬学組成物

Country Status (10)

Country Link
US (1) US20220064248A1 (https=)
EP (1) EP3900734A4 (https=)
JP (2) JP2022514835A (https=)
KR (1) KR20200078414A (https=)
CN (1) CN113365651A (https=)
AU (1) AU2019405389B2 (https=)
BR (1) BR112021011557A2 (https=)
CA (1) CA3124340A1 (https=)
MX (1) MX2021007124A (https=)
WO (1) WO2020130751A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113453703A (zh) * 2018-12-21 2021-09-28 韩美药品株式会社 包括胰岛素和对胰高血糖素和glp-1和gip受体均具有活性的三重激动剂的药物组合物
EP4183407A4 (en) * 2020-07-15 2024-08-14 Hanmi Pharm. Co., Ltd. THERAPEUTIC USE OF A GLUCAGNONE DERIVATIVE OR CONJUGATE THEREOF FOR LIVER DISEASES

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
US7314859B2 (en) * 2002-12-27 2008-01-01 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
AR081066A1 (es) * 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
KR20140043709A (ko) * 2011-01-20 2014-04-10 질랜드 파마 에이/에스 아실화 글루카곤 유사체와 인슐린 유사체의 조합
DK2963056T3 (da) 2013-02-26 2020-02-17 Hanmi Pharm Ind Co Ltd Insulinanalog og anvendelse deraf
AR100695A1 (es) * 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
WO2015189698A2 (en) 2014-06-08 2015-12-17 Beijing Cosci-Remd Bio Med Tech Company Ltd Methods for treating type 1 diabetes using glucagon receptor antagonistic antibodies
PE20171154A1 (es) * 2014-12-30 2017-08-16 Hanmi Pharm Ind Co Ltd Derivados de glucagon con estabilidad mejorada
EP4523705A3 (en) * 2015-06-30 2025-06-11 Hanmi Pharm. Co., Ltd. Glucagon derivative and a composition comprising a long acting conjugate of the same
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
WO2017052329A1 (en) * 2015-09-24 2017-03-30 Hanmi Pharm. Co., Ltd. Protein complex by use of a specific site of an immunoglobulin fragment for linkage
TW201718629A (zh) * 2015-09-25 2017-06-01 韓美藥品股份有限公司 包含多個生理多肽及免疫球蛋白Fc區之蛋白質接合物
EP3479841A4 (en) * 2016-06-29 2020-03-04 Hanmi Pharm. Co., Ltd. GLUCAGON DERIVATIVE, CONJUGATE THEREOF, COMPOSITION THEREOF AND THERAPEUTIC USE THEREOF
WO2018144867A1 (en) * 2017-02-03 2018-08-09 Vanderbilt University Systems, compositions and methods for treating diabetes
CN110545849A (zh) * 2017-02-03 2019-12-06 韩美药品株式会社 具有增加的持续性的生理活性物质的缀合物及其应用
GB201710822D0 (en) * 2017-07-05 2017-08-16 Zealand Pharma As Methods and medical uses relating to the treatment of hypoglycaemia

Similar Documents

Publication Publication Date Title
JP2019504055A5 (https=)
CN107106660B (zh) 长效glp-1/胰高血糖素受体双激动剂对于治疗非酒精性脂肪肝疾病的应用
JP6749845B2 (ja) インスリン及びglp−1/グルカゴン二重アゴニストを含む糖尿病治療用組成物
JP6877478B2 (ja) 増殖分化因子15(gdf−15)の構築物
JP2019524675A5 (https=)
TWI388570B (zh) 包含具有三個官能端的非肽醯聚合物的多肽複合物
JP7596268B2 (ja) グルカゴン、glp-1及びgip受容体の全てに活性を有する三重活性体と、インスリンとを含む薬学組成物
JP2021167352A (ja) 免疫グロブリンFcフラグメント結合を用いたタンパク質及びペプチドの溶解度を改善する方法
RU2009129953A (ru) Инсулинотропный комплекс, в котором использован фрагмент иммуноглобулина
JP2022551282A5 (https=)
EA038524B1 (ru) Длительно действующий конъюгат тройного агониста рецепторов глюкагона/glp 1/gip
CN107810202A (zh) 长效胰岛素或胰岛素类似物复合物
JP2022514835A5 (https=)
RU2015138536A (ru) Новый аналог инсулина и его применение
RU2016147505A (ru) Конъюгат, содержащий оксинтомодулин и фрагмент иммуноглобулина, и его применение
JP2016519569A5 (https=)
JP2015510880A5 (https=)
JP2020512287A5 (https=)
JP2024178193A (ja) インスリン及びグルカゴンを含む薬学組成物
IL293745A (en) Bifunctional molecules comprising an il-7 variant
RU2021116078A (ru) Фармацевтическая композиция, содержащая инсулин и глюкагон
RU2019131593A (ru) Комплекс аналога инсулина со сниженной аффинностью к инсулиновому рецептору и его применение
CN114984231B (zh) 稳定性制剂及其制备方法
RU2847194C1 (ru) Жидкая композиция длительно действующего конъюгата тройного агониста глюкагона, GLP-1 И GIP
RU2823246C2 (ru) Фармацевтическая композиция, содержащая инсулин и глюкагон