JP2022514264A5 - - Google Patents

Info

Publication number
JP2022514264A5
JP2022514264A5 JP2021534645A JP2021534645A JP2022514264A5 JP 2022514264 A5 JP2022514264 A5 JP 2022514264A5 JP 2021534645 A JP2021534645 A JP 2021534645A JP 2021534645 A JP2021534645 A JP 2021534645A JP 2022514264 A5 JP2022514264 A5 JP 2022514264A5
Authority
JP
Japan
Prior art keywords
disorder
pharmaceutical composition
composition according
anxiety
depression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021534645A
Other languages
English (en)
Japanese (ja)
Other versions
JP7487204B2 (ja
JP2022514264A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/066894 external-priority patent/WO2020131899A1/en
Publication of JP2022514264A publication Critical patent/JP2022514264A/ja
Publication of JP2022514264A5 publication Critical patent/JP2022514264A5/ja
Application granted granted Critical
Publication of JP7487204B2 publication Critical patent/JP7487204B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021534645A 2018-12-17 2019-12-17 有機化合物 Active JP7487204B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862780804P 2018-12-17 2018-12-17
US62/780,804 2018-12-17
PCT/US2019/066894 WO2020131899A1 (en) 2018-12-17 2019-12-17 Organic compound

Publications (3)

Publication Number Publication Date
JP2022514264A JP2022514264A (ja) 2022-02-10
JP2022514264A5 true JP2022514264A5 (enExample) 2022-12-23
JP7487204B2 JP7487204B2 (ja) 2024-05-20

Family

ID=71102816

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021534645A Active JP7487204B2 (ja) 2018-12-17 2019-12-17 有機化合物

Country Status (11)

Country Link
US (2) US12195462B2 (enExample)
EP (1) EP3898221A4 (enExample)
JP (1) JP7487204B2 (enExample)
KR (1) KR20210104785A (enExample)
CN (1) CN113423568A (enExample)
AU (1) AU2019403150B2 (enExample)
BR (1) BR112021011792A2 (enExample)
CA (1) CA3121635A1 (enExample)
IL (1) IL283961A (enExample)
MX (1) MX2021007217A (enExample)
WO (1) WO2020131899A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
EP3658144B1 (en) 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
JP7520013B2 (ja) 2018-12-17 2024-07-22 イントラ-セルラー・セラピーズ・インコーポレイテッド 置換複素環縮合γ-カルボリンの合成
JP7649743B2 (ja) 2018-12-21 2025-03-21 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
US12195463B2 (en) 2018-12-21 2025-01-14 Intra-Cellular Therapies, Inc. Organic compounds
WO2024173901A1 (en) * 2023-02-17 2024-08-22 Intra-Cellular Therapies, Inc. Lumateperone and derivatives thereof for modulating the nervous system
CN120192319B (zh) * 2023-12-22 2026-02-06 江苏恩华药业股份有限公司 一种卢美哌隆中间体化合物的制备方法
WO2026011166A1 (en) 2024-07-03 2026-01-08 Intra-Cellular Therapies, Inc. Substituted heterocycles for use in the treatment of diseases involving the 5-ht2a receptor

