AU2019397401A1 - Engineered tyrosine ammonia lyase - Google Patents

Engineered tyrosine ammonia lyase Download PDF

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Publication number
AU2019397401A1
AU2019397401A1 AU2019397401A AU2019397401A AU2019397401A1 AU 2019397401 A1 AU2019397401 A1 AU 2019397401A1 AU 2019397401 A AU2019397401 A AU 2019397401A AU 2019397401 A AU2019397401 A AU 2019397401A AU 2019397401 A1 AU2019397401 A1 AU 2019397401A1
Authority
AU
Australia
Prior art keywords
ammonia lyase
tyrosine ammonia
seq
recombinant
positions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2019397401A
Other languages
English (en)
Inventor
Nikki DELLAS
Stephan JENNE
Joyce Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Codexis Inc
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of AU2019397401A1 publication Critical patent/AU2019397401A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51Lyases (4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/225Tyrosine; 3,4-Dihydroxyphenylalanine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y403/00Carbon-nitrogen lyases (4.3)
    • C12Y403/01Ammonia-lyases (4.3.1)
    • C12Y403/01023Tyrosine ammonia-lyase (4.3.1.23)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2019397401A 2018-12-14 2019-12-06 Engineered tyrosine ammonia lyase Abandoned AU2019397401A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779647P 2018-12-14 2018-12-14
US62/779,647 2018-12-14
PCT/US2019/064891 WO2020123286A1 (en) 2018-12-14 2019-12-06 Engineered tyrosine ammonia lyase

Publications (1)

Publication Number Publication Date
AU2019397401A1 true AU2019397401A1 (en) 2021-06-17

Family

ID=71073423

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019397401A Abandoned AU2019397401A1 (en) 2018-12-14 2019-12-06 Engineered tyrosine ammonia lyase

Country Status (8)

Country Link
US (3) US11473077B2 (https=)
EP (1) EP3893860A4 (https=)
JP (1) JP2022513199A (https=)
AU (1) AU2019397401A1 (https=)
CA (1) CA3122524A1 (https=)
IL (1) IL283894A (https=)
SG (1) SG11202105668PA (https=)
WO (1) WO2020123286A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3122524A1 (en) * 2018-12-14 2020-06-18 Codexis, Inc. Engineered tyrosine ammonia lyase
GB202009251D0 (en) 2020-06-17 2020-07-29 Nicoventures Trading Ltd Non-combustible aerosol delivery system
CN113735394A (zh) * 2021-09-18 2021-12-03 江苏省农业科学院 一种蓝藻泥氨基酸的制备方法及其产品和应用
WO2025226636A1 (en) * 2024-04-26 2025-10-30 Merck Sharp & Dohme Llc Engineered phenylalanine ammonia lyase polypeptides and methods of making and using the same

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Also Published As

Publication number Publication date
JP2022513199A (ja) 2022-02-07
IL283894A (en) 2021-07-29
US11473077B2 (en) 2022-10-18
SG11202105668PA (en) 2021-06-29
US20230020928A1 (en) 2023-01-19
US20200190499A1 (en) 2020-06-18
EP3893860A1 (en) 2021-10-20
EP3893860A4 (en) 2023-03-29
WO2020123286A1 (en) 2020-06-18
US20230002752A1 (en) 2023-01-05
CA3122524A1 (en) 2020-06-18

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MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period