JP2022513199A - 操作されたチロシンアンモニアリアーゼ - Google Patents

操作されたチロシンアンモニアリアーゼ Download PDF

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Publication number
JP2022513199A
JP2022513199A JP2021533201A JP2021533201A JP2022513199A JP 2022513199 A JP2022513199 A JP 2022513199A JP 2021533201 A JP2021533201 A JP 2021533201A JP 2021533201 A JP2021533201 A JP 2021533201A JP 2022513199 A JP2022513199 A JP 2022513199A
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JP
Japan
Prior art keywords
lyase
seq
recombinant
tal
tyrosine ammonia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2021533201A
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English (en)
Japanese (ja)
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JP2022513199A5 (https=
Inventor
ジョイス リウ，
ニッキ デラス，
スティーブン ジェンヌ，
Original Assignee
コデクシス， インコーポレイテッド
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Application filed by コデクシス， インコーポレイテッド filed Critical コデクシス， インコーポレイテッド
Publication of JP2022513199A publication Critical patent/JP2022513199A/ja
Publication of JP2022513199A5 publication Critical patent/JP2022513199A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/225—Tyrosine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01023—Tyrosine ammonia-lyase (4.3.1.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021533201A 2018-12-14 2019-12-06 操作されたチロシンアンモニアリアーゼ Pending JP2022513199A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779647P 2018-12-14 2018-12-14
US62/779,647 2018-12-14
PCT/US2019/064891 WO2020123286A1 (en) 2018-12-14 2019-12-06 Engineered tyrosine ammonia lyase

Publications (2)

Publication Number Publication Date
JP2022513199A true JP2022513199A (ja) 2022-02-07
JP2022513199A5 JP2022513199A5 (https=) 2022-10-20

Family

ID=71073423

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021533201A Pending JP2022513199A (ja) 2018-12-14 2019-12-06 操作されたチロシンアンモニアリアーゼ

Country Status (8)

Country Link
US (3) US11473077B2 (https=)
EP (1) EP3893860A4 (https=)
JP (1) JP2022513199A (https=)
AU (1) AU2019397401A1 (https=)
CA (1) CA3122524A1 (https=)
IL (1) IL283894A (https=)
SG (1) SG11202105668PA (https=)
WO (1) WO2020123286A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3122524A1 (en) * 2018-12-14 2020-06-18 Codexis, Inc. Engineered tyrosine ammonia lyase
GB202009251D0 (en) 2020-06-17 2020-07-29 Nicoventures Trading Ltd Non-combustible aerosol delivery system
CN113735394A (zh) * 2021-09-18 2021-12-03 江苏省农业科学院 一种蓝藻泥氨基酸的制备方法及其产品和应用
WO2025226636A1 (en) * 2024-04-26 2025-10-30 Merck Sharp & Dohme Llc Engineered phenylalanine ammonia lyase polypeptides and methods of making and using the same

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US20170159038A1 (en) * 2014-04-16 2017-06-08 Codexis, Inc. Engineered tyrosine ammonia lyase

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Also Published As

Publication number Publication date
IL283894A (en) 2021-07-29
US11473077B2 (en) 2022-10-18
SG11202105668PA (en) 2021-06-29
US20230020928A1 (en) 2023-01-19
US20200190499A1 (en) 2020-06-18
EP3893860A1 (en) 2021-10-20
EP3893860A4 (en) 2023-03-29
WO2020123286A1 (en) 2020-06-18
US20230002752A1 (en) 2023-01-05
CA3122524A1 (en) 2020-06-18
AU2019397401A1 (en) 2021-06-17

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