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238607A (en) 1972-06-19 1980-12-09 Endo Laboratories Inc. Pyridopyrrolo benzheterocycles
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
CH656884A5 (de) 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
ES2019275B3 (es) 1985-10-09 1991-06-16 Desitin Arzneimittel Gmbh Metodo para la produccion de una forma de administracion y de dosificacion para farmacos reactivos u otros principios activos.
HU208484B (en) 1988-08-17 1993-11-29 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition containing acid additional salt of selegilin as active component for treating schisofrenia
US5114976A (en) 1989-01-06 1992-05-19 Norden Michael J Method for treating certain psychiatric disorders and certain psychiatric symptoms
US5538739A (en) 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
CN1074923C (zh) 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
PT1140012E (pt) 1998-12-17 2004-05-31 Alza Corp Conversao de capsulas de gelatina cheias com liquido em sistemas de libertacao controlada por camadas multiplas
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
ATE277048T1 (de) 1999-06-15 2004-10-15 Bristol Myers Squibb Pharma Co Substituierte hetercyclisch kondensierte gamma carboline
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
US6849619B2 (en) 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
SK7042003A3 (en) 2000-12-20 2004-07-07 Bristol Myers Squibb Co Substituted pyridoindoles as serotonin agonists and antagonists
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US7592454B2 (en) 2004-04-14 2009-09-22 Bristol-Myers Squibb Company Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
US20080194592A1 (en) 2005-08-23 2008-08-14 Intra-Cellular Therapies, Inc. Organic Compounds
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
KR102107954B1 (ko) 2007-03-12 2020-05-07 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
NZ586963A (en) 2008-02-05 2012-11-30 Clera Inc Use of dopamine d2 receptor inhibitors for alleviating depression or improving cognition
AU2009223701B2 (en) 2008-03-12 2015-04-16 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines solid
EP3085231A1 (en) 2008-05-27 2016-10-26 Intra-Cellular Therapies, Inc. Method and compositions for sleep disorders and other disorders
CA2796756A1 (en) 2010-04-22 2011-10-27 Intra-Cellular Therapies, Inc. Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式-四氫-螺旋(環己烷-1,1’-吡啶[3,4-b]吲哚)-4-胺-衍生物
DE102010041942B4 (de) 2010-10-04 2013-01-17 Lear Corporation Bewegliche Kopfstützen für Fahrzeugsitze
EP3153149B1 (en) 2011-08-16 2018-04-11 Tosho, Inc. Tablet splitting apparatus
KR20140146192A (ko) 2012-04-14 2014-12-24 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
AR092568A1 (es) 2012-09-14 2015-04-22 Abbvie Deutschland Derivados triciclicos de quinolinas y de quinoxalinas
US9708322B2 (en) 2013-03-15 2017-07-18 Intra-Cellular Therapies, Inc. Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
CN105706016B (zh) 2013-09-11 2019-07-19 欧力天工美国公司 用于时钟同步的系统、方法和移动设备
KR102373288B1 (ko) 2013-12-03 2022-03-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
CA2944755A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
WO2015191554A1 (en) 2014-06-09 2015-12-17 Intra-Cellular Therapies, Inc. Compounds and methods of use to treat schizophrenia
WO2017117514A1 (en) 2015-12-31 2017-07-06 Tung Roger D Deuterated iti-007
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
US20200392135A1 (en) 2016-03-25 2020-12-17 Intra-Cellular Therapies, Inc. Organic compounds
DK3407889T3 (da) * 2016-03-25 2021-08-09 Intra Cellular Therapies Inc Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet
EP3436455A4 (en) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. NOVEL SALTS AND CRYSTALS
US11014925B2 (en) 2016-03-28 2021-05-25 Intra-Cellular Therapies, Inc. Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide
PL3497104T3 (pl) 2016-08-09 2022-02-21 Teva Pharmaceuticals International Gmbh Postacie w stanie stałym soli ditosylanowej lumateperonu
EP3562484B1 (en) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
ES2926533T3 (es) 2017-03-17 2022-10-26 Scripps Research Inst Antagonistas del receptor opioideo kappa y productos y métodos relacionados con los mismos
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
EP3658144B1 (en) 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy
WO2019023062A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
EP3801527B1 (en) 2018-06-08 2025-02-19 Intra-Cellular Therapies, Inc. Fused gamma-carbolines for acute treatment of anxiety or depression
EP3833346A4 (en) 2018-08-08 2022-08-03 Torralva Medical Therapeutics LLC Compositions for opiate and opioid prevention and reversal, and methods of their use
US12195463B2 (en) 2018-12-21 2025-01-14 Intra-Cellular Therapies, Inc. Organic compounds
JP7649743B2 (ja) 2018-12-21 2025-03-21 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
US10668097B1 (en) 2019-03-21 2020-06-02 Direct Digital, LLC Testosterone enhancing compositions and methods
CA3134674A1 (en) 2019-04-04 2020-10-08 Intra-Cellular Therapies, Inc. Methods of treating neuropathic pain
JP7397095B2 (ja) 2019-05-07 2023-12-12 ニーサム・ラボラトリーズ・インコーポレイテッド オピオイド受容体アンタゴニストプロドラッグ

Similar Documents

Publication Publication Date Title
JP2022514264A5 (enExample)
CN1832734B (zh) 用于治疗抑郁症的取代的2-氨基1,2,3,4-四氢化萘
JP2022515766A5 (enExample)
JP2005539068A5 (enExample)
TWI298255B (en) Use of optically pure (s.s)-reboxetine in the manufacture of a medicament for the treatment or prevention of fibromyalgia or another somatoform disorder
JP2021519267A5 (enExample)
JP2017509686A5 (enExample)
JP2013544850A5 (enExample)
KR20090029200A (ko) 우울증 질환에 대한 치료
US20040229943A1 (en) Analeptic and drug combinations
RU2020125170A (ru) Композиции и способы улучшения биодоступности 5-гидрокситриптофана
CA2511619A1 (en) Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders
JP2009542819A (ja) ムスカリン性受容体m1拮抗剤を使用する精神状態の処置
JP2007513052A5 (enExample)
JP2007513052A (ja) セロトニン再取り込み阻害剤およびアゴメラチンの併用。
ES2390225T3 (es) Combinación del analéptico modafinilo y de un antidepresivo para el tratamiento de la depresión
JP2018508556A5 (enExample)
US20040242698A1 (en) Analeptic and antidepressant combinations
CA2716966A1 (en) Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders
US20040229941A1 (en) Analeptic and antidepressant combinations
JP2011516604A (ja) 鬱病患者の自殺行動の予防治療のためのミルナシプラン塩酸塩の(1s,2r)鏡像異性体の使用
US20040229940A1 (en) Analeptic and antidepressant combinations
RU2021121046A (ru) Органическое соединение
CA2460348A1 (en) Methods of preparing and using 2-hydroxy derivatives of sibutramine and its metabolites
US20060217394A1 (en) Treatment of anhedonia